Investigation of role of vascular endothelial growth factor, Annexin A5 and Apelin by immunohistochemistry method in placenta of preeclampsia patients.

In this study, placentas were collected from 20 normotensive pregnant women as controls, 16 mild-preeclamptic pregnant women, and 16 severe preeclamptic women. VEGF, Annexin A5 and Apelin were examined in samples of placenta tissues by streptavidin-biotin-peroxidase complex immunohistochemical methods. Immunoreactivity scores (IRS) were obtained for each parameter.  VEGF and Apelin IRS were increased significantly in preeclamptic groups compared with control group (p <0.026, p<0.002 respectively). But Annexin A5 IRS was decreased significantly in preeclamptic groups compared with control group (p<0.04). In correlation with the intensity of disease, increase in VEGF and Apelin, and decrease in Annexin A5 supports roles of hemo-dynamic alterations in fetoplacental circulation and structural alterations in uteroplacental bed occurring in preeclampsia. PMID: 29208172 [PubMed - in process]
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Publication date: Available online 9 June 2018 Source:Pregnancy Hypertension Author(s): Genevieve Eastabrook, Tuba Aksoy, Samantha Bedell, Debbie Penava, Barbra de Vrijer Preeclampsia is a serious pregnancy condition defined as new-onset hypertension and proteinuria, commonly characterized as either early, ‘placental’, or late onset, ‘maternal’, using a cut-off of 34 weeks gestation. However, it may be more useful to differentiate between the vascular remodelling and placental invasion vs. inflammation and metabolic pathophysiology that underlie these forms of preeclampsia. Due to rising rates of o...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
AbstractPurpose of ReviewTo review the studies and practice guidelines on the preeclampsia risks in kidney donors and recipients.Recent FindingsThere is a small increased risk of gestational hypertension and preeclampsia in pregnancies that follow kidney donation. Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guideline (2017) and the 2015 American Society of Transplantation (AST) consensus conference statement recommends counseling kidney donors about this increased risk. There is no observed increase in fetal complications or eclampsia post-kidney donation. Preeclampsia is more commonly observed in ki...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
AbstractA 29-year-old woman with past medical history of hypertension was referred to our hospital for the evaluation of kidney dysfunction (serum creatinine 1.0  mg/dL), proteinuria (0.54 g/gCre), and microscopic hematuria. Renal biopsy before the first pregnancy was supportive for benign nephrosclerosis with no evidence of vasculitis. After her second pregnancy and delivery when she was 32 years old, she developed proteinuria of 3.2 g/gCre, hematuria, and elevated serum creatinine level of 2.6 mg/dL. Second renal biopsy revealed necrotizing glomerulonephritis and her serum MPO-ANCA was positive, ...
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 30 May 2018 Source:Pregnancy Hypertension Author(s): Pierre-Yves Robillard, Gustaaf Dekker, Gérard Chaouat, Philippe Le Bouteiller, Marco Scioscia, Thomas C. Hulsey The authors delineate seven quantum leap forward and, or revolutions having occurred during the 20th century in the understanding of the physiopathology of preeclampsia. First the discovery of the inflatable arm band permitting to measure blood pressure in 1896. Second, the discovery that eclamptic (convulsions), and later “pre”eclamptic (proteinuria) women presented hypertension in 1897 and confirmed in 19...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Conclusions Elevated expression of the plasma levels of sMerTK and sAxl, as well as the reduction of Gas6 were observed in severe PE patients. Furthermore, these changes were correlated with disease activity. TAM signaling might play a role in the pathogenesis of PE.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Conclusions The BPV indices correlated with subclinical echocardiographic changes and microalbuminuria in normotensive women with history of preeclampsia/eclampsia. The ARV of systolic BP for daytime could early predict such changes in those apparently healthy women.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Leticia B. Sene, Victor Hugo Goncalves Rizzi, Jose A. R. Gontijo, and Patricia A. Boer Studies have shown that adult offspring of mothers fed a protein-restricted diet during pregnancy present a pronounced reduction of nephron number associated with decreased fractional urinary sodium excretion and arterial hypertension. Additionally, recent advances in our understanding of the molecular pathways that govern the association of gestational nutritional restriction, intrauterine growth retardation and inflammation with impaired nephrogenesis, nephron underdosing and kidney fibrosis point to the epithelial to mesenchymal tran...
Source: Journal of Experimental Biology - Category: Biology Authors: Tags: RESEARCH ARTICLE Source Type: research
Abstract OBJECTIVES: To assess the agreement of home blood-pressure monitoring (HBPM) and office blood pressure measurements in a cohort of pregnant women with Hypertensive Disorders of Pregnancy (HDP). METHODS: This was a cohort study at St George's Hospital, University of London conducted between years 2016 and 2017. The inclusion criteria were chronic hypertension, gestational hypertension or high risk of developing preeclampsia, no significant proteinuria and no hematological or biochemical abnormalities. Each included patient was prescribed a personalized schedule of hospital visits and blood pressure me...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
Preeclampsia, an important cause of maternal mortality and morbidity worldwide, is defined as the new onset of hypertension in pregnancy after 20 weeks ’ gestation with associated proteinuria, maternal organ dysfunction or fetal growth restriction [1–3]. The incidence of preeclampsia is estimated to be between 3 and 10% of all pregnancies. While maternal death due to preeclampsia is less common in developed countries, maternal morbidity is high and is a major contributor to intensive care unit admissions—especially given that preeclampsia is more common with advanced maternal age, obesity and other medical co-morbidities.
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research
Preeclampsia has been shown to be associated with changes in cerebral structure and cognitive function later in life. Nf (neurofilaments) are specific scaffolding proteins of neurons, and their quantification in serum has been proposed as a biomarker for neuroaxonal injury. We performed a prospective, longitudinal, single-center study at the University Hospital of Basel to determine serum Nf concentrations in pregnant women with singleton pregnancies and with high risk of preeclampsia or with early signs of preeclampsia. Enrollment started at 21 weeks of gestation, followed up with multiple visits until delivery. Sixty out...
Source: Hypertension - Category: Cardiology Authors: Tags: Hypertension, Preeclampsia Original Articles Source Type: research
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