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Strong antimicrobial activity of Hypericum perforatum L. against oral isolates of Lactobacillus spp.

Strong antimicrobial activity of Hypericum perforatum L. against oral isolates of Lactobacillus spp. Cell Mol Biol (Noisy-le-grand). 2017 Nov 30;63(11):58-62 Authors: Khadem Nezhad S, Taghavi Zenouz A, Aghazadeh M, Samadi Kafil H Abstract Lactobacillus spp. are one of the first microorganisms involved in the development of dental caries in the first years of life of the child. The purpose of this study was to investigate the antibacterial effect of alcoholic extract of hypericin against strains of Lactobacillus spp. and determine its related MIC (minimum inhibitory concentration); and cytotoxic effect against gingival fibroblasts. Antimicrobial activity and MIC were evaluated using micro broth dilution method based on CLSI (clinical and laboratory standards institute) protocols. Determination of cytotoxicity was done by using MTT assay protocol on gingival fibroblast cells at 24, 48 and 72 hours after adding different concentrations of alcoholic extract of hypericin. Hypericin extract had an antimicrobial effect on lactobacillus spp., and its MIC was determined to be 0.625µg/ml . The IC50 value after 24, 48 and 72 hours was obtained as 0.89μg/ml, 0.7μg/ml and 0.604μg/ml, respectively. Hypericin extract MIC for L.acidophilus spp. was 0.625µg/ml and given that, MIC was less than IC50. This concentration does not have toxic effects on gingival fibroblast cells. The results of this study indicate that hypericin extract was able to elimina...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Background: Blood stream infections in patients with central venous catheters may arise from translocation of bacteria through a non-intact mucosa. These infections are known as mucosal barrier injury –laboratory confirmed blood stream infections (MBI-LCBI). Currently there are no proven strategies to prevent bacteremia secondary to mucosal barrier injury after hematopoietic stem cell transplant (HSCT). Xylitol is a non-fermentable sugar alcohol that reduces dental caries, plaque accumulation, and oral disease progression by inhibiting bacterial growth and reducing pathogenic community development.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
ConclusionsChildren in OOHC have high health needs. Comprehensive health assessments offer an opportunity to better identify and manage these needs. High hepatitis C exposure in utero was unexpected. This study highlights the need for comprehensive health screening assessments for all children in OOHC. OOHC clinic data can be helpful in planning broad interventions for children in OOHC.
Source: Journal of Paediatrics and Child Health - Category: Pediatrics Authors: Tags: Original Article Source Type: research
Conclusions: Hydroalcoholic extract ofH. leucocephalum have antibacterial effect onS.mutans at a concentration of 12.5mg/mL, indicating possible application of this extract in prevention of dental caries; however, future researches are necessary.
Source: Journal of Dental Biomaterials - Category: Dentistry Source Type: research
Discussion In the US during 2011, ~60,000 youth were incarcerated at some time in a correctional facility. Boys are detained more than girls (86% vs 14% respectively in the US, 95% male in the United Kingdom in 2014) but girls have more health issues. There are racial and ethnic differences with 38-40% of detainees being black, 23% being Hispanic/Latino and 32% being white, and 5% other. For detained youth, 5% are for violent crimes, 22% for non-violent property crimes and the majority of the rest are for non-violent offices such as substance use. The average length of detainment is 3-4 months and unfortunately the rates o...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Conclusions: In this study, higher prenatal fluoride exposure, in the general range of exposures reported for other general population samples of pregnant women and nonpregnant adults, was associated with lower scores on tests of cognitive function in the offspring at age 4 and 6–12 y. https://doi.org/10.1289/EHP655 Received: 14 June 2016 Revised: 08 May 2017 Accepted: 09 May 2017 Published: 19 September 2017 Please send correspondence to M. Bashash, Dalla Lana School of Public Health, 6th floor, 155 College St., Toronto, Ontario M5R3M7 Canada. Telephone: +1-416-978-6512. Email: m.bashash@utoronto.ca Supplement...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusion The study is intriguing because we already know that lithium affects how the brain and nervous system work through many different pathways. However, the results are difficult to interpret. The study seemed to suggest that lithium levels of more than 15 micrograms per litre could be protective against dementia in comparison with the lowest levels. However, that doesn't explain why levels of 5 to 10 micrograms per litre seemed to increase the risk of dementia in comparison with the lowest levels. It's possible that some other factors – linked to where people live but not necessarily...
Source: NHS News Feed - Category: Consumer Health News Tags: Neurology Source Type: news
To investigate the association between a series of behavioral and social-demographic factors, interleukin-1 beta (-3954 position, IL-1 β-CT), tumor necrosis factor-alpha (-308 position, TNF-α-GA single nucleotide promoter polymorphisms (SNPs) and DC experience in a sample of adolescents.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: RP - Research Poster Source Type: research
CONCLUSION: Knowledge with respect to oral health among engineering students of Bhubaneswar city is adequate regarding using fluoridated toothpaste and flosses. However, an unhealthy snacking habit, overusage of toothbrushes, consumption of alcohol, and practicing tobacco habit show the lack of oral health knowledge in these students. CLINICAL SIGNIFICANCE: Our study provides an idea about the present scenario in terms of oral hygiene and tobacco usage in young individuals. This can form the basis for oral health education and tobacco cessation program. Moreover, as the habit of tobacco usage starts early during colle...
Source: J Contemp Dent Pract - Category: Dentistry Authors: Tags: J Contemp Dent Pract Source Type: research
This study aimed to develop adhesive pastes containing calcium phosphate and α-mangostin for dental caries prevention using the optimization technique. Calcium phosphate was used as a remineralizing agent, and extracted α-mangostin was used as an antibacterial agent. The effect of the independent variables, which were fumed silica, Eudragit(®) EPO, polyethylene glycol, and ethyl alcohol, on the responses was investigated. The drying time, erosion rate, calcium release rate, and α-mangostin release rate were established as the measured responses. An equation and a model of the relationship were constru...
Source: AAPS PharmSciTech - Category: Drugs & Pharmacology Authors: Tags: AAPS PharmSciTech Source Type: research
The dentist may not be your favorite appointment, but it’s a necessity.  Good oral hygiene saves you from more than just tooth decay, cavities and bad breath. It is critically important because it can help prevent certain medical conditions such as cardiovascular disease and osteoporosis. And here’s something else: The state of your teeth, mouth and gums can clue your dentist into other medical issues you may need to address. By examining your mouth, your dentist can identify eating disorders, sleeping problems, anxiety, stress and more. Below are some of the things dentists can see about yo...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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