Endoplasmic reticulum stress induced Lox-1+ CD15+ polymorphonuclear myeloid-derived suppressor cells in hepatocellular carcinoma.

CONCLUSION: LOX-1+ CD15+ PMN-MDSC were elevated in HCC patients and suppressed T cell proliferation through ROS/Arg I pathway induced by ER stress. They presented positive association with the prognosis of HCC patients. This article is protected by copyright. All rights reserved.
PMID: 29211299 [PubMed - as supplied by publisher]

Source: Immunology - December 6, 2017 Category: Allergy & Immunology Authors: Jiang N, Xing YF, Hu B, Tang JX, Dong HM, He YM, Ruan DY, Ye QJ, Cai JR, Ma XK, Chen J, Cai XR, Lin ZX, Wu XY, Li X Tags: Immunology Source Type: research