CD271 Confers an Invasive and Metastatic Phenotype of Head and Neck Squamous Cell Carcinoma Through the Upregulation of Slug.
CONCLUSIONS: Activation of CD271 results in upregulation of Snai2/Slug, which, in turn, results in a more invasive phenotype and an enhanced capacity for metastasis to regional lymph nodes. These findings point to CD271 as a promising, therapeutic target for oral cancer metastasis.
PMID: 29208672 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Chung MK, Jung YH, Lee JK, Cho SY, Murillo-Sauca OJ, Uppaluri R, Shin JH, Sunwoo JB Tags: Clin Cancer Res Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Epithelial Cancer | Head and Neck Cancer | HNSCC | Oral Cancer | Skin Cancer | Squamous Cell Carcinoma | Study