Lessons Learned from Bone Marrow Failure in Systemic Lupus Erythematosus: Case Reports and Review of the Literature

Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease with variable multisystem involvement. Hematologic abnormalities involving multiple cell lineages are common in SLE. Lymphopenia was present in 75% among a large cohort of SLE patients and occurred more frequently than any other criterion used to classify the disease [1]. Anemia is estimated to occur in about 50% of patients [2]. While anemia of chronic disease and iron deficiency are quite common, autoantibody- or complement-mediated autoimmune hemolytic anemia are occasionally encountered [3].
Source: Seminars in Arthritis and Rheumatism - Category: Rheumatology Authors: Source Type: research