Understanding the role of environmental factors in the development of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists for increased risk of SLE associated with exposure to crystalline silica, current cigarette smoking, use of oral contraceptives, and postmenopausal hormone replacement therapy, while there is an inverse association with alcohol use.

Source: Best Practice and Research. Clinical Rheumatology - June 1, 2017 Category: Rheumatology Authors: Christine G. Parks, Aline de Souza Espindola Santos, Medha Barbhaiya, Karen H. Costenbader Tags: 2 Source Type: research