Evaluation of lipid-lowering effect of Cynara scolymus extract-loaded mesoporous silica nanoparticles on ultra-lipid-fed mice

AbstractIn current investigation, twenty mice were divided into 4 different equal groups as follows: group CS which received 0.1  mlCynara scolymus extract (diluted in distilled water) at dose of 600  mg kg−1 daily for 3  weeks, group A which received 0.1 ml Atorvastatin 40 (diluted in distilled water) at dose of 20 mg kg−1 daily for 21  days, group T which received 0.1 ml ofCynara scolymus extract at dose of 600  mg kg−1 daily in nonporous (diluted in distilled water) during experimental period, and control group (group C) which received the same volume of normal saline. The supplements were gavaged in all animals, during experiment period, and blood samples were obtained after 21  days. Results showed that total cholesterol and triglyceride decreased significantly in the treatment group compared with the control and CS groups (p <  0.05). It seems that mesoporous silica nanoparticles improve drug delivery and thereforeCynara scolymus extract-loaded mesoporous silica nanoparticles has more effective lipid-lowering action thanCynara scolymus extract.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research