The wrong women are getting screened for breast cancer

Women at low risk for breast cancer are getting extra screening while the ones that need it most aren't being screened enough, according to a new University of New Mexico study.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 17 November 2018Source: Pathology - Research and PracticeAuthor(s): Li MaAbstractNeoadjuvant chemotherapy(NCT) has become the standard treatment for breast cancer. The information about the tumor’s sensitivity to chemotherapy and prognostic significance based on response to therapy can be provided after individualized neoadjuvant treatment. The biomarkers are key factors in the decision-making process regarding treatment as well as important prognostic indicators. Studies have shown that patients who achieve pathological complete response(pCR) after NCT have a better prognosis. For ...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 17 November 2018Source: International Journal of PharmaceuticsAuthor(s): Nicolò Mauro, Cinzia Scialabba, Roberto Puleio, Paola Varvarà, Mariano Licciardi, Gennara Cavallaro, Gaetano GiammonaAbstractThe extremely complex tumor microenvironment (TME) in humans is the major responsible for the therapeutic failure in cancer nanomedicine. A new concept of disease-driven nanomedicine, henceforth named “Theranomics”, which attempts to target cancer cells and TME on the whole, represents an attractive alternative. Herein, a nanomedicine able to co-deliver doxorubicin and...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 November 2018Source: Seminars in Cell &Developmental BiologyAuthor(s): Choon Leng So, Jodi M. Saunus, Sarah J. Roberts-Thomson, Gregory R. MonteithAbstractThe past two decades have seen the identification of important roles for calcium signalling in many of the hallmarks of cancer. One of the cancer types that has been a particular focus of such studies is breast cancer. The breast is intrinsically linked to the calcium ion due to the importance of milk calcium in neonatal growth and development. Indeed, some of the calcium channels and pumps involved in transporting calcium ions i...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
Authors: Abstract The interaction between pituitary hormones, GH - PRL, and Growth Factors, GF, plays a fundamental role in the physiological and neoplastic mechanisms of growth, the latter using these factors to a much greater extent compared to the former, with a direct dose-dependent effect on the speed of local or metastatic expansion. In hormone-dependent tumours, the respective male and female sex hormones interact with GH - PRL - GF to sustain the expansion of the tumour. We carried out a review of the literature on the relationship between the expression of GH and GHR in tumour tissues compared to healthy ...
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
In conclusion, the polymorphisms of TP53 at codon 72 and WRAP53 at codon 68 and their haplotype may confer an increased risk of breast cancer in the assessed population.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
CONCLUSION Once established, stage III MRONJ can be challenging to manage for both the dental team and for the patient. This case demonstrates the importance of a comprehensive dental examination and need for preventative dental treatment prior to starting anti-resorptive therapy in order to prevent such instances. PMID: 30428967 [PubMed - in process]
Source: Primary dental care : journal of the Faculty of General Dental Practitioners UK - Category: Dentistry Tags: Prim Dent J Source Type: research
Publication date: Available online 15 November 2018Source: International Journal of PharmaceuticsAuthor(s): Wenxing Song, David A. Gregory, Haider Al-janabi, Munitta Muthana, Zhiqiang Cai, Xiubo ZhaoAbstractThe lack of efficient and cost-effective methods for gene delivery has significantly hindered the applications of gene therapy. In this paper, a simple one step and cost effective salting-out method has been explored to fabricate silk-PEI nanoparticles (SPPs) and magnetic-silk/PEI core-shell nanoparticles (MSPPs) for targeted delivery of c-myc antisense oligodeoxynucleotides (ODNs) into MDA-MB-231 breast cancer cells. T...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Authors: Fekih-Romdhane F, Henchiri H, Ridha R, Labbane R, Cheour M Abstract Breast cancer is a chronic disease that affects both patients and their caregivers. Spouses, in particular, will generally assume the role of primary caregiver and experience significant physical, social, economic and emotional stress. In the face of cancer, being the spouse of a patient is synonymous with unmet psychosocial needs and a new role assignment, that of a primary caregiver. In addition, cancer confronts spouses with fear of partner loss. This leads to a set of adverse consequences such as depression, anxiety, uncertainty, stres...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
ConclusionInfodemiology provides preliminary information that could help in generating hypotheses, assessing health-care interventions, or even in providing patient-centered care.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractThe impact of diet and associated lifestyle choices on the risk of developing cancer is well established. However, whether these parameters also affect cancer recurrence and survival is less well investigated. Virtually nothing is known about the impact of diet on the development of metastases. It is therefore significant that a study in this issue of Clinical and experimental metastasis reports that breast cancer-bearing mice fed on a diet rich in long-chain omega-3 fatty acids had a lower incidence of metastasis than control mice, which was associated with modified infiltration of immune cells into the tumors. Th...
Source: Clinical and Experimental Metastasis - Category: Cancer & Oncology Source Type: research
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