Surge in gun sales after Sandy Hook led to spike in accidental gun deaths, study says

In the days after the horrific shooting at Sandy Hook Elementary School, gun enthusiasts rushed to buy millions of firearms, driven by fears that the massacre would spark new gun legislation. Those restrictions never became a reality, but a new study concludes that all the additional guns caused a significant jump in accidental firearm deaths. […]Related:A mother got the flu from her children — and was dead two days laterGene therapy makes a big advance treating hemophilia B blood disorderThe moral differences between pro- and anti-vaccine parents
Source: Washington Post: To Your Health - Category: Consumer Health News Source Type: news

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atrics. Abstract JUSTIFICATION: Despite having standard principles of management of hemophilia, treatment differs in various countries depending on available resources. Guideline for management of hemophilia in Indian setting is essential. PROCESS: Indian Academy of Pediatrics conducted a consultative meeting on Hemophilia on 18th September, 2016 in New Delhi, which was attended by experts in the field working across India. Scientific literature was reviewed, and guidelines were drafted. All expert committee members reviewed the final manuscript. OBJECTIVE: To bring out consensus guidelines in diagnosis ...
Source: Indian Pediatrics - Category: Pediatrics Authors: Tags: Indian Pediatr Source Type: research
Abstract The development of inhibitory antibodies to factor VIII is the most serious complication of replacement therapy in hemophilia A. Activation of the innate immune system during exposure to this protein contributes to inhibitor development. However, avoidance of factor VIII exposure during innate immune system activation by external stimuli (e.g. vaccines) has not been consistently shown to prevent inhibitors. We hypothesized that dexamethasone, a drug with potent anti-inflammatory effects, could prevent inhibitors by promoting immunologic tolerance to factor VIII in hemophilia A mice. Transient dexamethason...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
Haemophilia, EarlyView.
Source: Haemophilia - Category: Hematology Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blogJust when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 217: children who changed medicine. Question 1In 1796, What did James Phipps (1788-1853) participate in that significantly changed the course of modern medicine?+ Reveal the Funtabulous Answerexpand(document.getElementById('ddet87874616'));expand(docume...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Frivolous Friday Five Christmas disease cow pox Doogie Howser Edward Jenner Haemophilia B IVF James Phipps Lorenzo's oil. Lorenzo Odone Louise Joy Brown small pox stephen christmas test tube baby Source Type: blogs
The children were the first to get sick. They spent Thanksgiving with sore throats and chills and fevers. By the end of the long weekend, the adults who had gathered for the family’s holiday meal in Phoenix were feeling flu symptoms, too. “We were all together for Thanksgiving, and the little kids got sick, then […]Related:Gene therapy makes a big advance treating hemophilia B blood disorderAn Illinois doctor traded drugs for sex and cash. He just pleaded guilty.The moral differences between pro- and anti-vaccine parents
Source: Washington Post: To Your Health - Category: Consumer Health News Source Type: news
Jay Konduros used to rush home several times a year after accidentally cutting or bumping himself. There he would inject himself with refrigerated blood-clotting factor to prevent internal bleeding and extensive bruising and swelling. “I was walking on eggshells all the time,” said the former aerospace engineer who has a blood disorder called hemophilia B. Then, […]Related:The moral differences between pro- and anti-vaccine parents‘The Woebot will see you now’ — the rise of chatbot therapyA woman with a transplanted uterus just gave birth — a first for the U.S.
Source: Washington Post: To Your Health - Category: Consumer Health News Source Type: news
BackgroundInhibitor development in previously untreated patients (PUPs) with severe haemophilia A is a multifactorial event. It is unknown whether paediatric vaccinations given in close proximity to factor VIII (FVIII) are associated with inhibitor development. ObjectiveTo assess whether paediatric vaccinations in close proximity to FVIII within the first 75 exposure days (EDs) are associated with inhibitor development in PUPs with severe haemophilia A. MethodsWe included 375 PUPs with severe haemophilia A (
Source: Haemophilia - Category: Hematology Authors: Tags: ORIGINAL ARTICLE Source Type: research
IntroductionSubcutaneous (SQ) vaccination has emerged as standard of care in children with severe bleeding disorders to reduce unnecessary factor exposure and avoid provoking an intramuscular bleed, but little is known about comparative immunogenicity to intramuscular (IM) vaccination. AimTo confirm immunogenicity of Diphtheria Tetanus acellular Pertussis (DTaP) vaccines administered SQ to individuals
Source: Haemophilia - Category: Hematology Authors: Tags: ORIGINAL ARTICLE Source Type: research
High viscosity biologic drugs generally require syringe injections, but many patients are extremely uncomfortable around long needles and injection times can create a great deal of anxiety. Portal Instruments, a company out of Cambridge, Massachusett...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Pediatrics Source Type: blogs
Abstract Plastid-made biopharmaceuticals treat major metabolic or genetic disorders, including Alzheimer's, diabetes, hypertension, hemophilia, and retinopathy. Booster vaccines made in chloroplasts prevent global infectious diseases, such as tuberculosis, malaria, cholera, and polio, and biological threats, such as anthrax and plague. Recent advances in this field include commercial-scale production of human therapeutic proteins in FDA-approved cGMP facilities, development of tags to deliver protein drugs to targeted human cells or tissues, methods to deliver precise doses, and long-term stability of protein drug...
Source: Annual Review of Genetics - Category: Genetics & Stem Cells Authors: Tags: Annu Rev Genet Source Type: research
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