A better mammogram? Study puts 3-D scans to the test
Health officials are starting a huge study to tell if the newer, sometimes pricier scans really improve screening for breast cancer
Researchers have developed a quicker, better and cheaper way than mammograms to detect breast cancer: a laser scanner that can find tumors in 15 seconds.
(California Institute of Technology) Lihong Wang, Caltech's Bren Professor of Medical Engineering and Electrical Engineering, has developed a laser-sonic scanning system that can identify breast tumors quickly and safely.
This study was designed to assess a novel gastrin releasing peptide receptor (GRPR) and integrin αvβ3 dual targeting PET/CT using 68Ga-BBN-RGD in patients with breast cancer and metastasis, and to evaluate the correlation between imaging quantification and immunohistochemical result of GRPR and integrin αvβ3 expression within primary and metastatic breast cancer lesions. Methods: A macrocyclic chelator, 1,4,7-triazacyclononane-N,N’,N"-triacetic acid (NOTA) conjugated BBN-RGD was synthesized and labeled with 68Ga. With ethics committee approval and written informed consent, 22 patients (F, a...
Conclusions: WB PET SUV's and PEM SUV's were highly correlated, and both were correlated to Ki-67 and histological grade. Additional lesions were detected in PEM scans in a significant number of patients compared to WB PET, while another significant proportion of patients had lesions not visualized only in PEM due to positioning.
Conclusions: This pilot study indicated that the uptake of gastrin-releasing peptide receptor antagonist 68Ga-NOTA-RM26 may correlate with ER expression in breast cancer. To avoid the physiological uptake of 68Ga-NOTA-RM26 in normal breast tissue, it is suggested that this examination not be performed during the secretory phase of the menstrual cycle. Figure legend: Figure 1. A 60-year-old patient with breast invasive ductal carcinoma showed intense 68Ga-RM26 uptake in the primary tumor (blue arrows) and lymph node metastasis (yellow arrows) on the left side. The tumor stained positively for ER (F) and GRPR (G); the lymph ...
Abstract Positron emission mammography (PEM) has higher detection sensitivity for breast cancer compared with whole-body positron emission tomography (PET) due to higher spatial resolution. We have developed a new PEM device with high resolution over a wide field of view. This PEM device comprises novel scintillation crystals, praseodymium-doped lutetium aluminum garnet (Pr:LuAG). In the present study, the clinical use of the newly developed PEM for the detection of small breast cancer was compared with that of the conventional PET-computed tomography (PET/CT). Eighty-two patients with breast cancer less than 20 m...
Women who missed out on mammograms due to a computer error should ignore invitations for a ‘catch-up’ scan, according to an architect of the NHS breast cancer screening programme.
Conclusion: The results from this NMA indicate that the diagnostic value of the BSGI, MG + SMM, MRI and CE-MRI methods for BC were relatively higher in terms of sensitivity, specificity and accuracy.Cell Physiol Biochem 2018;46:2041 –2055
Conclusion: In colonic metastases, tumor markers might not be totally reliable. In asymptomatic cases, clinical conditions might be underappreciated, missing local or distant recurrence. CT and PET/CT scan might be useful in diagnosing small volume diseases, and steering endoscopist toward GI metastasis originating from the breast. CESM represents a tolerable and feasible tool that rules out multicentricity and multifocality of breast localization. Moreover, particular patients could tolerate it better than magnetic resonance imaging (MRI).
The goals of this article are to discuss the role of breast-specific PET imaging of women with breast cancer, compare the clinical performance of positron emission mammography (PEM) and MR imaging for current indications, and provide recommendations for when women should undergo PEM instead of breast MR imaging.