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Dealing With Diabetes in Disaster Zones: Planning Is Vital Dealing With Diabetes in Disaster Zones: Planning Is Vital

How to help people living with diabetes caught up in natural or human-caused disasters was a central focus of the IDF Congress this year; there is much work still to be done, attendees heard.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

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Authors: Manduchi E, Chesi A, Hall MA, Grant SFA, Moore JH Abstract We utilized evidence for enhancer-promoter interactions from functional genomics data in order to build biological filters to narrow down the search space for two-way Single Nucleotide Polymorphism (SNP) interactions in Type 2 Diabetes (T2D) Genome Wide Association Studies (GWAS). This has led us to the identification of a reproducible statistically significant SNP pair associated with T2D. As more functional genomics data are being generated that can help identify potentially interacting enhancer-promoter pairs in larger collection of tissues/cell...
Source: Pacific Symposium on Biocomputing - Category: Bioinformatics Tags: Pac Symp Biocomput Source Type: research
Authors: Lussier YA, Berghout J, Vitali F, Ramos KS, Kann M, Moore JH Abstract Noncoding DNA - once called "junk" has revealed itself to be full of function. Technology development has allowed researchers to gather genome-scale data pointing towards complex regulatory regions, expression and function of noncoding RNA genes, and conserved elements. Variation in these regions has been tied to variation in biological function and human disease. This PSB session tackles the problem of handling, analyzing and interpreting the data relating to variation in and interactions between noncoding regions through comp...
Source: Pacific Symposium on Biocomputing - Category: Bioinformatics Tags: Pac Symp Biocomput Source Type: research
Authors: Bashoff EC, Beaser RS Abstract Preview When diabetic patients learn that insulin therapy is necessary, they may fee) overwhelmed by anticipated changes in lifestyle. The key to success is to realize that every person with diabetes has individual needs and that these must be assessed, addressed, and accommodated. Better diabetes control will be the result. PMID: 29219711 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
This article tells you what to look for in examining the feet, how to advise patients in foot care, and what to do if ulcers occur despite preventive efforts. PMID: 29219704 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Authors: Clark DW, Nowak TV Abstract Preview As many as 30% of patients with long-standing diabetes mellitus may have symptoms of gastroparesis, and others are found to have the condition despite being asymptomatic. When should diabetic gastroparesis be suspected, and which are the best tests for detecting it? What factors can exacerbate it? Drs Clark and Nowak address these questions and discuss the therapeutic value of dietary modification, pro- kinetic agents, and surgical intervention. PMID: 29219646 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Authors: Zou F, Lai X, Li J, Lei S, Hu L Abstract Type 1 diabetes mellitus (T1DM) is an autoimmune disease due to progressive injury of islet cells mediated by T lymphocytes (T cells). Our previous studies have shown that only cathepsin G (CatG), not other proteases, is involved in the antigen presentation of proinsulin, and if the presentation is inhibited, the activation of CD4+ T cells induced by proinsulin is alleviated in T1DM patients, and CatG-specific inhibitor reduces the activation of CD4+ cells induced by proinsulin in T1DM patients. Therefore, we hypothesize that CatG may play an important role in the a...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
This study evaluated the effects of AS-IV on high glucose induced-gastric mucosal lesions compared to the effects of the Bu-zhong-yi-qi pill and the Xiaoke pill, which are already in clinical use. STZ-induced diabetic SD rats were treated with drugs for 12 weeks. Diabetes serum (DS) was used to mimic high glucose conditions in GES-1 cells in vitro at different concentrations and time points. The drugs were set at three concentration gradients for 24, 48 and 72 h before being added to DS-induced GES-1 cells. The proliferation activity and inhibition ratio of cells were measured by the CCK-8 assay. Gastric tissues were exami...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
In this study, we used the Clinical Practice Research Datalink (CPRD) to estimate clinically measured SBP and DBP trajectories for 20 years prior to death, for individuals dying at 60 years and older. Second, we compared the linear SBP trends for years 10 to 3 years before death in patients who died and age- and sex-matched controls who survived at least 9 years. These approaches aimed to separate age from end-of-life associations, and avoid healthy survivor biases. Twenty years before death, estimated mean SBPs increased with increasing age at death (60-69 years, 139.5 mm Hg; ≥90 years, 150.0 mm Hg). All age-at-...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Piga A Abstract Conventional treatment of thalassemia, namely regular blood transfusion and iron chelation, improves perspectives and quality of life; however, successful treatment leads to more time in which long-term complications such as bone disease can develop. Thalassemia bone disease (TBD) is unique: all aspects, from bone anatomy and bone quality to mineral density, may be affected, with important morbidity including osteoporosis, fractures, spinal deformities, nerve compression, and pain. Clinical presentations include growth impairment, rickets-like features, back pain, spinal deformities, any si...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
CONCLUSIONS: Our results show that TFA could dose-dependently ameliorate renal inflammation by inhibiting the activation of iRhom2/TACE signalling and attenuating ER stress. These results suggest that TFA has potential therapeutic value for the treatment of DN in humans. PMID: 29221422 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
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