Surge in gun sales after Sandy Hook shooting led to spike in accidental gun deaths, study says

In the days after the horrific shooting at Sandy Hook Elementary School, gun enthusiasts rushed to buy millions of firearms, driven by fears that the massacre would spark new gun legislation. Those restrictions never became a reality, but a new study concludes that all the additional guns caused a significant jump in accidental firearm deaths. […]Related:A mother got the flu from her children — and was dead two days laterGene therapy makes a big advance treating hemophilia B blood disorderAn Illinois doctor traded drugs for sex and cash. He just pleaded guilty.
Source: Washington Post: To Your Health - Category: Consumer Health News Source Type: news

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The primary objective was to assess the effect of ABO blood group on von Willebrand factor (VWF) rise induced by four bouts of moderate-intensity physical activity, on pharmacokinetics of a B-domain-deleted recombinant FVIII (BDD-rFVIII), and haemostatic parameters in severe haemophilia A patients with a null mutation. The secondary objective was to compare the response to exercise according to infused product type in a subgroup of patients who previously participated to the same exercise protocol, while treated with a full length recombinant FVIII (FL-rFVIII). Twenty patients had two visits (rest and exercise). Blood samp...
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research
We present a case that highlights the difficulties of recognizing this diagnosis, the role of genetic testing, and the identification of a 2N variant that has not been previously described.
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: CASE REPORTS Source Type: research
American Journal of Hematology,Volume 0, Issue ja, -Not available-.
Source: American Journal of Hematology - Category: Hematology Authors: Source Type: research
Haemophilia, EarlyView.
Source: Haemophilia - Category: Hematology Authors: Source Type: research
CONCLUSIONS: The combination of FVIIa and FX improved TG more efficiently than rFVIIa alone or plasma in dilutional coagulopathy models. The required FVIIa dose in FVIIa/FX was considerably lower than those reported during bypassing therapy in hemophilia patients (1.4-2.8 μg/mL). The combination of plasma could restore coagulation more efficiently compared to FVIIa/FX alone. Lesser FVIIa requirement to exert procoagulant activity may be favorable in terms of reducing systemic thromboembolic complications. PMID: 30320649 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Joint bleeds are common in congenital hemophilia but rare in acquired hemophilia A (aHA) for reasons unknown. To identify key mechanisms responsible for joint-specific bleeding in congenital hemophilia, bleeding phenotypes after joint injury and tail transection were compared in aHA wild-type (WT) mice (receiving an anti–factor VIII [FVIII] antibody) and congenital HA (FVIII–/–) mice. Both aHA and FVIII–/– mice bled severely after tail transection, but consistent with clinical findings, joint bleeding was notably milder in aHA compared with FVIII–/– mice. Focus was directed to thro...
Source: Blood - Category: Hematology Authors: Tags: Thrombosis and Hemostasis, Vascular Biology Source Type: research
Journal of Thrombosis and Haemostasis,Volume 0, Issue ja, -Not available-.
Source: Journal of Thrombosis and Haemostasis - Category: Hematology Authors: Source Type: research
Condition:   Acquired Hemophilia A Interventions:   Drug: Bortezomib;   Drug: Rituximab Sponsor:   Peking Union Medical College Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
h W Abstract The life expectancy of patients with haemophilia has increased and therefore the interest in age-related comorbidities has grown. The aim of this study was to determine whether haemophilia patients have a different endothelial function compared with the general population. A total of 26 patients with severe or moderate haemophilia A or B, 14 controls and 36 patients with coronary artery disease (CAD) were included in this study. Five markers of endothelial dysfunction (MOEDs) were determined. Moreover, the endothelial function was examined using the Itamar Endo-PAT, and the reactive hyperemia index (R...
Source: Hamostaseologie - Category: Hematology Authors: Tags: Hamostaseologie Source Type: research
Haemophilia, EarlyView.
Source: Haemophilia - Category: Hematology Authors: Source Type: research
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