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Surge in gun sales after Sandy Hook shooting led to spike in accidental gun deaths, study says

In the days after the horrific shooting at Sandy Hook Elementary School, gun enthusiasts rushed to buy millions of firearms, driven by fears that the massacre would spark new gun legislation. Those restrictions never became a reality, but a new study concludes that all the additional guns caused a significant jump in accidental firearm deaths. […]Related:A mother got the flu from her children — and was dead two days laterGene therapy makes a big advance treating hemophilia B blood disorderAn Illinois doctor traded drugs for sex and cash. He just pleaded guilty.
Source: Washington Post: To Your Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 23 February 2018 Source:Blood Cells, Molecules, and Diseases Author(s): Hilda Luna-Záizar, José Ángel González-Alcázar, Natalia Evangelista-Castro, Lilia Beatriz Aguilar-López, Sandra Luz Ruiz-Quezada, Claudia Patricia Beltrán-Miranda, Ana Rebeca Jaloma-Cruz Intron-22 (Inv22) and intron-1 (Inv1) inversions account for approximately one half of all severe cases of hemophilia A (SHA) worldwide. Inhibitor development against exogenous factor VIII (FVIII) represents a major complication in HA. The causative F8 mutation is considered the most d...
Source: Blood Cells, Molecules, and Diseases - Category: Hematology Source Type: research
Acquired Hemophilia A (AHA) is rare bleeding disorder caused by inhibitors (auto-antibodies) to factor VIIIA. (1,2) It is associated with severe bleeding. AHA clinical presentation is different from the inherited hemophilia that leads to misdiagnosis.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Tags: Case Report Source Type: research
(National Institute of Standards and Technology (NIST)) LinkedIn: Chinese Hamster Ovary cells, known as CHO, play an important role in modern medicine. NIST's new CHO peptide library will enable better production of treatments for psoriasis, cancer, hemophilia and leukemia.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
American Journal of Roentgenology, Ahead of Print.
Source: American Journal of Roentgenology - Category: Radiology Authors: Source Type: research
Abstract Emicizumab is a recombinant, humanized, bispecific, monoclonal antibody that bridges activated factor IX and factor X to restore the function of deficient factor VIII. Treatment of bleeding in patients with hemophilia and inhibitors involves the use of bypassing agents (BPA).These molecules are also used for the management of breakthrough bleeds in patients on prophylaxis with emicizumab, with increased concerns about the risks of combining two procoagulant drugs. Using thrombin generation assay, we tailored the dosage of activated prothrombin complex concentrate (APCC) and successfully treated an acute s...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
Source: British Journal of Haematology - Category: Hematology Authors: Tags: Correspondence Source Type: research
Acquired Hemophilia A (AHA) is a rare disease that requires urgent management. Currently, there is no consensus regarding optimal management in aged people. This systematic review aimed to describe diagnosis, clinical features, management, and endpoints in population aged 65 years or over with AHA.A literature search up to and including 31st May 2017 was performed in Medline, Embase, and Scopus. The search strategy on article titles comprised the following terms: “acquired” AND (“hemophilia A” OR “haemophilia A”).
Source: Seminars in Hematology - Category: Hematology Authors: Source Type: research
Publication date: Available online 19 February 2018 Source:The Journal of Foot and Ankle Surgery Author(s): Necip Selcuk Yontar, Ata Can, Tahir Ögüt Hemophilia is a disorder of blood coagulation with X-linked recessive inheritance. It is characterized by uncontrollable hemorrhage, and 80% of these occur intraarticularly. With recurrent hemarthrosis, recurrent synovitis occurs, which eventually leads to the formation of articular contractures. The key to the prevention of hemophilic joint complications is successful prevention of bleeding and management of the initial hemarthrosis. However, after the development ...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
rc;t RAA Abstract BACKGROUND:  Nonsevere haemophilia A (HA) patients can be treated with desmopressin. Response of factor VIII activity (FVIII:C) differs between patients and is difficult to predict. OBJECTIVES:  Our aims were to describe FVIII:C response after desmopressin and its reproducibility by population pharmacokinetic (PK) modelling. PATIENTS AND METHODS:  Retrospective data of 128 nonsevere HA patients (age 7-75 years) receiving an intravenous or intranasal dose of desmopressin were used. PK modelling of FVIII:C was performed by nonlinear mixed effect modelling. Reproducibility o...
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: Letters Source Type: research
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