Surge in gun sales after Sandy Hook shooting led to spike in accidental gun deaths, study says

In the days after the horrific shooting at Sandy Hook Elementary School, gun enthusiasts rushed to buy millions of firearms, driven by fears that the massacre would spark new gun legislation. Those restrictions never became a reality, but a new study concludes that all the additional guns caused a significant jump in accidental firearm deaths. […]Related:A mother got the flu from her children — and was dead two days laterGene therapy makes a big advance treating hemophilia B blood disorderAn Illinois doctor traded drugs for sex and cash. He just pleaded guilty.
Source: Washington Post: To Your Health - Category: Consumer Health News Source Type: news

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This study aims at the detection of subclinical knee-joint involvement by USG, in patients with moderate to severe Haemophilia. 27 patients suffering from moderate and severe Haemophilia and 27 age-matched controls were studied. USG of bilateral knee joints was done to analyse cartilage and synovial thickness, synovial vascularity and resistive index of vascular flow along with synovial collection. The relevant clinical parameters (age at diagnosis and study enrolment, severity of haemophilia A, annualized bleeding rates, total number of joint bleeds, spontaneous and provoked bleed, number of episodes treated with factor V...
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
CONCLUSIONS: Single doses of PF-06741086 at multiple dose levels were safe and well tolerated in a healthy adult male population. The safety, PK and PD data from this study support progression to a multiple dose study in hemophilia patients. This article is protected by copyright. All rights reserved. PMID: 29908043 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research
Hemophilia is an inherited bleeding disorder. With proper treatment and self-care, persons with hemophilia can maintain an active, productive lifestyle. Hemophilia can be mild, moderate, or severe, depending on the degree of plasma clotting factor deficiency. The aim of the study was to assess the utility of ISTH-BAT in diagnosis, determining severity of the bleeding condition in newly diagnosed and known hemophilia patients, compare the bleeding score (BS) in adult and pediatric groups and investigate its association with plasma factor levels.
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Source Type: research
Hemophilia is an inherited bleeding disorder. With proper treatment and self-care, persons with hemophilia can maintain an active, productive lifestyle. Hemophilia can be mild, moderate, or severe, depending on the degree of plasma clotting factor deficiency.The aim of the study was to assess the utility of ISTH-BAT in diagnosis, determining severity of the bleeding condition in newly diagnosed and known hemophilia patients, compare the bleeding score (BS) in adult and pediatric groups and investigate its association with plasma factor levels.
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Source Type: research
Authors: Castaman G, Linari S Abstract INTRODUCTION: Early long-term prophylaxis is the standard of care to prevent joint bleeding and chronic arthropathy in patients with severe hemophilia. Areas covered: Despite the obvious prophylaxis advantages upon the clinical outcomes, there are still several drawbacks to be addressed for the optimal patients' compliance. Frequency of treatment due to short half-life of conventional FVIII and FIX concentrates, difficult venous access, adherence to the prescribed therapy and costs may represent significant critical issues. The development of inhibitors also makes replacement ...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Conclusion The results from this survey of 31 centers with established programs demonstrates the HTCs ’ reliance on 340B program support for vital comprehensive services, that are otherwise non-reimbursable, and highlights the importance of the 340B program in sustaining the high quality of care and in increasing access for a geographically dispersed, medically vulnerable population.
Source: Maternal and Child Health Journal - Category: Health Management Source Type: research
CONCLUSION: The results of our study detail the N-glycan repertoire of pdFVIII to an unprecedented level, and for the first time, provide evidence of N-glycolylneuraminic acid (NeuGc) found on pdFVIII. Although site-specific glycosylation of rFVIII proved consistent with pdFVIII regardless of expression system, the entire N-glycan content of each sample appeared significantly different. While the proportion of biologically important epitopes common to all samples (i.e. sialylation and high-mannose) varied between samples, some recombinant products expressed distinct and immunologically relevant epitopes such as LacdiNAc (L...
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research
CONCLUSIONS: SIA (600 nM) or aPCC (0.5 U/mL) alone resulted in peak thrombin concentrations (Cmax ) of 21.4 and 38.6 nM, respectively, both lower than normal (83.7 ± 29.8 nM). SIA plus aPCC (0.5 U/mL) increased Cmax 17-fold over SIA alone, exceeding reference plasma by 4.2-fold. This hypercoagulable effect occurred with 600 nM SIA combined with as little as 0.25 U/mL aPCC, confirmed by ROTEM. FIX was the main driver for enhanced TG. SIA plus rFVIIa (1.75 μg/mL) induced a 1.8-fold increase in thrombin Cmax in platelet-rich plasma, but did not reach normal range. These in vitro experiments demonstrate excessiv...
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research
Mechanisms of action of monoclonal antibodies against tissue factor pathway inhibitor (TFPI).
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Authors: Brodin E, Hadzibajramovic E, Baghaei F, Sunnerhagen KS, Lundgren-Nilsson Å Abstract OBJECTIVES: To describe self-reported activity using the Haemophilia Activity List (HAL) for Swedish adults with haemophilia and to detect any changes over time. METHOD: The HAL was sent to the adult population with haemophilia A and B, moderate and severe form, living in Sweden (n = 260). Participants completed the HAL and a questionnaire on sociodemographic and medical information. From a previous study cohort, 61 persons had responded twice to the HAL. The investigated group was divided into early...
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
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