Increase in accidental deaths follows spike in gun sales, study finds

After 26 children and educators were gunned down at Sandy Hook Elementary School in 2012 and President Barack Obama talked about increasing gun control, Americans bought more guns. But instead of offering protection, at least in some cases, the sales increased the chances that people would be accidentally shot and killed, according to a study published Thursday in Science magazine.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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Jing-hua Peng, Jing Leng, Hua-jie Tian, Tao Yang, Yi Fang, Qin Feng, Yu Zhao, Yi-yang Hu
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: March 2019Source: Biomedicine &Pharmacotherapy, Volume 111Author(s): Jinzhou Zhu, Jiannan Huang, Daopeng Dai, Xia Wang, Jing Gao, Wei Han, Ruiyan ZhangAbstractThe interleukin-1 (IL-1) signaling pathway plays a vital role in multiple mechanisms associated with myocardial ischemia–reperfusion (I/R) injury, including inflammation and apoptosis. An IL-1 receptor antagonist (IL-1Ra) can block IL-1 by competitive binding to the IL-1 receptor type I (IL-1RI) and thus may provide a cardioprotective effect. In the present investigation, we determined whether exogenous administration of recombinant human ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: February 2019Source: Biomedicine &Pharmacotherapy, Volume 110Author(s): Jianyang Wang, Hong Zhao, Jing Yu, Xin Xu, Wenyang Liu, Hao Jing, Ning Li, Yuan Tang, Yexiong Li, Jianqiang Cai, Jing JinAbstractHepatocellular carcinoma (HCC) is one of the most common digestive system malignant tumors. Due to the resistance to radiotherapy, the prognosis in patients with HCC is poor. Based on previous studies and online tools prediction, we hypothesized that miR-92b, which was reported to promote HCC cell proliferation, might bind to p57kip2, a well-known tumor suppressor, to modulate the radioresistance of HCC ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: February 2019Source: Biomedicine &Pharmacotherapy, Volume 110Author(s): Michał Jóźwiak, Marta Struga, Piotr Roszkowski, Agnieszka Filipek, Grażyna Nowicka, Wioletta OlejarzAbstractAlloxanthoxyletin, a natural occurring pyranocoumarin isolated from a number of plant sources, such as family of Rutaceae, and its synthetic derivatives show cytotoxic and antitumor activities. In the present study new eleven esters of alloxanthoxyletin and fatty acids were synthesized and evaluated for their anticancer toxicity. The structures of the compounds were confirmed by Proton Nuclear Magnetic Resonance (1...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: February 2019Source: Biomedicine &Pharmacotherapy, Volume 110Author(s): Wei Jiang, Dong-Bo Wu, Si-Yu Fu, En-Qiang Chen, Hong Tang, Tao-You ZhouAbstractTNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL has recently been suggested as a potential therapeutic target in hepatocellular carcinoma (HCC) because it promotes apoptosis in cancer cells. Furthermore, studies on the role of TRAIL in liver injury have reported that TRAIL plays an e...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 8 November 2018Source: Biomedicine &PharmacotherapyAuthor(s): Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi IshiharaAbstractRose oil has traditionally been used to treat psychiatric disorders, but the scientific basis of this treatment remains poorly understood. The main odor component of rose oil is 2-phenylethanol (2-PE), but the neuropsychological effects of 2-PE have not been investigated in detail. Thus, we aimed to investigate the effects of 2-PE on mouse behavior. We first investigated whet...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 7 November 2018Source: Biomedicine &PharmacotherapyAuthor(s): Shengli Wang, Shuguang Zuo, Zhigang Liu, Xinying Ji, Zhenqiang Yao, Xinchun Wang
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 11 December 2018Source: The Saudi Dental JournalAuthor(s): William Becker, Leonard Tibbetts
Source: The Saudi Dental Journal - Category: Dentistry Source Type: research
Publication date: December 2018Source: The Journal of Prosthetic Dentistry, Volume 120, Issue 6Author(s): Parissa Nassary Zadeh, Nina Lümkemann, Beatrice Sener, Marlis Eichberger, Bogna StawarczykAbstractStatement of problemThe development of zirconia materials with optimized properties has been rapid, and studies comparing the mechanical and optical properties of recently introduced zirconia with lithium disilicate materials are limited.PurposeThe purpose of this in vitro study was to compare the mechanical and optical properties of cubic/tetragonal zirconia materials with those of a lithium disilicate ceramic.M...
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
Publication date: December 2018Source: The Journal of Prosthetic Dentistry, Volume 120, Issue 6Author(s): Carine Matthys, Stijn Vervaeke, Wolfgang Jacquet, Hugo De BruynAbstractStatement of problemThe influence of the mandibular resorption profile on clinical outcome after converting a conventional complete denture into a Locator-retained implant overdenture is unknown.PurposeThe purpose of this prospective study was to assess the oral health-related quality of life (OHRQoL) and prosthetic maintenance of mandibular overdentures on 2 Locator abutments in relation to the resorption degree of the edentulous mandible.Material ...
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
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