Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution

A growing number of single-nucleotide polymorphisms (SNPs) have been associated with body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility loci are uniform across the BMI distribution remains unclear. We studied the effects of 37 BMI-associated SNPs in 75,230 adults of European ancestry across BMI percentiles by using conditional quantile regression (CQR) and meta-regression (MR) models. The effects of nine SNPs (24%) —rs1421085 (FTO; p = 8.69 × 10−15), rs6235 (PCSK1; p = 7.11 × 10−6), rs7903146 (TCF7L2; p = 9.60 × 10−6), rs11873305 (MC4R; p = 5.08 × 10−5), rs12617233 (FANCL; p = 5.30 × 10−5), rs11672660 (GIPR; p = 1.64 × 10−4), rs997295 (MAP2K5; p = 3.25 × 10−4), rs6499653 (FTO; p = 6.23 × 10−4), and rs3824755 (NT5C2; p = 7.90 × 10−4)—increased significantly across the sample BMI distribution.

Source: The American Journal of Human Genetics - December 7, 2017 Category: Genetics & Stem Cells Authors: Arkan Abadi, Akram Alyass, Sebastien Robiou du Pont, Ben Bolker, Pardeep Singh, Viswanathan Mohan, Rafael Diaz, James C. Engert, Salim Yusuf, Hertzel C. Gerstein, Sonia S. Anand, David Meyre Tags: Article Source Type: research