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Brucellosis: Patient History Is the Key Brucellosis: Patient History Is the Key

The symptoms are nonspecific, so patient history is critical to the identification of brucellosis.CDC Expert Commentary
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Infectious Diseases Commentary Source Type: news

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AbstractUsing a cross-sectional survey, we determined the prevalence and risk factors associated with bovine brucellosis in herds under extensive production system in southwestern Nigeria. Antibodies toBrucella species in serum samples were tested using the Rose Bengal test (RBT) and competitive enzyme-linked immunosorbent assay (cELISA); for milk, the milk ring test (MRT) and indirect-ELISA (i-ELISA) were used. Questionnaire was administered to cattle herdsmen to determine factors predisposing the animals to bovine brucellosis. Data were analyzed using STATA 12. From 513 serum and 635 milk samples tested among 120 herds, ...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
This study aimed at determining the significance ofBrucella spp. andCoxiella burnetti infections in cattle. A total of 400 sera samples (139 from males and 261 from females cattle) were collected and screened for brucellosis using Rose Bengal Plate test (RBPT) and competitive enzyme linked immunosorbent assay (cELISA) for brucellosis and indirect enzyme-linked immunosorbent assay (iELISA) for Q fever. A structured questionnaire was used to collect data on the sampled animals from the study population. Data were analyzed to determine association and risk factors. Sera analysis revealed that, 18.5 and 6.8% were seropositive ...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
MULTIPLE-LOCUS VARIABLE-NUMBER TANDEM REPEAT ANALYSIS OF BRUCELLA ISOLATES FROM THAILAND. Southeast Asian J Trop Med Public Health. 2017 Jan;48(1):124-42 Authors: Kumkrong K, Chankate P, Tonyoung W, Intarapuk A, Kerdsin A, Kalambaheti T Abstract Brucellosis-induced abortion can result in significant economic loss to farm animals. Brucellosis can be transmitted to humans during slaughter of infected animals or via consumption of contaminated food products. Strain identification of Brucella isolates can reveal the route of transmission. Brucella strains were isolated from vaginal swabs of farm animal, co...
Source: Southeast Asian Journal of Tropical Medicine and Public Health - Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research
MULTILOCUS SEQUENCE TYPING OF BRUCELLA ISOLATES FROM THAILAND. Southeast Asian J Trop Med Public Health. 2016 Nov;47(6):1270-87 Authors: Chawjiraphan W, Sonthayanon P, Chanket P, Benjathummarak S, Kerdsin A, Kalambhaheti T Abstract Although brucellosis outbreaks in Thailand are rare, they cause abortions and infertility in animals, resulting in significant economic loss. Because Brucella spp display> 90% DNA homology, multilocus sequence typing (MLST) was employed to categorize local Brucella isolates into sequence types (STs) and to determine their genetic relatedness. Brucella samples were isolate...
Source: Southeast Asian Journal of Tropical Medicine and Public Health - Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research
This study evaluated the potential of molecular tools based on PCR and LAMP using primers targeting the insertion sequence IS711 for Brucella detection in three groups of dogs (infected, non-infected and suspected of brucellosis), which were determined according to the results of blood culturing and clinical examination. The performance of the three diagnostic tests was also determined using McNemar test and Kappa coefficient. The proportion of positive samples detected by blood culturing, PCR and LAMP was respectively 31.57% (18/57), 33.34% (19/57), and 14.03% (8/57). The agreement between blood culturing and PCR was almo...
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
This study determined the proportional seropositivity of two zoonotic diseases: Q fever (causative agentCoxiella burnetii) and Brucellosis (Brucella species) in goats across five provinces (Vientiane Capital, Xayaboury, Xiengkhuang, Savannakhet and Attapeu). A total of 1458 goat serum samples were tested using commercial indirect ELISA for both pathogens, plus Rose Bengal agglutination test for Brucellosis. Overall individual seropositivity ofC.burnetii was 4.1% andBrucella spp. was 1.4%. A multiple logistic regression model identified that province (Vientiane Capital, p = 0.05), breed (introduced Boer mixed breed, p = 0.0...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Publication date: Available online 11 April 2018 Source:IDCases Author(s): Meshal Alyousef, Rabia Aldoghaither Spinal epidural abscess (SEA) is an extremely rare and disastrous musculoskeletal complication of spondylodiscitis and sacroilitis secondary to brucellosis infection. Few case reports and retrospective studies have been published reporting patients with epidural abscesses mainly lumbar, and thoracic while cervical abscess are rare. Management of spinal epidural abscess due to Brucella species is not standard and remains controversial. To the best of our knowledge this is the first case of brucellar cervical epidu...
Source: IDCases - Category: Infectious Diseases Source Type: research
We report here the successful immunotherapy of bovine Brucellosis by phage lysates of RB51 (RL) and S19 (SL). The SL induced strong antibody response and RL stimulated CMI.In vitro restimulation of leukocytes from RL immunized cattle induced interferon gamma production. A single subcutaneous dose of 2 ml of cocktail lysate (both RL and SL), eliminated live virulentBrucella from Brucellosis affected cattle with plasma level ofBrucella specific 223 bp amplicon undetectable by RT-PCR and blood negative for liveBrucella by culture in 3 monthspost-immunization. This is the first report on minimally invasive monitoring of the ef...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
In this study, we were interested in examining the immunogenicity and protective efficacy of Omp25c against Brucella infections. Recombinant unlipidated form of this antigen (rOmp25c) produced, upon intraperitoneal immunization in BALB/c mice along with Freund’s adjuvant, was confirmed to be highly immunogenic; leading to high IgG antibody titers during the study duration. The IgG2a/IgG2b ratio of anti-rOmp25c antibodies revealed elicitation of Th2 based humoral immunity. Lymphocyte proliferation study divulged induction of specific memory response and secretion of both Th1-type (IFN-γ, GM-CSF and TNF-α) ...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Authors: Bukhari EE Abstract Brucellosis remains the most common bacterial zoonotic infection in many countries worldwide. Despite being long recognized and controllable, the disease still causes substantial morbidity, affecting especially the young population. The aim of this review is to provide insight to the epidemiology, etiology, clinical features, diagnosis, and management of childhood brucellosis. PMID: 29619483 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
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