With latest drug trial, Sage catapults into top 5 most valuable Mass. biotechs

Sage Therapeutics saw its market cap jump more than $2.5 billion on Thursday after announcing that one of its depression drugs had aced a mid-stage trial, vaulting the Cambridge-based company into the state ’s top five most valuable biotechs. Sage (Nasdaq: SAGE) announced that the drug, called SAGE-217, had helped to reduce symptoms of major depressive disorder in the Phase 2 study. The 187-employee company now hopes to move the drug into a Phase 3 trial before potentially seeking approval from…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Publication date: Available online 18 October 2018Source: Journal of Molecular LiquidsAuthor(s): Xianghong Li, Shuduan Deng, Tong Lin, Xiaoguang Xie, Xin XuAbstractThe inhibition effect of triazolyl blue tetrazolium bromide (TBTB) on cold rolled steel (CRS) in three chlorinated acetic acids of monochloroacetic acid (ClCH2COOH), dichloroacetic acid (Cl2CHCOOH) and trichloroacetic acid (Cl3CCOOH) was studied by weight loss, potentiodynamic polarization curves, electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM) methods. Meanwhile, the adsorption mechanism of TBT+ (organic part of TBTB) was the...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 18 October 2018Source: Comparative Biochemistry and Physiology Part D: Genomics and ProteomicsAuthor(s): Aimee Lee S. Houde, Angela D. Schulze, Karia H. Kaukinen, Jeffrey Strohm, David A. Patterson, Terry D. Beacham, Anthony P. Farrell, Scott G. Hinch, Kristina M. MillerAbstractThere is a paucity of information on the physiological changes that occur over the course of salmon early marine migration. Here we aim to provide insight on juvenile Coho salmon (Oncorhynchus kisutch) physiology using the changes in gene expression (cGRASP 44K microarray) of four tissues (brain, gill, muscle, and ...
Source: Comparative Biochemistry and Physiology Part D: Genomics and Proteomics - Category: Genetics & Stem Cells Source Type: research
Support from family and community appear to shield Latinos from rising suicide rates, researchers say.Kaiser Health News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news
Authors: Moreira de Sousa J, Moreira CA, Telles-Correia D Abstract INTRODUCTION: The aim of the study is to assess the prevalence of anxiety and depressive symptoms in Portuguese medical students compared to students of other faculties, and the possible impact those symptoms have on academic performance. MATERIAL AND METHODS: A cross-sectional study was conducted in a sample of 750 students: 512 medical students and 238 nonmedical students. All students anonymously completed a socio-demographic survey and the Hospital Anxiety and Depression Scale (HADS). Statistical analysis was performed using t...
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
Publication date: Available online 18 October 2018Source: Journal of Psychiatric ResearchAuthor(s): Steven D. Targum, Beth R. Cameron, Ludvina Ferreira, I. David MacDonaldAbstractWe conducted a 6-week double-blind, placebo-controlled, augmentation study comparing the efficacy and safety of MSI-195 800 mg (a proprietary formulation of S-adenosylmethionine) or placebo added to ongoing antidepressant medication (ADT) in acutely depressed subjects with Major Depressive Disorder (MDD) who had experienced an inadequate response to their ongoing ADT (The Horizon Study, ClinicalTrials.gov NCT01912196).There were 234 eligible s...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
It is common for people with diabetes to experience fatigue. Causes can include high blood sugar levels, depression, being overweight, and other related health conditions. Controlling blood sugar levels and lifestyle changes can help a person reduce fatigue. Learn more here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Diabetes Source Type: news
Conditions:   Anxiety Generalized;   Quality of Life;   Depression Intervention:   Behavioral: PISCES Sponsors:   George Demiris, PhD;   National Institute of Nursing Research (NINR) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Anxiety Disorders;   Depression;   Electronic Media Intervention:   Behavioral: Electronic Media Enhanced Sponsors:   Mclean Hospital;   The Once Upon a Time Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
SSRIs may amplify the living environment of patients with MDD so that those in more positive situations are more likely to remit compared with their counterparts living in less favorable conditions.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Business of Medicine News Source Type: news
Publication date: Available online 18 October 2018Source: Comparative Biochemistry and Physiology Part A: Molecular &Integrative PhysiologyAuthor(s): Samantha M. Logan, Cheng-Wei Wu, Kenneth B. StoreyAbstractHibernating mammals use strong metabolic rate depression and a reduction in body temperature to near-ambient to survive the cold winter months. During torpor, protein synthesis is suppressed but can resume during interbout arousals. The current study aimed to identify molecular targets responsible for the global suppression of protein synthesis during torpor as well as possible mechanisms that could allow for selec...
Source: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology - Category: Biochemistry Source Type: research
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