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With latest drug trial, Sage catapults into top 5 most valuable Mass. biotechs

Sage Therapeutics saw its market cap jump more than $2.5 billion on Thursday after announcing that one of its depression drugs had aced a mid-stage trial, vaulting the Cambridge-based company into the state ’s top five most valuable biotechs. Sage (Nasdaq: SAGE) announced that the drug, called SAGE-217, had helped to reduce symptoms of major depressive disorder in the Phase 2 study. The 187-employee company now hopes to move the drug into a Phase 3 trial before potentially seeking approval from…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Authors: Salpekar J PMID: 29225525 [PubMed]
Source: Epilepsy Currents - Category: Neurology Tags: Epilepsy Curr Source Type: research
[Abstract unavailable] Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
The objective of this study was to investigate how depressive symptoms are prospectively associated with subsequent absence, whether caused by illness or accidents, among ma...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
AIM: The aim of this study was to investigate the feasibility and cost-utility of a school-based cognitive-behavioral (CB) depression prevention program. METHODS: A quasi-experimental trial with an intervention group and a control group, with follo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
"Complex suicide" is a term referring to the suicidal pattern in which more than one suicidal method is applied in the purpose of inducing death. The present paper aims to review complex suicide literature shortly and investigate an unusual planned complex...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Poisoning Source Type: news
OBJECTIVE: The purpose of this study was to examine links across romantic partner relational victimization, depressive symptoms, and drinking problems during young adulthood. We were interested in evaluating depression as a mediator of the association betw...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Okay. I need help. I had a discussion with one of my interviewers about "Psuedodementia". I was wondering if this is actually a real diagnosis or is this depression unmasking real dementia? I always thought it was depression that was so severe that it causes a clinical picture of dementia. However, it isn't progressive or stepwise, usually has a proximal stressor and no other medical causes can be ruled in. What do people think?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
Depression affects one in four women and one in six men. It is the cause of more than $200 billion in lost productivity, work absenteeism, and disability and health care costs annually, and is believed to contribute to roughly a million suicides worldwide each year.These were among the statistics experts shared at aZ ócalo/UCLA discussion on depression and the efforts UCLA is undertaking to better diagnose and treat it. The event, which was held Dec. 11, drew a packed house to the National Center for the Preservation of Democracy in downtown Los Angeles.The evening featured panelists Gene Block, UCLA chancellor; &nb...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
CONCLUSIONS: CFT appears effective in improving QoL and depression in PwD and reducing RR in PwD and spouses. CFT reduces anxiety and depression in most PwD and spouses with borderline to abnormal symptoms. CLINICAL IMPLICATIONS: This study indicates benefits of a group-CFT intervention delivered to people with a range of dementia diagnosis and their spouses. The service should investigate whether individuals in greater distress are not accessing the group and improve engagement. PMID: 29227742 [PubMed - as supplied by publisher]
Source: Clinical Gerontologist - Category: Geriatrics Tags: Clin Gerontol Source Type: research
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