With latest drug trial, Sage catapults into top 5 most valuable Mass. biotechs

Sage Therapeutics saw its market cap jump more than $2.5 billion on Thursday after announcing that one of its depression drugs had aced a mid-stage trial, vaulting the Cambridge-based company into the state ’s top five most valuable biotechs. Sage (Nasdaq: SAGE) announced that the drug, called SAGE-217, had helped to reduce symptoms of major depressive disorder in the Phase 2 study. The 187-employee company now hopes to move the drug into a Phase 3 trial before potentially seeking approval from…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Authors: Ibrahim E, Sultan W, Helal S, Abo-Elwafa H, Abdelaziz A Abstract BACKGROUND: Conscious sedation is usually required during flexible bronchoscopy. Sedation should be achieved without respiratory depression or loss of consciousness. The present study was designed to evaluate the effect of pregabalin pre-medication on reducing the amount of sedatives and to show its advantages for patients undergoing flexible bronchoscopy with dexmedetomidine. METHODS: Seventy patients undergoing elective flexible bronchoscopy were randomly divided into two groups of 35 patients each. All patients received premedication o...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Authors: Wirz-Justice A, Ajdacic V, Rössler W, Steinhausen HC, Angst J Abstract The prevalence of autumn/winter seasonality in depression has been documented in the longitudinal Zurich cohort study by five comprehensive diagnostic interviews at intervals over more than 20 years (N = 499). Repeated winter major depressive episodes (MDE-unipolar + bipolar) showed a prevalence of 3.44% (5× more women than men), whereas MDE with a single winter episode was much higher (9.96%). A total of 7.52% suffered from autumn/winter seasonality in major and minor depressive mood states. ...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
CONCLUSIONS: These findings correspond with the idea that mindfulness reduces incongruencies between implicit and explicit emotional responses. We found preliminary evidence for this effect for negative emotional responses. There was suggestive evidence that congruence arose from the alignment of explicit responses (which became less stable) to implicit responses (which remained stable). Studying the interplay between implicit and explicit processes may shed light on the working mechanisms of clinical-psychological interventions. PMID: 30022567 [PubMed - as supplied by publisher]
Source: Clinical Psychology and Psychotherapy - Category: Psychiatry Tags: Clin Psychol Psychother Source Type: research
Authors: Rizo CF, Wretman CJ, Macy RJ, Guo S, Ermentrout DM Abstract Female intimate partner violence (IPV) survivors who are their children's primary caregivers are often mandated to services by child protection services (CPS) and/or the courts. Unfortunately, scant evidence exists regarding mandated programs for CPS- and/or court-involved IPV survivors, particularly the mental health outcomes of such programs. Two human service agencies in the southeastern United States collaborated to develop and implement a novel 13-week intervention to address the needs of these mothers' as related to safety, parenting, and me...
Source: The American Journal of Orthopsychiatry - Category: Psychiatry Tags: Am J Orthopsychiatry Source Type: research
Abstract: Patients with diabetes are sometimes overwhelmed with the burden of self-care associated with the disease. Although it may seem appropriate to diagnose patients experiencing such emotional burdens with depression, the literature over the past 20 years has matured the concept of diabetes distress, which may more accurately describe the phenomenon.
Source: The Nurse Practitioner - Category: Nursing Tags: Feature: DIABETES DISTRESS Source Type: research
Publication date: Available online 20 July 2018Source: EXPLOREAuthor(s): Elizabeth McDonald, Raymond Teets, Caroline Ortiz, Christine Gilchrist, Eve Waltermaurer, Elidania Perez, Benjamin KliglerAbstractIntroductionIrritable bowel syndrome (IBS) is a chronic debilitating functional gastrointestinal disorder that affects a large proportion of the general population. Dietary and mind-body approaches have shown some effectiveness in reducing IBS symptoms.ObjectivesThe purpose of this project was to test the feasibility of a low cost, group-oriented integrative medicine approach to IBS, and to explore whether such an approach ...
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
ConclusionsThe Caregiver Support Team was positively received. The organization received budgetary support from our hospital to disseminate the program system-wide. Additional interventions are needed to overcome the root cause of workplace stressors. A formal link between Risk Management is being developed to identify cases which warrant emotional (vs. clinical only or both) debriefing/group processing.Graphical Abstract
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
The objectives of this study were (1) to describe home health care (HHC) nurses' perception of and care processes related to geriatric depression and frailty, and (2) to identify barriers to care delivery for older persons with these two conditions. Ten semi-structured interviews were conducted with HHC nurses, and 16 HHC nursing visits to 16 older patients (≥65 years) were observed. Mixed method analysis showed that HHC nurses did not routinely assess for frailty and depression. Major barriers to care delivery included insufficient training, documentation burden, limited reimbursement, and high caseload. Addressin...
Source: Journal of Community Health Nursing - Category: Nursing Tags: J Community Health Nurs Source Type: research
ConclusionsOverall, the findings provide evidence for good psychometric properties of the Mandarin Chinese version of the Y-BOCS-SR. Future research is needed to better explore the factor structure of the measure, examine other types of reliability and validity, and to increase the generalizability of the findings.
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
ConclusionThe 5-HTTLPR polymorphisms predicted short-term risk of suicidal reattempt independently of age and sex. L-carriers have almost three times more risk of relapse when compared with SS carriers.
Source: European Psychiatry - Category: Psychiatry Source Type: research
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