CME ‐1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide‐stimulated macrophages through ceramide‐initiated protein phosphatase 2A activation

In conclusion, CME‐1 suppressed iNOS expression by up‐regulating ceramide‐induced PP2A activation and reducing ROS production in LPS‐stimulated macrophages. CME‐1 is a potential therapeutic agent for treating inflammatory diseases.

Source: Journal of Cellular and Molecular Medicine - December 1, 2017 Category: Molecular Biology Authors: Joen ‐Rong Sheu, Zhih‐Cherng Chen, Ming‐Jen Hsu, Shwu‐Huey Wang, Kuo‐Wei Jung, Wei‐Fan Wu, Szu‐Han Pan, Ruei‐Dun Teng, Chih‐Hao Yang, Cheng‐Ying Hsieh Tags: Original Article Source Type: research