Alzheimer's falls 11% for every year spent in education

Researchers from Cambridge University found that the longer someone spends in school and university, the lower their risk of developing the condition.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Authors: de Castro AA, Soares FV, Pereira AF, Polisel DA, Caetano MS, Leal DHS, da Cunha EFF, Nepovimova E, Kuca K, Ramalho TC Abstract INTRODUCTION: Alzheimer's disease (AD) is the most common cause of dementia. Clinical progress in this pathogenesis field has drawn the attention of researchers, stimulating the investigation of novel treatment methods. Current therapies that deal with cholinesterase inhibitors and/or NMDA antagonists have shown a modest symptomatic potential, increasing the need for research into more efficient therapeutics. The goal of this review is to summarize the advances in, and the potential o...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Authors: Weaver DF PMID: 30998498 [PubMed - in process]
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
Publication date: 20–26 April 2019Source: The Lancet, Volume 393, Issue 10181Author(s): Richard Barnett
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 19 April 2019Source: Alzheimer's &DementiaAuthor(s): Michel Goedert
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: Available online 20 April 2019Source: Neurochemistry InternationalAuthor(s): Leticia Rodrigues, Krista Minéia Wartchow, Lucas Zingano Suardi, Barbara Carolina Federhen, Nicholas Guerini Selistre, Carlos-Alberto GonçalvesAbstractStreptozotocin (STZ) is a glucosamine-nitrosourea commonly used to induce long-lasting models of diabetes mellitus and Alzheimer's disease. Direct toxicity of STZ on the pancreas and kidneys has been well characterized, but the acute effect of this compound on brain tissue has received less attention. Herein, we investigated the acute and direct toxicity of STZ on fre...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
Environmental stimuli attack the skin daily resulting in oxidative stress and the generation of reactive oxygen species (ROS) and inflammation. One pathway that regulates oxidative stress in skin involves Protein phosphatase 2A (PP2A), a phosphatase that has been previously linked to Alzheimer ’s Disease and aging. Oxidative stress bursts via hydrogen peroxide (H2O2) and Ultraviolet A (UVA) treatments have previously been shown to dramatically decrease PP2A methylation in human dermal fibroblasts (HDFs), moreover, in vivo studies demonstrate that oxidative stress induces PP2A inactivati on.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Neuro-Cutaneous Biology and Inflammation Source Type: research
AbstractAlzheimer ’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activatio n is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pathology. Gal3 was highly upregulated in the brains of AD patients and 5xFAD (familial Alzheimer’s disease) mice and found specifically expressed in microglia associated with Aβ plaques. Single-nucle...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
The thymus is vital to the function of the adaptive immune system. It is where T cells mature after their creation as thymocytes in the bone marrow, acquiring the necessary tolerance and function to venture forth into the body and defend it against pathogens, cancerous cells, and senescent cells. Unfortunately the thymus declines in size with age, its active tissue replaced with fat, in a process known as thymic involution. The consequence of this is an ever smaller supply of new T cells, ready to tackle threats. The adaptive immune system becomes ever less functional as a result, its limited set of cells uselessly special...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Publication date: 1 July 2019Source: Journal of Molecular Liquids, Volume 285Author(s): Asra Nasir Khan, Md Nadir Hassan, Rizwan Hasan KhanAbstractMetal ions play a vital role in the aggregation of proteins by interfering with their correct folding, thereby affecting protein homeostasis and cell viability, leading to neurodegenerative diseases like Alzheimer's and Parkinson's. Development of therapeutics against protein misfolding diseases has become one of the widely studied areas of research. Till date, all advances in neurodegenerative diseases' therapeutics help symptomatically but do not prevent the root cause of the ...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
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