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Flow Cytometric Analysis of Peripheral Blood Neutrophil Myeloperoxidase Expression and Myelodysplastic Syndromes

Conditions:   Myelodysplastic Syndromes;   Chronic Myelomonocytic Leukemia Intervention:   Diagnostic Test: Flow cytometry analysis of neutrophil myeloperoxidase expression Sponsor:   University Hospital, Grenoble Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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(In)convenience of adding age and comorbidities to prognostic models in myelodysplastic syndromes, Published online: 22 February 2018; doi:10.1038/s41375-018-0064-6(In)convenience of adding age and comorbidities to prognostic models in myelodysplastic syndromes
Source: Leukemia - Category: Hematology Authors: Source Type: research
Conclusions Multiparametric analyses of new automated parameters are useful for discriminating MDS from non-clonal cytopenia.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Conditions:   Transplant-Related Hematologic Malignancy;   Leukemia, Acute;   Myelodysplastic Syndromes;   Graft Vs Host Disease;   Fungal Infection Interventions:   Drug: Conditioning treatment " Thiotepa-Treosulfan-Fludarabine " ;   Procedure: PBSC graft;   Drug: GvHD prophylaxis;   Drug: Primary antifungal prophylaxis Sponsor:   Ciceri Fabio Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Transplant-Related Hematologic Malignancy;   Leukemia, Acute;   Myelodysplastic Syndromes;   Graft Vs Host Disease;   Fungal Infection Interventions:   Drug: Conditioning treatment " Thiotepa-Treosulfan-Fludarabine " ;   Procedure: PBSC graft;   Drug: GvHD prophylaxis;   Drug: Primary antifungal prophylaxis Sponsor:   Ciceri Fabio Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Transplant-Related Hematologic Malignancy;   Leukemia, Acute;   Myelodysplastic Syndromes;   Graft Vs Host Disease;   Fungal Infection Interventions:   Drug: Conditioning treatment " Thiotepa-Treosulfan-Fludarabine " ;   Procedure: PBSC graft;   Drug: GvHD prophylaxis;   Drug: Primary antifungal prophylaxis Sponsor:   Ciceri Fabio Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Transplant-Related Hematologic Malignancy;   Leukemia, Acute;   Myelodysplastic Syndromes;   Graft Vs Host Disease;   Fungal Infection Interventions:   Drug: Conditioning treatment " Thiotepa-Treosulfan-Fludarabine " ;   Procedure: PBSC graft;   Drug: GvHD prophylaxis;   Drug: Primary antifungal prophylaxis Sponsor:   Ciceri Fabio Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Transplant-Related Hematologic Malignancy;   Leukemia, Acute;   Myelodysplastic Syndromes;   Graft Vs Host Disease;   Fungal Infection Interventions:   Drug: Conditioning treatment " Thiotepa-Treosulfan-Fludarabine " ;   Procedure: PBSC graft;   Drug: GvHD prophylaxis;   Drug: Primary antifungal prophylaxis Sponsor:   Ciceri Fabio Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion.Azacitidine effects in these patients, most with non‐del(5q) LR‐MDS, were promising and generally similar to those reported for lenalidomide in similar patients. The choice of initial therapy is important because most patients eventually stop responding to front‐line therapy and alternatives are limited.Implications for Practice.Lower‐risk myelodysplastic syndromes (LR‐MDS) are primarily characterized by anemia. After erythropoiesis‐stimulating agent (ESA) failure, lenalidomide and hypomethylating agents are the only remaining treatment options for most patients. This meta‐analysis of 233 azacitidi...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Leukemias, Academia-Pharma Intersect, Hematologic Malignancies ‐ Pharma Intersect: Hematologic Malignancies Source Type: research
Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome, Published online: 14 February 2018; doi:10.1038/s41379-018-0014-xSecondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome
Source: Modern Pathology - Category: Pathology Authors: Source Type: research
Conclusions: Patients with intestinal BD demonstrated a higher risk of hematologic cancer, especially leukemia, than the general population. Furthermore, women with intestinal BD showed a higher risk of all cancers. PMID: 29429154 [PubMed - as supplied by publisher]
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
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