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Safety of IV Ferric Carboxymaltose vs Oral Iron in CKD Safety of IV Ferric Carboxymaltose vs Oral Iron in CKD

What does the evidence tell us about the safety of IV iron therapy in patients with CKD?Nephrology Dialysis Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

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We report a rare occurrence of incisional hernia attributable to internal wound dehiscence after PD catheter placement in a patient on sirolimus.A 34-year-old Latino American man was started on PD training 4 weeks after placement of a PD catheter. Soon after completing training, he developed a large soft bulge close to the PD catheter, with expansile cough impulse suggestive of an incisional hernia filled with peritoneal dialysate. The size of the bulge would decrease after the dialysate was drained. No external leak of dialysate was evident along the exit site.Because of the size of the hernia and the history of it fillin...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research
The week of April 23-27 has been designated as National Pediatric Transplant Week.  This week is to bring attention to the great need for organ donations and to honor  donors and their families whose incredibly selfless gift has given someone the gift of life.While most of us will never experience the need for a transplant, there are many of us who know someone who has a debilitating condition such as kidney dialysis that are in need of a transplant.Right now there are almost 2,000 children on the national transplant list.  Those needing hearts, lungs, eyes, tissue, liver, kidney, or some other body part are...
Source: Pediatric Health Associates - Category: Pediatrics Tags: Volunteer Opportunities Source Type: news
ConclusionsIn the past decade, the incidence of dialysis has stabilized in both the general population and in diabetics in whom it remains far higher by comparison. Also mortality rates are higher, with a worse prognosis for T1DM. Diabetes poses a barrier to allotransplantation, and efforts should be made to overcome this limitation.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
This editorial describes a patient who was cared for by the author. The patient developed end-stage kidney disease in the United States at the age of 17 but was denied kidney transplantation due to lack of insurance because of her immigration status. With the enactment of the Deferred Action for Childhood Arrivals (DACA) program, the patient was able to obtain a job and health insurance. The patient then received a kidney transplant when she was 27 years, after undergoing peritoneal dialysis for 10 years. The editorial describes how the DACA program improves the care of undocumented immigrants to the United States who are ...
Source: Nephron - Category: Urology & Nephrology Source Type: research
A 44-year-old male patient presented with recurrent urinary tract infections (urine cultures negative) for 2 years. He was diagnosed as having a urethral stricture, and he underwent dilatations. However, his renal functions deteriorated, and he developed chronic kidney disease (CKD) requiring dialysis and transplantation. Pretransplant workup revealed 4 –5 leukocytes on urine examination, proteinuria (0.2 g/d), and a serum creatinine level of 6.7 mg/dl. Magnetic resonance imaging of his kidneys showed multifocal hyperintense lesions in both.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
We thank Fusaro and her colleagues for their comments.1 We concur that there is a sound need for large, well-designed clinical studies to assess the prevalence, risk factors, treatment, and outcome of vertebral fractures in patients with chronic kidney disease (CKD). In our review,2 we did not include quantitative vertebral morphology as assessed by MorphoXpress software to quantify vertebral fractures in CKD. The assessment of vertebral fractures by quantitative vertebral morphology in patients on dialysis and renal transplant recipients resulted in the validation of the tool in osteoporotic patients of the general popula...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
It is well recognized that the shortage of available kidneys has resulted in long wait times for dialysis patients seeking transplantation and that many patients die before receiving an allograft. Yet, the data presented by Reese et  al.,1 in their early, thoughtful proposal to begin considering transplanting hepatitis C virus (HCV)–positive kidneys, reveal that in the United States between 2005 and 2014, 4144 kidneys from 3273 deceased donors with hepatitis C antibody were discarded. With the recent development of highly ef fective, well-tolerated oral agents to treat HCV infection, it would seem desirable to t...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
Abstract Brain death is associated with significant inflammation within the kidneys, which may contribute to reduced graft survival. Direct peritoneal resuscitation (DPR) has been shown to reduce systemic inflammation after brain death. To determine its effects, brain dead rats were resuscitated with normal saline (targeted intravenous fluid, TIVF) to maintain a mean arterial pressure of 80 mmHg and DPR animals also received 30cc of intraperitoneal peritoneal dialysis solution. Rats were euthanized at zero, two, four, and six hours after brain death. Pro-inflammatory cytokines were measured using ELISA. Levels of ...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
Conclusion: PrOD regimen demonstrated an excellent efficacy and good tolerability. Both prospective adjustment of concomitant medication and further on-treatment adjustment allowed for a safe treatment course.Kidney Blood Press Res 2018;43:594 –605
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research
DiscussionDelayed graft function is a major issue after renal transplantation, impeding long-term prognosis. Cyclosporine A pretreatment in deceased donors could improve the outcome of patients after renal transplantation.Trial registrationClinicalTrials.gov, ID:NCT02907554 Registered on 20 September 2016.  
Source: Trials - Category: Research Source Type: clinical trials
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