Safety of IV Ferric Carboxymaltose vs Oral Iron in CKD Safety of IV Ferric Carboxymaltose vs Oral Iron in CKD

What does the evidence tell us about the safety of IV iron therapy in patients with CKD?Nephrology Dialysis Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

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This article reviews the clinical case for a special emphasis on this transition period, reviews published literature regarding prior transitional care programs, and proposes a novel iteration of the first 30 days of dialysis care: the transitional care unit (TCU). The goal of a TCU is to improve awareness of all aspects of renal replacement therapy, including modalities, access, transplantation options, and nutritional and psychosocial aspects of the disease. This enables patients to make truly informed decisions regarding their care. The TCU model is open to all patients, including incident patients with end-stage renal ...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionsSeveral modifiable and nonmodifiable factors are associated with early technique failure in PD. Targeted interventions should be considered in high-risk patients to avoid the consequences of an unplanned transfer to hemodialysis therapy or death.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionThis study confirms the comparable safety profiles of originator and biosimilar epoetin alfa drugs when used in patients receiving dialysis.
Source: BioDrugs - Category: Drugs & Pharmacology Source Type: research
AbstractPurpose of ReviewThe choice of optimum transplant in a patient with type 1 diabetes mellitus (T1DM) and chronic kidney disease stage V (CKD V) is not clear. The purpose of this review was to investigate this in more detail —in particular the choice between a simultaneous pancreas-kidney transplantation (SPKT) and living donor kidney transplantation (LDKT), including recent evidence, to aid clinicians and their patients in making an informed choice in their care.Recent FindingsAnalyses of large databases have recently shown SPKT to have better survival rates than a LDKT in the long-term, despite an early incre...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
Abstract BACKGROUND: Clinical studies have demonstrated that, after renal transplantation (TX), testosterone deficiency (TD) at the time of the procedure is independently associated with lower survival of the patient and graft. However, data between TD and the functional CAG polymorphism of the androgen receptor promoter (AR) are discordant. We investigated the prevalence of TD and its association with body composition, biochemical parameters, the Aging Males' Symptoms rating scale (AMS) domains and AR polymorphism. METHODS: In 112 TX patients, we assessed the AMS, biochemical/hormonal (FSH/LH/TT) anthropomet...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
Conclusions: Fatigue was predictive of an increased risk of death and decreased likelihood of transplantation among patients, possibly through distress, impaired functioning, and its consequences, rather than clinical and inflammatory markers. PMID: 30020399 [PubMed - as supplied by publisher]
Source: Annals of Behavioral Medicine - Category: Psychiatry & Psychology Authors: Tags: Ann Behav Med Source Type: research
We present here an overview of the needs and requirements for human leukocyte antigen (HLA) matching, explain and explore the potential benefits of epitope matching, and discuss the benefits of allele-level high-resolution matching at all HLA loci, i.e. HLA-A, -B, -DR, -DQ and -DP, for donor selection needs during renal transplantation.Recent FindingsDonor recipient HLA matching has a substantial impact on organ transplantation by prolonging graft survival, minimizing rejection episodes, preventing sensitization, providing a better chance for retransplantation and reducing the percentage of deaths due to graft dysfunction....
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
CONCLUSION: Unanticipated decline in kidney function leading to unplanned start on HD contributes to the worse outcomes associated with failing to start PD. How and when we insert PD catheters appears to be key, and we have identified ways to improve our service. PMID: 29991559 [PubMed - as supplied by publisher]
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
Authors: Wishart TFL, Aw L, Byth K, Rangan G, Sud K Abstract Application of medicated honey (MH) to peritoneal dialysis (PD) catheter exit sites has been found to be as effective as intra-nasal mupirocin for preventing PD catheter-related infections (CRIs), but was associated with increased risk for CRIs in diabetics. The efficacy of topical MH as a prophylactic agent has not been compared with the exit-site application of povidone iodine (PI). This retrospective multicentre cohort study compared cumulative incidence rates of PD CRIs (peritonitis or exit-site infections) and the number of PD CRIs observed per patie...
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
Authors: Paizis IA, Mantzouratou PD, Tzanis GS, Melexopoulou CA, Darema MN, Boletis JN, Barbetseas JD Abstract BACKGROUND: Cardiovascular disease is the leading cause of mortality in renal transplant recipients (RT). Coronary artery disease (CAD) in such patients is poorly studied. METHODS: Between 2012 and 2017, 50 patients with a functioning renal graft (>6 months) were subjected to coronary angiography in our institution. They were matched (for age, gender, diabetes and indication for angiography) with 50 patients with end-stage renal disease (ESRD) undergoing chronic dialysis and 50 patients with normal ...
Source: Hellenic Journal of Cardiology - Category: Cardiology Tags: Hellenic J Cardiol Source Type: research
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