Combined blockade of renin-angiotensin-aldosterone system reduced all-cause but not cardiovascular mortality in dialysis patients: A mediation analysis and systematic review

Full blockade of renin-angiotensin-aldosterone system (RAAS) is believed to decrease morbidity and mortality of patients with chronic kidney disease. In non-dialysis patients, combined RAAS blockade with two different RAAS blockers caused more adverse events without improving survival, but its role in maintenance dialysis patients is still unclear. We conducted a systematic review and mediation analysis to investigate the efficacy and safety of combined RAAS blockade in dialysis patients.

Source: Atherosclerosis - December 6, 2017 Category: Cardiology Authors: Shao-Min Li, Wan-Bing He, Jie Chen, Qing-Qing Cai, Fei-Fei Huang, Kun Zhang, Jing-Feng Wang, Xun Liu, Hui Huang Source Type: research