Research Finds Popular Blood Pressure Drug Increases Skin Cancer Risk

This study shows a possible link between HCTZ and basal cell and squamous cell carcinomas of the skin. These are not melanomas, the deadliest form of skin cancer, but they both can pose serious health risks. This study shows an association between HCTZ and skin cancer, not proof that the medication actually causes cancer, but it’s link that needs to be studied further. In the meantime, continue to take your blood pressure medication and protect yourself from excessive sun exposure.
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local News Syndicated Local Dr. Mallika Marshall Source Type: news

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In conclusion, dermoscopy is valuable for the diagnosis of CNH as a first screening tool because of a consistent global dermoscopic configuration (daisy pattern), consisting of radially arranged white thick lines surroun ding a central rounded yellow/brown clod.
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
Conclusions: With appropriate patient selection and choosing as lowest dose per fraction as possible, HDR brachytherapy with customized surface molds yields good oncological and cosmetic results for the treatment of localized skin BCC and SCC. PMID: 29789760 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
CONCLUSION: This study has defined the rate of cSCC in a large, well defined New Zealand population, and estimated age and ethnicity adjusted incidence in New Zealand. It has demonstrated the highest incidence of cSCC in the world outside Australia. Overall positive margin rate of excised lesions was acceptable. PMID: 29771903 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Publication date: July 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1865, Issue 7 Author(s): Ewa Krzywinska, Marek Dominick Zorawski, Agnieszka Taracha, Grzegorz Kotarba, Agnieszka Kikulska, Michal Mlacki, Katarzyna Kwiatkowska, Tomasz Wilanowski The mammalian Grainyhead-like 3 (GRHL3) transcription factor is essential for epithelial development and plays a protective role against squamous cell carcinoma of the skin and of the oral cavity. A single nucleotide polymorphism (SNP) in GRHL3, rs141193530 (p.P455A), is associated with non-melanoma skin cancer in human patients. Moreover, it ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
AbstractPurpose of ReviewThe aims of this report are to review literature supporting the use of Mohs micrographic surgery for treatment of non-melanoma skin cancer and to address indications and potential limitations of this form of therapy for non-melanoma skin cancer.Recent FindingsThe first randomized controlled trial comparing standard excision to Mohs micrographic surgery for treatment of facial basal cell carcinoma has recently been published, demonstrating a lower recurrence rate after Mohs surgery compared to standard excision after a 5-year and 10-year follow-up period, supporting its use in the treatment of high-...
Source: Current Otorhinolaryngology Reports - Category: ENT & OMF Source Type: research
AbstractNon-melanoma skin cancer (NMSC) is the most prevalent type of cancer among Caucasian populations worldwide. The purpose of this work was to measure quality of life (QOL) of the patients with diagnosis of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) who were referred to our cancer clinic. During 1  year, 95 patients were selected and asked to complete Dermatology Life Quality Index (DLQI) questionnaires. Ninety-five patients with NMSC (74 men and 21 women) with mean age of 64.6 ± 12.5 participated in this cross-sectional study. From 95 patients, 75 had BCC, 15 had SCC, and 5...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
Higher nevus count is associated with increased risk of melanoma in adults. However, few studies have examined the association between nevus count and non-melanoma skin cancers. We sought to examine the association between nevus count and the risk of melanoma and non-melanoma skin cancers in three large prospective cohorts: the Nurses Health study (NHS), Nurses Health Study 2 (NHS2), and the Health Professionals Follow-up Study (HPFS). We followed up 176,317 women (74,241 from the NHS, 1986-2012; 102,076 from the NHS2, 1989-2013) and 32,383 men (from the HPFS, 1986-2012), among whom there were 1,704 incident cases of melan...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Photodynamic therapy (PDT) is used for the treatment of several types of Non-Melanoma Skin Cancer (NMSC), basal and squamous cell carcinoma (BCC and SCC, respectively). Nevertheless, PDT is not always effective and resistant cells may appear after treatment. While normal differentiated cells depend primarily on mitochondrial oxidative phosphorylation to generate energy, cancer cells change this metabolism to an aerobic glycolysis (Warburg effect), which could influence in the response to therapies.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research
In this study, memory T cells from human primary cSCCs (n=18) were characterised and compared with those from blood and non-lesional skin (NS) using flow cytometry.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research
Light hair color is an established risk factor for melanoma. Whether hair color is associated with risk of keratinocyte carcinoma, also known as non-melanoma skin cancer, has not been thoroughly studied. We prospectively examined the association between natural hair color at adulthood and risk of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) based on a total 205,307 participants from the Nurses Health Study (NHS, n=78,879), NHS II (n=89,516), and Health Professionals Follow-up Study (HPFS, n=36,912).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
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