Different microenvironment stimuli results in distinct patterns of macrophages polarization comparing elastase- and cigarette smoke - induced models of emphysema

Conclusion: Whereas the CS-induced model showed M1 and M2 phenotypes, the elastase-induced model showed a polarization for M1 and a downregulation for M2 phenotype.

Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Benini Kohler, J., Cervilha, D. A. B., Ito, J. T., Moreira, A. R., Santana, F. R., Farias, T. M., Alonso- Vale, M. I. C., Prado, C. M., Arruda Martins, M., Lopes, F. D. T. Q. S., Franca, L. E. Tags: Mechanisms of Lung Injury and Repair Source Type: research