Regulatory T cells in COPD development: How the animal model resembles the human pathophysiological features

Conclusion: This CS-induced model shows that dysregulation of T cells inflammation control mediated by Treg played a pivotal role in the COPD development.Table. Mean ± SD of CS-induced model functional, structural and inflammation profile.1stmonth3rdmonth6thmonthLm (µm)48.5±2.549.6±3.756.7±5.2*Htis (cmH20.s(1-a).kg/mL)0.97±0.150.77±0.05*0.75±0.09*Gtis(cmH20.s(1-a).kg/mL)0.17±0.010.14±0.02*0.13±0.02*CD4+T (x10–5cells/µm2)1.9±0.64.4±1.8*2.7±1.7*CD8+T (x10–5cells/µm2)1.2±0.66.1±1.6*3.7±1.9*Tregs+ (x10–5cells/µm2)4.9±1.83.4±1.22.9±1.3*IL-17+ (x10–5cells/µm2)0.9±0.72.6±1.84.5±2.2*IL-10+ (x10–5cells/µm2)0.8±0.41.7±1.11.6±1.3*P<0.02 compared with the 1<st month.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Mechanisms of Lung Injury and Repair Source Type: research