Late Breaking Abstract - IL-36 receptor agonists contribute to a pro-inflammatory milieu in smokers with and without COPD

Conclusion: IL-36α and - are produced by lung cells in vitro and are increased in smokers with and without COPD in vivo, correlating with a decline in lung function and induction of pro-inflammatory chemokines. This suggests that IL-36 agonists may play a pro-inflammatory role in the lungs of long-term smokers.

Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Kovach, M., Levanen, B., Andersson, A., Asgeirsdottir, H., Prada, M., Linden, S., Qvarfordt, I., Standiford, T., Linden, A. Tags: Allergy and immunology Source Type: research