Roflumilast N- oxide combined with sildenafil reverses cellular remodeling on IPF models

Conclusions: RNO/sildenafil combination show synergic activity, reduces mesenchymal markers expression and reverses EMT, improving anti-fibrotic effects in human AECII and fibrocytes.

Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Contreras, S., Ribera, P., Morell, A., Serrano, A., Milara, J., Milara, J. Tags: Airway Pharmacology and Treatment Source Type: research