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Brain metastasis as initial presentation of lung cancer - Impact of prognostic factors on patient survival

Background: Brain metastasis (BM) in patients with cancer is a predictor of poor prognosis and is present at initial diagnosis in 15-30% of lung cancer patients.Methods: A retrospective analysis for a period of 27 years (1989-2016) identified patients with confirmed diagnosis of lung cancer and BM at presentation.Results: 192 patients were included, 98 (51%) had brain as the only site of metastatic disease. The mean age was 62.4±11.1 years and 163 (84.9%) were male patients. Thirty (31.3%) patients had solitary metastasis and 132 (68.8%) multiple metastasis. Therapeutic modalities for BM were: whole-brain radiation therapy (132, 68.8%), radiotherapy plus surgery (8, 4.2%), surgery (7, 3.6%), radiosurgery (1, 0.5%) and no treatment (44, 22.9%). Median survival was 3.7 months.Sixty-two (32.2%) patients received palliative chemotherapy and 118 (61.5%) best supportive care. Median survival in patients who received chemotherapy was 4.7 vs. 2 months in patients who didn’t receive (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research

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Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Conclusion: Our study suggests that WWP2 may play a role in the genesis and development of glioma; it may be a potential biomarker to predict pathological grade and tumor recurrence in patients with glioma.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Authors: Kann BH, Park HS, Johnson SB, Chiang VL, Yu JB Abstract Background: Management of brain metastases typically includes radiotherapy (RT) with conventional fractionation and/or stereotactic radiosurgery (SRS). However, optimal indications and practice patterns for SRS remain unclear. We sought to evaluate national practice patterns for patients with metastatic disease receiving brain RT. Methods: We queried the National Cancer Data Base (NCDB) for patients diagnosed with metastatic non-small cell lung cancer, breast cancer, colorectal cancer, or melanoma from 2004 to 2014 who received upfront brain RT. Patie...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
ConclusionsA large proportion of family caregivers, including those experiencing depression and anxiety symptoms and who were underprepared, are not using formal support services but have a strong interest in services. Strategies to increase service use may include targeting distressed caregivers early in their caregiving experience.
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: PAPER Source Type: research
We present a case of non–small cell lung cancer with myocardial and pericardial metastases obscured by physiologic 18F-FDG cardiac uptake but detected with the investigational PET radiotracer (4S)-4-(3-18F-fluoropropyl)-L-glutamate (18F-FSPG), which targets a pathway associated with glutathione biosynthesis. This case demonstrates the added value of 18F-FSPG PET/CT imaging.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
ConclusionsChoroidal metastasis of renal cancer is a rare situation that must be actively sought in order to arrive at a suitable therapeutic approach.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
The molecular pathogenesis of squamous lung cancer is poorly understood – addressing this is a critical first step in improving early detection and treatment of this devastating disease. SOX2 amplification and overexpression is one of the most frequent genetic alterations in SQC (up to 90%). Although, it has been shown that deregulated SOX2 is an early and consistent event in squamous carcinogenesis, little is known about its downstream effects in early disease. We used a novel organotypic model of bronchial dysplasia to interrogate downstream effectors of SOX2 deregulation.In the novel organotypic culture system, SO...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Receptor for the scatter factor HGF MET is a key player in invasive growth, a genetic program which is implicated in the metastatic process. MET mutations affecting brain secondary lesions from NSCLC are significantly associated to radioresistance and poor outcome [[i]]. All the mutations found, affected either the SEMA domain of the receptor or its tyrosine kinase (TK) domain. We here focused on the nucleotide changes identified, namely E168D (SEMA), and V1312I (TK) mutations. Their oncogenic potential was investigated by reproducing the mutations in cDNAs and expressing the mutated MET proteins in T47D cells, as already ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Our Previous studies showed that CAP1 was associated with advanced TNM stage and poor prognosis of lung cancer patients, particularly at the Brain metastatic stage. In addition, Overexpression of CAP1 promotes the lung cancer cell proliferation, metastasis and migration in vitro and in vivo. The present study is carried out to evaluate the biological functions of CAP1 in lung cancer. We mapped phosphorylation sites on CAP1 and found S307/S309 to be regulatory sites and further identified GSK3 as a kinase phosphorylating S307/S309. we analyzed the cell apoptosis, proliferation by cell viability, MTT, ROS and flow cytometry ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
CONCLUSION: A substantial proportion of patients diagnosed with lung cancer show impairments in their capacity to make a medical decision. Assessment of cognitive impairment and frailty may provide appropriate decision-making frameworks to act in the best interest of patients. IMPLICATIONS FOR PRACTICE: Decision-making capacity is the cornerstone of clinical practice. A substantial proportion of patients with cancer show impairments in their capacity to make a medical decision. Assessment of cognitive impairment and frailty may provide appropriate decision-making frameworks to act in the best interest of patients. ...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
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