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Brain metastasis as initial presentation of lung cancer - Impact of prognostic factors on patient survival

Background: Brain metastasis (BM) in patients with cancer is a predictor of poor prognosis and is present at initial diagnosis in 15-30% of lung cancer patients.Methods: A retrospective analysis for a period of 27 years (1989-2016) identified patients with confirmed diagnosis of lung cancer and BM at presentation.Results: 192 patients were included, 98 (51%) had brain as the only site of metastatic disease. The mean age was 62.4±11.1 years and 163 (84.9%) were male patients. Thirty (31.3%) patients had solitary metastasis and 132 (68.8%) multiple metastasis. Therapeutic modalities for BM were: whole-brain radiation therapy (132, 68.8%), radiotherapy plus surgery (8, 4.2%), surgery (7, 3.6%), radiosurgery (1, 0.5%) and no treatment (44, 22.9%). Median survival was 3.7 months.Sixty-two (32.2%) patients received palliative chemotherapy and 118 (61.5%) best supportive care. Median survival in patients who received chemotherapy was 4.7 vs. 2 months in patients who didn’t receive (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research

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