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OPCs abate the prometastatic potential elicited by irradiation in lung cancer

This study investigated the advantages of OPCs in RT-elicited lung cancer metastasis. A549-bearing nude mice were administered with OPCs and/or RT treatment. The results indicated that OPCs markedly enhanced the radioresponses such as decreasing tumor’s volume and weight, with a significant reduction of MMP-2/-9 in A549-bearing xenografts (P
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research

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The erudite letter from the ASTRO Evidence-Based Guideline Committee for Stereotactic Body Radiation Therapy (SBRT) for Early-Stage Non –Small Cell Lung Cancer (ASTRO Group)1 carries a title that all clinicians managing lung cancer could easily agree on. Conversely, the style of the letter is typical of a diplomatic effort that may not to stand the test of time because of the underlying biases of both radiation oncologists and tho racic surgeons.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Thoracic: Lung cancer: Letter to the editor Source Type: research
In the closing remarks of an editorial recently published in the Journal, Schaheen and D'Cunha1 highlight the challenge for thoracic surgeons to adequately compare the efficacy of surgical resection and stereotactic body radiation  therapy (SBRT) for patients with operable stage I non–small cell lung cancer (NSCLC).1 We agree with their comments that “our patients aren't fully able to dissect the literature and the nuances of the trials”1 that have been published in the peer-reviewed literature and then recycled in the lay media with sensationalized headlines.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Thoracic: Lung cancer: Letter to the editor Source Type: research
ConclusionsTo the best of our knowledge, this is the first report about a gastric perforation after stereotactic body radiotherapy for lung tumors and it warns of serious complication of stereotactic body radiotherapy in not only centrally located but also peripherally located tumors like in this case.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Background: Brain metastasis (BM) in patients with cancer is a predictor of poor prognosis and is present at initial diagnosis in 15-30% of lung cancer patients.Methods: A retrospective analysis for a period of 27 years (1989-2016) identified patients with confirmed diagnosis of lung cancer and BM at presentation.Results: 192 patients were included, 98 (51%) had brain as the only site of metastatic disease. The mean age was 62.4±11.1 years and 163 (84.9%) were male patients. Thirty (31.3%) patients had solitary metastasis and 132 (68.8%) multiple metastasis. Therapeutic modalities for BM were: whole-brain radiation ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Conclusion: The LQ-L(Dt-mt) model is able to fit wide variety of cell survival data over a very wide dose range, and retains the strength of the LQ model in the low-dose range.
Source: Journal of Medical Physics - Category: Physics Authors: Source Type: research
AbstractIntroductionPercutaneous image-guided ablation is an emerging minimally invasive therapy for patients with metastatic bone disease for whom radiation therapy is ineffective or contraindicated. The purpose of this study was to examine the safety and efficacy of percutaneous ablation in achieving pain palliation and local tumor control of osseous metastases from non-small cell lung cancer (NSCLC).MethodsA retrospective review was performed of 76 musculoskeletal metastases in 45 patients treated with percutaneous ablation. 63% (48/76) were treated with radiofrequency ablation (RFA), 35% (27/76) with cryoablation, and ...
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
Authors: Yang RF, Yu B, Zhang RQ, Wang XH, Li C, Wang P, Zhang Y, Han B, Gao XX, Zhang L, Jiang ZM Abstract Non-small-cell lung cancer (NSCLC) patients who experience brain metastases are usually associated with poor prognostic outcomes. This retrospective study proposed to assess whether bevacizumab or gefitinib can be used to improve the effectiveness of whole brain radiotherapy (WBRT) in managing patients with brain metastases. A total of 218 NSCLC patients with multiple brain metastases were retrospectively included in this study and were randomly allocated to bevacizumab-gefitinib-WBRT group (n=76), gefitinib-...
Source: Brazilian Journal of Medical and Biological Research - Category: Research Tags: Braz J Med Biol Res Source Type: research
This article reviews current patterns of metastatic disease and the increasingly nuanced landscape of evolving therapies, their complications, and their impact on quality of survival. Recent Findings: Targeted therapies with tyrosine kinase inhibitors and immune checkpoint inhibitors and cytotoxic therapies directed at disease-specific chemosensitivity patterns have dramatically improved the prognosis of non–small cell lung cancer, melanoma, and breast cancer, but have led to some novel complications and altered recurrence patterns. Clinical trials suggest the superiority of hippocampal-avoidance radiation fields an...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: Review Articles Source Type: research
CONCLUSIONS: Between 2000 and 2010, stage I NSCLC patients were more likely to receive definitive treatment with either surgery or RT, leading to a decline in the number of untreated patients. Survival also improved substantially for stage I NSCLC patients, with the largest survival improvements observed in patients undergoing definitive RT. PMID: 29106887 [PubMed - indexed for MEDLINE]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
CONCLUSION: Our initial results show that SBRT is well tolerated with good local control. Although the PTV volume and irradiated normal lung volume was higher in this group compared to ABC group, this did not translate to any added clinical toxicity.
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
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