Role of lysyl oxidases in pathogenesis of pulmonary emphysema

Conclusions: We think that reductions of HIF-1α levels in PE led to decreases in protein levels of activated LOX, LOXL1 and LOXL2, and abnormalities in elastic fiber biology. In emphysematous areas, HIF-1α activation induced by decreased COMMD1 protein can contribute to the generation of disease pathogenesis. Approaches made to increase activated LOXs and COMMD1 can be effective for the regression of PE.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Mechanisms of Lung Injury and Repair Source Type: research

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Publication date: December 2019Source: Protein Expression and Purification, Volume 164Author(s): Elisabeth Graeber, Volodymyr M. KorkhovAbstractThe translocator protein TSPO is in an important diagnostic and therapeutic target in a range of pathologies, including neuroinflammation and cancer. Despite the availability of several structures of TSPO homologues, our understanding of the molecular determinants that govern high-affinity interactions of TSPO with its ligands is incomplete. Here, in order to decipher the key structural elements of TSPO responsible for interactions with its ligands, we designed a panel of chimeric ...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Publication date: Available online 20 July 2019Source: Biochemical Engineering JournalAuthor(s): V.M. Ortiz-Martínez, K. Touati, M.J. Salar-García, F.J. Hernández-Fernández, A.P. de los RíosAbstractMicrobial fuel cell (MFC) technology has attracted growing interest in the past decade for simultaneous bioenergy production and wastewater treatment. These devices require cost-effective cathode catalysts for the oxygen reduction reaction towards their practical implementation. The application of MFC technology for the specific treatment of industrial wastewater, which usually presents persist...
Source: Biochemical Engineering Journal - Category: Biochemistry Source Type: research
Source: ClinicoEconomics and Outcomes Research - Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
young female, known to have a metastatic breast cancer, since 5 years. In 2017, she developed secondary lesions in the brain with positive CSF. She receives 30Gy/10 fr whole brain radiation, with intra-thecal chemotherapy. A month ago, she developed gait disturbances with blurred speech an hemifacial paresia. Brain MRI showed a solitary secondary lesion, 1.5 cm involving the left middle cerebral peduncle with extensive edema. No signs of meningeal disease. Pet CT : NED outside the brain... SRS for BS lesion: what dose?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
Publication date: Available online 25 June 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Paolo A. Ascierto, Carlo Bifulco, Giuseppe Palmieri, Solange Peters, Nikoletta SidiropoulosAn enduring goal of personalized medicine in cancer is the ability to identify patients who are likely to respond to specific therapies. Our increasing understanding of the biology and molecular signatures of individual tumor types has facilitated the identification of predictive biomarkers and has led to an increasing number of diagnostic tests to be performed, often as serial and distinct assays on limited tumor specimens. The biom...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
CONCLUSION: The management of HCC in clinical practice frequently deviates from the BCLC recommendations. Most of the curative therapy options, which have well-defined selection criteria, were allocated according to the recommendations, while the majority of the palliative therapy options were assigned to patients with tumor stages not aligned with the recommendations. The only parameter which is subjective in the algorithm, the performance status, is also the least respected. PMID: 31320173 [PubMed]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Conclusions: Alterations to RV structure may represent a mechanism by which long-term PM10–2.5 exposure increases risks for adverse respiratory and cardiovascular outcomes, especially among certain susceptible populations. https://doi.org/10.1289/EHP658 Received: 14 June 2016 Revised: 24 February 2017 Accepted: 16 March 2017 Published: 27 July 2017 Address correspondence to S. D. Adar, University of Michigan School of Public Health, 1415 Washington Heights, SPH II-5539, Ann Arbor, MI 48109 USA. Telephone: (734) 615-9207; Email: sadar@umich.edu Supplemental Material is available online (https://doi.org/10.1289/E...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
To examine the airways in a minimally invasive fashion, bronchoscopy is the most used technique worldwide. Although the first bronchoscopy was a therapeutic one for the removal of a foreign body, until the 1970s the technique was more or less for diagnostic indications [1]. However, in recent years, bronchoscopy has experienced rapid development. More and more interventional techniques have been introduced, offering new options for patients [2]. In the early 2000s, endobronchial ultrasound-guided transbronchial needle aspiration was established, and cryoprobes are nowadays the preferred option for establishing the diagnosi...
Source: European Respiratory Review - Category: Respiratory Medicine Authors: Tags: Pulmonary pharmacology and therapeutics, Respiratory clinical practice Editorial Source Type: research
Over the last half century, technology has made possible the probing of the solar system and galaxy beyond. People can instantly correspond with anyone in the world. We can see —in real time—events and phenomena heretofore only reported by second and third hand accounts. Yet with all of the distance breached by modern devices, we are also able to know in detail the goings on inside our own bodies. With the advent of computed tomography (CT) imaging, known familiarly as “CAT scans,” doctors and their patients now get a bird’s eye view of internal organs. This scientific know-how goes beyond sim...
Source: ePharma Summit - Category: Pharmaceuticals Tags: Anatomy CT Scan Lungs Medical Devices Source Type: blogs
Hippocrates may well have appreciated the significance of the presence of emphysema, but it was not until the 17th century that Bonet1 described the larger lungs of those with emphysema, to which he attributed their breathlessness. In 1821, Laennec connected emphysema to ageing, when he ascribed a subtly different definition to emphysema, describing it as "a breakdown of tissue in the parenchyma of the lungs as opposed to air trapped in the alveoli due to obstruction as occurs in asthma and chronic bronchitis" essentially considering emphysema to be an ‘independent finding’ to obstructive lung disease...
Source: Thorax - Category: Respiratory Medicine Authors: Tags: Editorial Source Type: research
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