An observational study of the severity of respiratory depression (RDP) in opioid dependent patients (ODP)

Conclusions: ODP exhibited significant RDP in everyday life. Further studies are required to determine the association between RDP and overdose risk.ODPHCpBMI, kg/m231(27-32)27(24-27)<0.05FEV1%pred96.2(84-96.6)101(94.3-112.9)FVC%pred100(88-107.4)104.5(95-110)FEV1FVC%76.8(75-78.4)73.6(71-82.5)Baseline SpO2%9696pO2,kPa10.6(10.3-11.3)N/MpCO2, kPa5.2(5-5.5)N/MHCO3–, mmol/L24.4(24.2-24.3)N/MpH7.4N/MPrevalence of RDP indicesSpO2<90%>10s2/60/6=0.015ETCO2 per breath>6.5kPa4/61/6TcCO2 overall mean>6.5kPa3/60/6Respiratory Pauses>10s4/60/6Data as Median (IQR); N/M=not measured.

Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Tas, B., Cho, P. S. P., Lozano Garcia, M., Rafferty, G. F., Kelleher, M., Moxham, J., Strang, J., Jolley, C. J. Tags: Clinical Problems Others Source Type: research