The evaluation of serum biomarkers in patients with sarcoidosis: Can visfatin be a new biomarker for sarcoidosis?

There is no known biomarker for follow-up of patients with sarcoidosis. Visfatin is a proinflammatory adipokine which has been studied for several inflammatory diseases such as diabetes mellitus, obesity and metabolic syndrome. Our aim was to evaluate visfatin together with inflammatory biomarkers like serum ACE, sedimentation and CRP.59 patients with sarcoidosis were included in our study. Serum concentrations of visfatin were analyzed by ELISA. Patients were divided into those with and without parenchymal involvement. Serum ACE levels and ESR were significantly higher in patients with pulmonary involvement. There was no association between CRP levels, serum visfatin concentration and parenchymal involvement.We think visfatin is not a useful biomarker for diagnosing and monitoring sarcoidosis. Comparison of sarcoidosis patients with/without parenchymal involvementWith parenchymal involvementWithout parenchymal involvementpCRP (mg/l)7.62±8.284.81 ±4.110.282Sedimentation (mm/hr)27.08 ±17.6719.81 ±7.690.043Serum ACE level (U/L)75.91 ± 54.8439.95 ± 23.920.002Serum visfatin level (ng/ml)30 ± 15.5128.90 ± 17.640.826
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Diffuse Parenchymal Lung Disease Source Type: research

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CONCLUSION: WFRP is fast and effective in screening for diabetic retinopathy. The severity grade of the disease was similar to the gold standard of FRP in most cases. WFRP could thus be used in mass screening for diabetic retinopathy. PMID: 31104875 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Publication date: Available online 20 May 2019Source: Journal of Geriatric OncologyAuthor(s): Elizabeth J. Siembida, Erin E. Kent, Keith M. Bellizzi, Ashley Wilder SmithAbstractObjectivesPhysical activity (PA) promotes physical functioning and health-related quality of life in older survivors of cancer. Using a population-based sample of Medicare Advantage beneficiaries, we aimed to characterize the survivors who reported discussing PA with their healthcare provider.Materials and MethodsData from the Surveillance, Epidemiology, and End Results (SEER) cancer registries was linked with the 2008–2014 Medicare Health Out...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
A Kansas City physician and diabetes researcher has been named chief medical officer for California-based Glooko. Dr. Mark Clements, has served on Glooko's medical advisory board since the diabetes data management company was formed in 2015. Glooko's software integrates with patient electronic health records and synchronizes data from more than 190 diabetes devices and fitness and activity trackers. It uses t his information to deliver patient data, including glucose levels, blood pressure and insulin…
Source: Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
A recentNew York Timesarticle reports that today ’s Democratic primary in Philadelphia partially represents a referendum on the city’s soda tax, even though it is not on the ballot. Incumbent Mayor Jim Kenney, the engineer of the 1.5 cents per ounce tax on sugary and artificially sweetened beverages which took effect in 2017, is facing two Dem ocratic challengers who both support repealing the controversial tax.Since its inception, the tax has faced vigorous opposition from a coalition of the beverage industry, grocery store owners, and Teamsters, as well as citizens and politicians who worried that it would un...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
As technology has improved, it has become easier for diabetes patients to monitor their blood sugar levels. The number of businesses offering monitoring devices is competitive, however.
Source: Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
ConclusionsReLTX is a reasonable option for a selected group of patients. Ideally a number of well-established risk factors is avoided and the ReLTx performed more than one year after the PLTx.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
In conclusion, Jun, Ptgs2, Fn1, Cdk2, Fos, Hspa5, Hsp90b1, Hyou1, RHOB, CFH and KLF15 may be potential therapeutic targets for mesangial cells associated with DN, which may provide insight into DN treatment strategies. PMID: 31105790 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Yu Y, Cai J, Song Z, Wang J, Wu L Abstract The association between Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) determined in different cohorts from different countries is currently inconclusive. In the majority of previous studies, H. pylori infection was diagnosed based on the presence of H. pylori IgG antibody in the serum. However, to the best of our knowledge, only few studies have investigated the association between H. pylori infection and MetS using the urea breath test (UBT) as a diagnostic tool. The present study was performed with the aim of providing a detailed analys...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Samy AL, Kamaruzzaman SB, Krishnaswamy S, Low WY Abstract OBJECTIVES: To study the prevalence of Mild Cognitive Impairment (MCI) among older people attending primary care clinics and its predictors of QOL. METHODS: A cross-sectional study was conducted at two primary care clinics in Kuala Lumpur, Malaysia, recruiting 271 participants by utilizing the universal sampling method. Every patient who attended both the clinics during the study period and met the inclusion and exclusion criteria were approached and briefed about the study. Patients who gave consent were recruited as study participants. Informa...
Source: Clinical Gerontologist - Category: Geriatrics Tags: Clin Gerontol Source Type: research
CONCLUSIONS: In a "real-life" general population, the association between vitamin D deficiency and unexplained elevated ALT is specific for non-obese men. The clinical significance of vitamin D for human NAFLD should be further elucidated with attention for a modifying effect of gender and adiposity. PMID: 31103458 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
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