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Silicosis In Denim Sandblasters: Aftershocks Of An Epidemic

Background: We add data from a single center reviewing risk factors for silicosis together with survival analysis and a perspective for lung transplantation.Methods: We reviewed medical records of denim sandblasters who were admitted to our center between January 2006 and December 2011. Several personal and occupational features, together with functional and radiologic data, were collected.Results: Of 219 denim sandblasters, 107 (48.9%) had been diagnosed as silicosis. Duration of exposure was an independent risk factor for development of silicosis. Seven (3.2%) patients died. FEV1
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Occupational and Environmental Health Source Type: research

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The heart failure (HF) epidemic continues to grow, propelled by an aging population and life-prolonging medical advances. To improve patient-centered outcomes and reduce costs, providers must accurately identify patients at highest risk for rehospitalization and death. Most prognostic models in HF focus on comorbid conditions, physical, hemodynamic, and biomarker markers of HF severity.1
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
The heart failure (HF) epidemic continues to grow, propelled by an aging population and life-prolonging medical advances. To improve patient-centered outcomes and reduce costs, providers must accurately identify patients at highest risk for rehospitalization and death. Most prognostic models in HF focus on co-morbid conditions and the physical, hemodynamic and biomarker measures of HF severity.1
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research Correspondence Source Type: research
We are currently facing an epidemic of patients surviving end stage heart failure. Although over 20,000 patients may benefit from heart transplantation per year, only 3,000 will receive a new heart, with a waitlist mortality of 10.7 deaths per 100,000 wait-list years.1 Due to this growing disparity, we are no longer able to limit acceptance to the “ideal” organ. As such, there has been increased interest in identifying donor risk factors that, while not ideal, still result in acceptable recipient outcomes.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
A "Mini-Epidemic" of anti-glomerular basement membrane disease: Clinical and epidemiological study. Saudi J Kidney Dis Transpl. 2017 Sep-Oct;28(5):1057-1063 Authors: Lingaraj U, Mallappa SS, Neminah RE, Mohan SM, Venkatesh L, Gurusiddaiah SC, Rachaiah NM Abstract Acute glomerulonephritis due to anti-glomerular basement membrane (anti-GBM) antibody disease is rare, estimated to occur in fewer than one case per million population and accounts for less than 20% of rapidly progressive glomerulonephritis. The prevalence among patients evaluated for potential glomerular disease is lower. It accoun...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
Conclusion: We propose that when CFA arrives at the airway, it rapidly adsorbs AMPs and creates negative complexes, thereby decreasing the functional amount of AMPs capable of killing pathogens. These results provide a novel translational insight into an early mechanism for how ambient PM increases the susceptibility of the airways to bacterial infection. https://doi.org/10.1289/EHP876 Received: 27 July 2016 Revised: 30 December 2016 Accepted: 19 January 2017 Published: 05 July 2017 Address correspondence to A. P. Comellas, 6312 Pappajohn Biomedical Discovery Building. Newton Road, Iowa City, Iowa, USA, 52242; Teleph...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
BY JOHN IRVINE We asked THCB’s editors and bloggers for their reactions to Friday’s news. Here are their reactions. DANIEL STONE, MD The late UCLA Professor Richard Brown, once commented that the Clinton healthcare initiative failed because the status quo was everyone’s second choice. Some of that logic applies to today’s failure to vote on the AHCA. Additionally, no one ever lost money betting against the rollback of an established entitlement program. The Republicans opponents of the ACA have not yet faced the fact that the reason coverage is so expensive is because the care is so expensive. You ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized John Irvine Source Type: blogs
Rationale Epidemic Pseudomonas aeruginosa (PA) plays an important role in cystic fibrosis (CF) lung disease. A novel strain, the ‘Prairie Epidemic Strain’ (PES), has been identified in up to 30% of patients in Prairie-based Canadian CF centres. Objective To determine the incidence, prevalence and long-term clinical impact of PES infection. Methods A cohort of adults with CF was followed from 1980 to 2014 where bacteria isolated from clinical encounters were prospectively collected. Strain typing was performed using pulse-field gel electrophoresis and multilocus sequence typing. Patients were divided into one ...
Source: Thorax - Category: Respiratory Medicine Authors: Tags: Epidemiologic studies, Cystic fibrosis, Cardiothoracic surgery, Transplantation Source Type: research
Hepatocellular cancer (HCC) is increasing dramatically in incidence in Europe and the United States due mainly to the hepatitis C epidemic and, to a lesser extent, increased body mass index of the population. In the fairly recent past, HCC was largely considered as untreatable due to detection mainly at late stages and lack of effective drugs for treatment. Several advances have led to changes in the prognosis of HCC. Screening of high-risk populations has allowed for earlier detection in some studies. If found at an early stage, liver transplantation not only cures the usual underlying cirrhosis but has cure rates for HCC...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
There’s something you should know about chronic kidney disease. Most doctors will tell you there is no alternative treatments for kidney problems besides costly dialysis or a transplant to deal with impaired renal function. What Is Kidney Failure? Kidney dialysis is a treatment that uses a special machine to filter harmful wastes, salt and excess from your blood. But there is another option. It’s called stem cell biotherapy, and it offers new hope to those with this life-threatening disease. You may think your kidneys are just fine and you have nothing to worry about. But consider this… What Causes Kidn...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health Source Type: news
by Rosa van Mansfeld, Angelica de Vrankrijker, Roland Brimicombe, Harry Heijerman, Ferdinand Teding van Berkhout, Cristian Spitoni, Sanne Grave, Cornelis van der Ent, Tom Wolfs, Rob Willems, Marc Bonten Introduction Segregation of patients with cystic fibrosis (CF) was implemented to prevent chronic infection with epidemic Pseudomonas aeruginosa strains with presumed detrimental clinical effects, but its effectiveness has not been carefully evaluated. Methods The effect of strict segregation on the incidence of P. aeruginosa infection in CF patients was investigated through longitudinal protocolized follow-up of respirator...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
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