Small risk of breast cancer seen with hormone contraceptives

Modern low-dose birth control pills, available since the 1990s, have fewer side effects than the earliest oral contraceptives
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news

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Condition:   Pathologic Residual Cancer Cells Interventions:   Drug: Capecitabine, Oral, 500 Mg;   Drug: Vinorelbine Tartrate Oral Sponsor:   Zhiyong Yu Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsSatisfaction with a simplifiedBRCA1/2 testing procedure was very high. Written pre-test information has now replaced in-person pre-test counseling for breast cancer patients in our health care region.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionOur study provides real-world data on the use of oral weekly vinorelbine, which proves an effective and well-tolerated regimen for MBC patients previously treated with taxanes or anthracyclines. Patients with HER2-positive disease could also benefit from this treatment in combination with trastuzumab.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 5 October 2018Source: Inorganic Chemistry CommunicationsAuthor(s): D. Shiva Shankar, Aveli Rambabu, Narendrula Vamsikrishna, Nirmala Ganji, Sreenu Daravath, ShivarajAbstractHerein, we have reported three novel mononuclear copper (II) complexes 1. [Cu(L1)2], 2. [Cu(L2)2] and 3 [Cu(L3)2] where, L1H = (2-(4-methylbenzylimino)methyl)-4-nitrophenol, C15H14N2O3)), L2H = (2-(4-methylbenzylimino)methyl)-4-chlorophenol, C15H14ClNO)) and L3H = (2-(4-methylbenzylimino)methyl)-4,6-dichlorophenol, C15H13Cl2NO)) have been characterized by several physicochemical techniques. Having a base of...
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
Publication date: November 2018Source: Pharmacological Research, Volume 137Author(s): Wenlong Li, Rolf W. Sparidans, Yaogeng Wang, Maria C. Lebre, Jos H. Beijnen, Alfred H. SchinkelAbstractBrigatinib is an FDA-approved oral anaplastic lymphoma kinase (ALK) inhibitor for treatment of metastatic non-small cell lung cancer (NSCLC). Using genetically modified mouse models, we investigated the roles of the multidrug efflux transporters ABCB1 and ABCG2, and the multispecific drug-metabolizing enzyme CYP3 A in plasma pharmacokinetics and tissue distribution of brigatinib. In vitro, brigatinib was exceptionally well transpo...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: 1 December 2018Source: International Journal of Pharmaceutics, Volume 552, Issues 1–2Author(s): Ruiling Liu, Yue Jiang, Xu Hu, Jilian Wu, Wei Jiang, Guoxia Jin, Yuxia LuanAbstractCytarabine (Ara-C) has become cornerstones for the treatment of hatmatological malignancies for several decades; however, it still faces serious challenges in clinical applications due to its side effects such as hand foot syndrome (HFS) and stomatitis. Therefore, considerable researchers have devoted to looking for the new derivative with desirable activity and low toxicity. A new prodrug based on the conjugation of cytara...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Abstract Curcumin diglutaric acid (CG) is a prodrug of curcumin that shows better solubility and antinociceptive activity compared to curcumin. To improve its properties further, CG was encapsulated into polysaccharide-based nanoparticles in this study. A chitosan/alginate nanoparticulate system was chosen for encapsulation of CG due to its biocompatibility, biodegradability, non-toxicity, mucoadhisiveness and good film formation. CG-loaded chitosan/alginate nanoparticles were prepared by o/w emulsification and ionotropic gelification, with the conditions optimized using response surface methodology. A chitosan/al...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
Ines Velez, DDS, MS, recently succumbed to breast cancer after a decades-old battle with the disease. Her bravery and dignity in the face of this disease was inspiring to those of us who knew and loved her. She reported to work until the week before her passing. Her husband Guillermo stated that “she went out on her own terms, surrounded by me, her children, and her grandchildren. It was beautiful.”
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Source: Vascular Health and Risk Management - Category: Cardiology Tags: Breast Cancer: Targets and Therapy Source Type: research
Abstract OBJECTIVE: The established link between estrogen and breast cancer occurs via both estrogen receptor (ER)-mediated and non ER-mediated mechanisms. The term genotoxic estrogens describes mutagenic metabolites, including estrogen catechols and quinones, which have been linked to breast carcinogenesis in post-menopausal women. We aimed to assess if the route of administration of 17β estradiol (E2 ) affects the accumulation of genotoxic estrogen metabolites in a model of ovarian failure in young girls with Turner Syndrome. METHODS: Stored plasma samples obtained at 0 and 12 months were used from 40 ...
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: Clin Endocrinol (Oxf) Source Type: research
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