Log in to search using one of your social media accounts:

 

Patterns of care and survival outcomes after treatment for uveal melanoma in the post-coms era (2004-2013): a surveillance, epidemiology, and end results analysis.

Patterns of care and survival outcomes after treatment for uveal melanoma in the post-coms era (2004-2013): a surveillance, epidemiology, and end results analysis. J Contemp Brachytherapy. 2017 Oct;9(5):453-465 Authors: Rao YJ, Sein J, Badiyan S, Schwarz JK, DeWees T, Grigsby P, Rao PK Abstract Purpose: The Collaborative Ocular Melanoma Study (COMS) established modern treatment recommendations for uveal melanoma. We aim to evaluate patterns of care and survival outcomes in the time after COMS. Material and methods: The retrospective study population includes 2,611 patients in the SEER database treated for uveal melanoma between 2004-2013. Patients stage were T1-4N0M0. Data analyzed included age, clinical stage, tumor size, race, and treatment. Treatments included enucleation (EN) and globe preserving therapy (GPT), which consisted of limited surgical resection or ablation (LSRA), external beam radiation (EBRT), or brachytherapy (BT). Patients treated with radiation may receive radiation therapy alone (RTA) or radiation therapy and supplemental laser therapy (RT+SLT). We evaluated disease specific survival (DSS) and overall survival (OS) using log-rank statistics, and Cox univariate and multivariate analysis. Results: The median follow-up was 44 months. Treatment strategy was EN in 538 (20.6%) patients, LSRA in 80 (3.1%), EBRT in 609 (23.3%), and BT in 1,384 (53.0%). 1,876 patients received RTA and 117 received RT+SLT. Enucleation was associated wi...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Related Links:

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Iris melanoma comprises 4% to 10% of all UMs and has a lower mortality rate. The genetic changes in iris melanoma are not as well characterized as ciliary body or choroidal melanoma. The aim of this study was to gain more insight into the genetic background of iris melanoma and iris nevi.
Source: Ophthalmology - Category: Opthalmology Authors: Source Type: research
Conclusions: New multiple enhancing solid liver lesions should raise suspicion of uveal melanoma liver metastases. Discussion of challenging cases with the radiologist may be beneficial, as pertinent information such as size, location, and molecular prognostication status of the primary tumor can guide radiological interpretation of hepatic lesions.Ocul Oncol Pathol 2018;4:254-260
Source: Ocular Oncology and Pathology - Category: Opthalmology Source Type: research
Valsecchi y otros (p. 210) evaluaron el uso de sunitinib, como terapia adyuvante, en un grupo de pacientes con melanoma uveal con alto riesgo de desarrollar met ástasis distante. Hicieron un estudio de cohorte retrospectivo en pacientes de melanoma uveal diagnosticados entre febrero de 2007 y enero de 2013 y seleccionados de la base de datos del Servicio de Oncología Ocular del Wills Eye Hospital. Los investigadores compararon la sobrevida global de 54 pa cientes que recibieron sunitinib como adyuvante administrado durante 6 meses a 74 pacientes en el grupo de control, con los mismos factores de riesgo.
Source: Ophthalmology - Category: Opthalmology Authors: Tags: This issue at a glance Source Type: research
Valsecchi et  al (p. 210) evaluated the use of sunitinib as adjuvant therapy in a group of uveal melanoma patients with a high risk of developing distant metastases. They conducted a retrospective cohort study on uveal melanoma patients diagnosed from January 2007 to January 2013 and selected from the database of the Ocular Oncology Service at Wills Eye Hospital. The researchers compared the overall survival of 54 patients who received adjuvant sunitinib for 6 months to 74 patients in the control group with the same risk factors.
Source: Ophthalmology - Category: Opthalmology Authors: Tags: This issue at a glance Source Type: research
No abstract available
Source: Cornea - Category: Opthalmology Tags: Letters to the Editor Source Type: research
Ocular melanocytosis portends a higher risk of uveal melanoma. Multifocal uveal melanoma has been described previously and has been associated with ocular melanocytosis. Historically, histopathology has been used to differentiate tumors; however, molecular profiling now allows for better prognostication and determination of metastatic risk. The present case describes a patient with ocular melanocytosis who developed two sequential uveal melanomas in the same eye separated by 4 years. The uveal melanoma-specific gene expression profile (GEP) testing for the first tumor was class 1A and the second tumor was class 2. While th...
Source: Ocular Oncology and Pathology - Category: Opthalmology Source Type: research
A 82-year-old woman with histopathologically proven, locally advanced, multifocal, infiltrative basal cell carcinomas (BCCs) of the centro-facial area and the d écolleté was referred to the skin cancer unit, Medical University of Graz (Austria). She was not considered a candidate for surgery or radiotherapy, so she started treatment with the hedgehog (HH) inhibitor vismodegib (150 mg/day orally). Owing to increasing dysgeusia and muscle cramps, the dosag e of vismodegib was continuously reduced after the first 3 months to 150 mg every second day (month 4), to every third day (month 5) until twice/we...
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Letter to the Editor Source Type: research
In this study, we examined the expression of nestin in primary (PUM) and metastatic uveal melanoma (MUM) samples, and correlated the findings with histological, clinical and survival data. MethodsNestin expression was assessed by immunohistochemistry in 141 PUM and 26 MUM samples; 11 PUM cases were matched with their corresponding metastases. The percentage of tumour cells expressing nestin was scored by three independent observers. Statistical analysis of all data was performed with SPSS. ResultsNestin expression was identified in both the cytoplasm and membrane of UM cells. Increased expression of nestin in PUM samples w...
Source: Acta Ophthalmologica - Category: Opthalmology Authors: Tags: Original Article Source Type: research
ConclusionThis study provides evidence that a novel UM volume estimation method might offer a practical and cost‐efficient alternative to improve the prognostic value intrinsic to a tumour's size.
Source: Acta Ophthalmologica - Category: Opthalmology Authors: Tags: Original Article Source Type: research
This study evaluated outcomes of iris melanoma per the AJCC classification, eighth edition.
Source: Ophthalmology - Category: Opthalmology Authors: Tags: Original Article Source Type: research
More News: Brachytherapy | Databases & Libraries | Epidemiology | External Beam Therapy | Eye Cancers | Laser Surgery | Laser Therapy | Melanoma | Radiation Therapy | Skin Cancer | Statistics | Study | Uveal Melanoma