Independent assessment of source position for gynecological applicator in high-dose-rate brachytherapy.
Conclusions: In HDR brachytherapy, an effectiveness of independent source position assessment could be demonstrated. The 95% confidence limit was 2.1 mm for a tandem-ovoids applicator. PMID: 29204169 [PubMed]
(University of Virginia Health System) Offering brachytherapy for locally advanced cervical cancer ends up costing hospitals money, potentially explaining its declining use even though it's considered the most effective treatment.
The standard of care for locally advanced cervical cancer is the combination of chemotherapy, external beam radiation therapy (EBRT), and brachytherapy. The integration of magnetic resonance imaging –based planning and delivery for brachytherapy has resulted in local control rates of 80-90%, with a reduced risk of grade 3 morbidities (1). Despite these excellent results, a surprising number of patients with cervical cancer do not receive brachytherapy in favor of intensity modulated radiation therapy (IMRT) or stereotactic body radiation therapy boosts, resulting in inferior survival outcomes (2, 3).
To develop an anthropomorphic breast phantom for use in credentialing of permanent breast seed implant brachytherapy.
We present our findings with placing a rectal hydrogel spacer in patients following LDR brachytherapy, and we further assess the impact of this placement on dosimetry and acute rectal toxicity.
To determine the dosimetric impact of organ and implant motion/deformation in the context of adaptive planning in image-guided gynecologic brachytherapy using a 3-fraction transperineal approach.
Authors: Mudambi L, Miller R, Eapen GA Abstract This review comprehensively describes recent advances in the management of malignant central airway obstruction (CAO). Malignant CAO can be a dramatic and devastating manifestation of primary lung cancer or metastatic disease. A variety of diagnostic modalities are available to provide valuable information to plan a therapeutic intervention. Clinical heterogeneity in the presentation of malignant CAO provides opportunities to adapt and utilize endoscopic technology and tools in many ways. Mechanical debulking, thermal tools, cryotherapy and airway stents are methods a...
Re-irradiation in gynaecological malignancies has become an increasingly frequent consideration. This can be delivered in multiple settings, with the most common being a patient with a history of cervical cancer developing a new vaginal cancer or endometrial cancer with local recurrence after hysterectomy and adjuvant pelvic radiation. A systematic review of the literature has unearthed a handful of reports, most delivering brachytherapy, with a small number on both external beam radiotherapy and stereotactic ablative radiotherapy.
Abstract A 58-year-old man was referred for selective internal radiation therapy for locally advanced unresectable hepatocellular carcinoma. Intra-arterial particle perfusion scintigraphy was performed with SPECT/CT following intra-arterial injection of 99mTc macroaggregated albumin. Angiography demonstrated a hepatic falciform artery, a feeding artery of the ligamentum teres, whereas scintigraphy demonstrated tracer uptake in the mid–anterior abdominal wall. The hepatic falciform artery was subsequently embolized and the repeat angiogram confirmed successful occlusion. Subsequent post–selective internal radi...
The Xoft Axxent Electronic Brachytherapy System (Xoft, Inc., San Jose, CA) is a viable option for intraoperative radiation therapy (IORT) treatment of early-stage breast cancer. The low-energy (50-kVp) X-ray source simplifies shielding and increases relative biological effectiveness but increases dose distribution sensitivity to medium composition. Treatment planning systems typically assume homogenous water for brachytherapy dose calculations, including precalculated atlas plans for Xoft IORT. However, Xoft recommends saline for balloon applicator filling.
For older women with breast cancer, local therapy options may include lumpectomy plus whole breast irradiation (Lump+WBI), lumpectomy plus brachytherapy (Lump+Brachy), lumpectomy alone (Lump alone), mastectomy without radiation (Mast alone), and mastectomy plus radiation (Mast+RT). We surveyed a population-based cohort of older breast cancer survivors to assess the association of local therapy with long-term quality of life (QOL) outcomes.