Majority of leukaemia patients lack access to specialist nurse
Only around a third of patients with leukaemia have access to specialist nurses, according to leading blood cancer charity.
Abstract From stem cells, to the cancer stem cell hypothesis and intratumoral heterogeneity, the following introductory chapter on brain tumor stem cells explores the history of normal and cancerous stem cells, and their implication in the current model of brain tumor development. The origins of stem cells date back to the 1960s, when they were first described as cells capable of self-renewal, extensive proliferation, and differentiation. Since then, many advances have been made and adult stem cells are now known to be present in a very wide variety of tissues. Neural stem cells were subsequently discovered 30&nbs...
In conclusion, the Vγ9Vδ2 T cells activated by cancer cell lysate showed APC characteristics, and this may greatly increase interest in investigating their therapeutic potential in hematologic malignancies. Abbreviations: CML: chronic myeloid leukemia; APC: antigen-presenting cell; TCR: T cell receptor; MHC: major histocompatibility complex; N-BPs: nitrogen-containing bisphosphonates; IPP: isopentenyl pyrophosphate; PBMC: peripheral blood mononuclear cells; NKG2D: natural killer receptor group 2, member D; TRAIL: tumor necrosis factor-related apoptosis-inducing ligand. PMID: 30321079 [PubMed - as supplied by publisher]
(Oregon Health&Science University) After more than five years and 672 patient samples, an OHSU research team has published the largest cancer dataset of its kind for a form of leukemia. The study, 'Functional Genomic Landscape of Acute Myeloid Leukemia,' published today in Nature.
(Howard Hughes Medical Institute) Data on the molecular makeup and drug sensitivity of hundreds of patient samples could accelerate progress against the aggressive blood cancer acute myeloid leukemia.
Publication date: Available online 16 October 2018Source: Cancer GeneticsAuthor(s): Kathy Chun, Gail D. Wenger, Alka Chaubey, D.P. Dash, Rashmi Kanagal-Shamanna, Sibel Kanturci, Ravindra Kolhe, Daniel L. Van Dyke, Lu Wang, Daynna J. Wolff, Patricia M. MironAbstractThe prognostic role of cytogenetic analysis is well-established in B-cell chronic lymphocytic leukemia (CLL). Approximately 80% of patients have a cytogenetic aberration. Interphase FISH panels have been the gold standard for cytogenetic evaluation, but conventional cytogenetics allows detection of additional abnormalities, including translocations, complex karyo...
Contributors : Liangxian Cao ; Marla Weetall ; Christopher Trotta ; Katherine Cintron ; Jiyuan Ma ; Min J Kim ; Bansri Furia ; Charles Romfo ; Jason D Graci ; Wencheng Li ; Joshua Du ; Josephine Sheedy ; Jean Hedrick ; Nicole Risher ; Shirley Yeh ; Hongyan Qi ; Tamil Arasu ; Seongwoo Hwang ; William Lennox ; Ronald Kong ; Janet Petruska ; Young-Choon Moon ; John Babiak ; Thomas W Davis ; Allan Jacobson ; Neil G Almstead ; Art Branstrom ; Joseph M Colacino ; Stuart W PeltzSeries Type : Expression profiling by arrayOrganism : Homo sapiensPTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen a...
A Wilmot Cancer Institute study uncovers how a single gene could be at fault in acute myeloid leukemia (AML), one of the deadliest cancers. The breakthrough gives researchers renewed hope that a gene-targeted therapy could improve AML survival rates, which have not budged in recent years.
Pediatric Blood&Cancer, EarlyView.
Pediatric Blood&Cancer, EarlyView.
Cancer Science,Volume 0, Issue ja, -Not available-.