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Is This the Deal LivaNova has Been Waiting For?

LivaNova isn't one to waste time. Just two weeks ago the London-based company unveiled plans to divest its cardiac rhythm management business (CRM) to MicroPort for $190 million in cash, a move that would allow the company to shift more focus to its areas of strength, including neuromodulation. This week, the company said it has agreed to pay up to $225 million to acquire San Diego, CA-based ImThera Medical. ImThera develops neurostimulation technology for the treatment of obstructive sleep apnea (OSA). The company's implantable device is designed to stimulate multiple tongue muscles via the hypoglossal nerve, which opens the airway while a patient is sleeping. LivaNova has been an investor in ImThera since 2011. To acquire the remaining outstanding interests of ImThera, LivaNova has agreed to pay about $78 million up front, plus regulatory and sales-based milestone payments up to a total of roughly $225 million. The company expects the deal to close in early 2018 and be near-term accretive. "The ImThera device is highly aligned with our existing neuromodulation business, and we are extremely excited about the opportunity to optimize the technology and fold it into our universal platform," said LivaNova CEO Damien McDonald. He said that in the near term the company will focus on expanding ImThera's commercial presence in Europe, while advancing enrollment in an FDA pivotal trial for the OSA implant. “The OSA market is large a...
Source: MDDI - Category: Medical Devices Authors: Tags: Medical Device Business Source Type: news

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ConclusionsThis study adds to growing evidence that cardiovascular risk from TRT may be less than once feared. The increased risk of sleep apnea in men using TRT is noteworthy. The study strengths include the large number of healthy and young men exposed to TRT. Limitations include the retrospective study design inability to account for granular details of TRT use such as dosage, specific forms of TRT and serum testosterone levels pre‐ and post‐TRT.This article is protected by copyright. All rights reserved.
Source: BJU International - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Introduction: The association of Obstructive Sleep Apnea Syndrom (OSAS) with cardiovascular diseases as coronary heart disease (CVD), hypertension, stroke, arrhythmias, heart failure and metabolic disease as diabetes II is well documented. Results of correlations with different parameters of OSAS as Apnea-/Hypopnea-Index (AHI), Oxygen-Desaturation-Index (ODI), minimal Oxygen saturation (SaO2  min), mean Oxygensaturation (mean SaO2) or time with oxygen saturation below 90% (SaO2
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: Sleep Breathing Disorders Source Type: research
Introduction: Obstructive sleep apnea is a common chronic medical condition strongly linked with obesity. Obstructive sleep apnea has been associated with cardiovascular morbidity such as arterial hypertension, stroke and heart failure, but the majority of these studies were done in sleep laboratory populations of predominantly male subjects. We hypothesize that obstructive sleep apnea will be associated with arterial hypertension in both genders in the general population.
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: Sleep Breathing Disorders Source Type: research
Conclusions:Hypoxia induced by nightly cessation of breathing increases patients' risk of coronary artery disease, heart failure, stroke, and other conditions. As with many maladies detrimental to vascular health, obstructive sleep apnea affects the eye and ocular adnexa. This paper summarizes the current evidence implicating OSA in these ocular maladies and highlights their proposed mechanisms. The authors describe ocular pathology which sleep specialists may encounter. We encourage more aggressive attention to ocular symptoms in patients with sleep apnea to prevent vision-threatening complications. Further research shoul...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Abstract Emerging research highlights the complex interrelationships between sleep-disordered breathing and cardiovascular disease, presenting clinical and research opportunities as well as challenges. Patients presenting to cardiology clinics have a high prevalence of obstructive and central sleep apnea associated with Cheyne-Stokes respiration. Multiple mechanisms have been identified by which sleep disturbances adversely affect cardiovascular structure and function. Epidemiological research indicates that obstructive sleep apnea is associated with increases in the incidence and progression of coronary heart dis...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
Abstract BACKGROUND: Obstructive sleep apnea (OSA) during rapid eye movement (REM) sleep is a common disorder. Data on whether OSA that occurs predominantly during REM sleep is associated with health outcomes are limited. The present study examined the association between OSA during REM sleep and a composite cardiovascular endpoint in a community sample with and without prevalent cardiovascular disease. METHODOLOGY: Full montage home polysomnography was conducted as part of the Sleep Heart Health Study. The study cohort was followed for an average of 9.5 years during which cardiovascular events were assessed....
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
CONCLUSIONS: Our meta-analysis demonstrates that after cardiac surgery, MACCEs and newly documented POAF were 33.3% and 18.1% higher odds in OSA versus non-OSA patients, respectively.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. PMID: 29049073 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Authors: Lombardi C, Tobaldini E, Montano N, Losurdo A, Parati G Abstract There is increasing evidence of a relationship between Obstructive Sleep Apnea (OSA) and cardiovascular diseases. The strong association between OSA and arterial hypertension, in particular in patients with resistant hypertension and/or a non-dipping profile, has been extensively reported. The relationship between OSA and high blood pressure (BP) has been found independent from a number of confounders, but several factors may affect this relationship, including age and sex. It is thus important to better assess pathophysiologic and clinical i...
Source: Medicina del Lavoro - Category: Occupational Health Tags: Med Lav Source Type: research
CONCLUSIONS: Acoustic transference function of middle ear is similar in adults with and without OSA. Severe OSA is independently associated with cochlear function impairment in patients with no significant co-morbidities. PMID: 28681146 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
ConclusionsAcoustic transference function of middle ear is similar in adults with and without OSA. Severe OSA is independently associated with cochlear function impairment in patients with no significant co-morbidities.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
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