Is This the Deal LivaNova has Been Waiting For?

LivaNova isn't one to waste time. Just two weeks ago the London-based company unveiled plans to divest its cardiac rhythm management business (CRM) to MicroPort for $190 million in cash, a move that would allow the company to shift more focus to its areas of strength, including neuromodulation. This week, the company said it has agreed to pay up to $225 million to acquire San Diego, CA-based ImThera Medical. ImThera develops neurostimulation technology for the treatment of obstructive sleep apnea (OSA). The company's implantable device is designed to stimulate multiple tongue muscles via the hypoglossal nerve, which opens the airway while a patient is sleeping. LivaNova has been an investor in ImThera since 2011. To acquire the remaining outstanding interests of ImThera, LivaNova has agreed to pay about $78 million up front, plus regulatory and sales-based milestone payments up to a total of roughly $225 million. The company expects the deal to close in early 2018 and be near-term accretive. "The ImThera device is highly aligned with our existing neuromodulation business, and we are extremely excited about the opportunity to optimize the technology and fold it into our universal platform," said LivaNova CEO Damien McDonald. He said that in the near term the company will focus on expanding ImThera's commercial presence in Europe, while advancing enrollment in an FDA pivotal trial for the OSA implant. “The OSA market is large a...
Source: MDDI - Category: Medical Devices Authors: Tags: Medical Device Business Source Type: news

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Authors: Al-Khadra Y, Darmoch F, Alkhatib M, Baibars M, Alraies MC Abstract Background: Obstructive sleep apnea (OSA) is a known risk factor for atrial fibrillation (AF) that is principally driven by left atrial enlargement. The impact of hypoventilation caused by obesity-induced hypoventilation syndrome (OHS) on left atrial diameter has not been examined. We investigated the association between OHS and left atrial diameter in obese patients. Methods: We performed a retrospective review of 210 consecutive medical records of patients diagnosed as obese (body mass index [BMI]>30 kg/m2) and as having OHS and OS...
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
Obstructive sleep apnea (OSA) is characterized by repetitive pharyngeal collapse during sleep. The result is fragmented sleep, excessive daytime sleepiness; hypoxia and hypercarbia; decreased vigilance, motor coordination, and executive function; depression; and decreased quality of life. If untreated, the patient can develop hypertension, arrhythmias, congestive heart failure, a higher risk for cardiovascular events, and type 2 diabetes mellitus. Both stroke and all-cause mortality are both increased as OSA increases in severity.
Source: Dental Abstracts - Category: Dentistry Tags: Inquiry Source Type: research
CONCLUSIONS: The use of CPAP in patients with CAD and OSA might prevent subsequent cardiovascular events, which was only demonstrated in observational studies, but not in RCTs. The value of CPAP therapy as second prevention for CAD needs further investigation. PMID: 29636058 [PubMed - in process]
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Respir Res Source Type: research
The relationship between obstructive sleep apnea (OSA) and adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention (PCI) remains unclear. We performed a systematic review and meta-analysis to assess the impact of OSA on subsequent cardiovascular events after PCI. We searched the PubMed, EMBASE, and Cochrane library from their inceptions to August 5, 2017. We included cohort studies that described the association between OSA (based on apnea-hypopnea index) and cardiovascular outcomes after PCI with stenting. The primary endpoint was major adverse cardiovascular event (MACE), including all-...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Meta-Analysis of Observ Studies in Epidemiology Source Type: research
Conclusions: We recommend making a diagnosis of hypogonadism only in men with symptoms and signs consistent with testosterone (T) deficiency and unequivocally and consistently low serum T concentrations. We recommend measuring fasting morning total T concentrations using an accurate and reliable assay as the initial diagnostic test. We recommend confirming the diagnosis by repeating the measurement of morning fasting total T concentrations. In men whose total T is near the lower limit of normal or who have a condition that alters sex hormone-binding globulin, we recommend obtaining a free T concentration using either equil...
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Endocrinol Metab Source Type: research
ConclusionsThis study adds to growing evidence that cardiovascular risk from TRT may be less than once feared. The increased risk of sleep apnea in men using TRT is noteworthy. The study strengths include the large number of healthy and young men exposed to TRT. Limitations include the retrospective study design inability to account for granular details of TRT use such as dosage, specific forms of TRT and serum testosterone levels pre‐ and post‐TRT.This article is protected by copyright. All rights reserved.
Source: BJU International - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Introduction: The association of Obstructive Sleep Apnea Syndrom (OSAS) with cardiovascular diseases as coronary heart disease (CVD), hypertension, stroke, arrhythmias, heart failure and metabolic disease as diabetes II is well documented. Results of correlations with different parameters of OSAS as Apnea-/Hypopnea-Index (AHI), Oxygen-Desaturation-Index (ODI), minimal Oxygen saturation (SaO2  min), mean Oxygensaturation (mean SaO2) or time with oxygen saturation below 90% (SaO2
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: Sleep Breathing Disorders Source Type: research
Introduction: Obstructive sleep apnea is a common chronic medical condition strongly linked with obesity. Obstructive sleep apnea has been associated with cardiovascular morbidity such as arterial hypertension, stroke and heart failure, but the majority of these studies were done in sleep laboratory populations of predominantly male subjects. We hypothesize that obstructive sleep apnea will be associated with arterial hypertension in both genders in the general population.
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: Sleep Breathing Disorders Source Type: research
Conclusions:Hypoxia induced by nightly cessation of breathing increases patients' risk of coronary artery disease, heart failure, stroke, and other conditions. As with many maladies detrimental to vascular health, obstructive sleep apnea affects the eye and ocular adnexa. This paper summarizes the current evidence implicating OSA in these ocular maladies and highlights their proposed mechanisms. The authors describe ocular pathology which sleep specialists may encounter. We encourage more aggressive attention to ocular symptoms in patients with sleep apnea to prevent vision-threatening complications. Further research shoul...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Abstract Emerging research highlights the complex interrelationships between sleep-disordered breathing and cardiovascular disease, presenting clinical and research opportunities as well as challenges. Patients presenting to cardiology clinics have a high prevalence of obstructive and central sleep apnea associated with Cheyne-Stokes respiration. Multiple mechanisms have been identified by which sleep disturbances adversely affect cardiovascular structure and function. Epidemiological research indicates that obstructive sleep apnea is associated with increases in the incidence and progression of coronary heart dis...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
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