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Presentation and outcome of frequent and rare sarcoma histologic subtypes: A study of 10,262 patients with localized visceral/soft tissue sarcoma managed in reference centers

The objective of this study was to describe characteristics at diagnosis and outcomes of adults with soft tissue sarcoma. METHODSThe authors conducted a retrospective multicenter study of 12,262 patients who were treated between January 1980 and 31 December 2013 in French Sarcoma Group centers and enrolled in the “Conticabase.” Diagnoses were systematically reviewed by expert pathologists, and entities were classified according to the 2013 World Health Organization classification. Diagnostic characteristics, treatments, and outcomes are described for the entire cohort, for the subgroup of patients with translocation‐related sarcomas, and for 9 different histologic subtypes. RESULTSThe results stressed the magnitude of heterogeneity among adult sarcomas. For example, compared with other sarcomas, translocation‐related sarcomas (2143 tumors; 20.8%) were associated with a younger age at presentation (40.6 vs 60.0 years; P 
Source: Cancer - Category: Cancer & Oncology Authors: Tags: Original Article Source Type: research

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AbstractPurpose of ReviewThe purpose of this review is to inform readers of the most current management strategies for women with uterine sarcoma.Recent FindingsSurgery is the standard of care in the management of all soft-tissue sarcomas, including uterine sarcoma. However, there are malignancies that can be challenging to diagnose preoperatively and can mimic the appearance of benign uterine leiomyomas. Because of aggressive tumor biology and relative chemotherapy and radiotherapy resistance, efficacious therapies to achieve prolonged survival or cure in those with both early- and advanced-stage uterine sarcomas have bee...
Source: Current Obstetrics and Gynecology Reports - Category: OBGYN Source Type: research
In this study, we examined the antitumor effects and mechanism of action of trabectedin on human clear cell sarcoma cell lines. We showed that trabectedin decreased the cell proliferation of five clear cell sarcoma cell lines in a dose‐dependent manner in vitro and reduced tumor growth of two mouse xenograft models. Flow cytometry and immunoblot analyses in vitro and immunohistochemical analysis in vivo revealed that trabectedin‐induced G2/M cell cycle arrest and apoptosis. Furthermore, trabectedin increased the expression of melanocytic differentiation markers along with downregulation of ERK activity in vitro and the...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: Original Research Source Type: research
Conclusions Postoperative RT is used much more commonly than preoperative RT in localized STS; however, preoperative RT use has increased in recent years. Multiple demographic and clinicopathologic factors were predictive of preoperative RT use. Consistent with randomized phase 3 data, there was no difference in OS.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Abstract BackgroundNonretroperitoneal abdominal soft tissue sarcoma (NRA‐STS) is a rare disease with limited data supporting its management. Our study aimed to reveal the utilization patterns of adjuvant therapy and its potential survival benefits using the National Cancer Data Base. MaterialsThe analysis included patients with resected high‐grade NRA‐STS. Chi‐square analysis was used to evaluate distribution of patient and tumor‐related factors within treatment groups. The Kaplan–Meier and Cox proportional hazards model were utilized to evaluate overall survival according to treatment approach. Multivariat...
Source: Asia-Pacific Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions: Patients with high-grade STS treated with interdigitated neoadjuvant CT and radiation before surgical resection had excellent rates of local control, along with disease-free survival and overall survival similar to previously published reports. This combined-modality approach continues to have a role in the treatment of patients with high-grade STS.
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research
Authors: Fijuth J Abstract Paediatric malignancies are relatively rare, with an annual frequency of 13-14 in 100 000 children up to 15 years, and account for less than 1% of all cancer in developed countries. Paediatric tumours are generally managed with a multi-modality treatment programme that includes surgery, chemotherapy, and external beam radiation therapy (EBRT). Treatment strategies directed towards the reduction of late side effects have significantly increased interest in brachytherapy, in particular of soft tissue sarcoma and clear cell adenocarcinoma, as in these malignancies often only a limited target...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Conclusion: Our data support the use of NCT followed by limb-sparing surgery and adjuvant EBRT in ESTS for local failure reduction with a trend toward improved DFS.
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research
The management of locally advanced extremity soft tissue sarcoma of the limbs is challenging, particularly for recurrent tumors and those adjacent to neurovascular bundles and joints. Typically, the tumors are large, below the fascia, and high‐grade (T2b or stage III according to the American Joint Committee on Cancer) and thus require multimodal therapy. Treatment options must be tailored to patient and tumor characteristics. Isolated limb perfusion with recombinant human tumor necrosis factor α and melphalan (TNF‐ILP) adds a therapeutic option to radiation therapy (RT) and systemic chemotherapy. Although the pr...
Source: Cancer - Category: Cancer & Oncology Authors: Tags: Review Article Source Type: research
Desmoplastic small round cell tumor is a rare, aggressive tumor primarily affecting young males. It is considered a childhood cancer, and is characterized by a unique chromosomal translocation which leads to failure to suppress tumor growth. It is classified as a soft tissue sarcoma, sharing some features with other small round cell tumors such as Ewing's Sarcoma and primitive neuroectodermal tumor. Typical imaging findings include multiple heterogeneous, lobular abdominal masses, which can grow very large. Often there is a dominant mass with additional peritoneal, omental, retroperitoneal and retrovesical masses. Prognosi...
Source: Journal of Radiology Case Reports - Category: Radiology Source Type: research
Conclusion IORT in combination with oncologic resection of high-risk ESTS yields excellent rates of LC and limb salvage with acceptable morbidity.
Source: Journal of Radiation Oncology - Category: Cancer & Oncology Source Type: research
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