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Pain signal-jamming device may be an opioid alternative

Medical devices for chronic pain treatment are becoming small, smarter, and lasting longer, meaning they may soon be viable alternatives to addictive prescription opioid painkillers.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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AbstractPurpose of ReviewThe opioid crisis most likely is the most profound public health crisis our nation has faced. In 2015 alone, 52,000 people died of drug overdoses, with over 30,000 of those people dying from opioid drugs. A recent community forum led by the Cleveland Clinic contrasted this yearly death rate with the loss of 58,000 American lives in 4  years of the Vietnam War. The present review describes the origins of this opioid epidemic and provides context for our present circumstances.Recent FindingsAlarmingly, the overwhelming majority of opioid abusers begin their addiction with prescription medication...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
Abstract This is an editorial summarizing recent new developments in visceral analgesics. This promising field is important as a new approach to address abdominal pain with peripheral visceral analgesics is considered a key approach to addressing the current opioid crisis. Some of the novel compounds address peripheral pain mechanisms through modulation of opioid receptors through biased ligands, nociceptin/orphanin FQ opioid peptide (NOP) receptor or dual action on NOP and μ-opioid receptor, buprenorphine and morphiceptin analogs. Other compounds target non-opioid mechanisms including cannabinoid (CBR2), N-met...
Source: Am J Physiol Gastroi... - Category: Gastroenterology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
Chronic geriatric pain is a complex condition to assess and treat. Older age is associated with several highly prevalent comorbid pain conditions including both musculoskeletal and neurologic conditions.1 The impact of pain in older persons goes far beyond physiologic risks to include impaired cognitive function, depression, sleep disturbance, diminished socialization, increased healthcare use and costs, and impaired functional abilities.2 Despite the prevalence and potential impact, stoic attitudes of older adults in pain, myths about pain being a natural element of aging, and fears about potential addiction, can lead to ...
Source: Geriatric Nursing - Category: Nursing Authors: Source Type: research
I am a physician in recovery and just celebrated my fifth-year anniversary on October 11, 2017. While in active addiction, my drugs of choice were benzodiazepines and opioids that I washed down with top-shelf alcohol. Near the end of my usage, I was diverting scheduled drugs in order to feed my addiction. After an unsuccessful suicide attempt, I finally admitted myself for treatment. As part of the treatment process, I enrolled with our state’s physician help program (PHP). Because of my diversion, they were obligated to report me to the medical board who in turn suspended my license for six months. After that time p...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Psychiatry Source Type: blogs
25.3 million (11.2%) American adults suffer from daily chronic pain (Nahin, J Pain, 2015), with treatments often providing inadequate pain relief, adverse events, tolerance, dependence, and addiction. Natural products offer a safer alternative. Resveratrol was shown to be effective in mouse models of diabetic neuropathy (Sharma, Kulkarni and Chopra, Fundam Clin Pharmacol, 2007), chronic constriction injury (Tao, Ding et  al., Int Immunopharmacol, 2016), and incision-induced allodynia (Tillu, Melemedjian et al., Mol Pain, 2012).
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Opioids are an important component of chronic pain management for some patients; however, others may develop unrelenting tolerance, unmanageable side effects, opioid-induced hyperalgesia, opioid misuse, or other challenges that demand revision of care. Options for opioid management may then include: enhanced self-regulation, tightened prescribing structure, rotation or scheduling changes, tapering to lower doses (with or without rotation), discontinuation (with or without addition of naltrexone), or transition to opioid agonist therapy of addiction (OAT).
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
WASHINGTON (AP) — Companies selling some of the most lucrative prescription painkillers funneled millions of dollars to advocacy groups that in turn promoted the medications' use, according to a report released Monday by a U.S. senator. The investigation by Missouri's Sen. Claire McCaskill sheds light on the opioid industry's ability to shape public opinion and raises questions about its role in an overdose epidemic that has claimed hundreds of thousands of American lives. Representatives of some of the drugmakers named in the report said they did not set conditions on how the money was to be spent or force the group...
Source: JEMS: Journal of Emergency Medical Services News - Category: Emergency Medicine Authors: Tags: News Administration and Leadership Source Type: news
ConclusionsThe study highlights the attitudes of chronic pain patients in Ireland towards medicinal cannabis. It shows their desire to have medical cannabis legalised for chronic pain and that they view it as a reasonable pain management option.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
February 13, 2018 at 1pm ET The National Institute for Health Care Management (NIHCM) Foundation is hosting The Opioid Crisis: Understanding Pain and Preventing Opioid Misuse. “This webinar will get to the heart of the prevention question, exploring efforts across the health system to stop opioid abuse before it starts. Speakers will discuss: Efforts to standardize the use of opioids to treat chronic pain based on CDC guidelines, and the use of insurance data to identify non-standard treatment patterns for targeted outreach Partnerships to collect data and share best practices for reducing opioid use in the are...
Source: BHIC - Category: Databases & Libraries Authors: Tags: Substance Addiction and Misuse Webinars health systems opioid Source Type: blogs
Authors: Chen J, Liu XM, Zhang Y Abstract Different types of neuronal nicotinic acetylcholine receptors (nAChRs) are expected to occur in vivo, most structure-activity relationship studies have been carried out for just a few neuronal subtypes. The present review enlightens current aspects of venom modulators of nAChRs. Important electronic databases such as PubMed or Google scholar were explored for the collection of latest studies in the field. Clinical and basic research has shown that cholinergic receptors play a role in several disorders of the nervous system such as chronic pain, Alzheimers disease and addict...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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