Genetic alterations in sporadic triple negative breast cancer.

CONCLUSION: We show a strong association between TNBC and mutations in BRCA1/2 genes and the poor outcome of these patients. Moreover, we identified several other unknown mutations putatively associated with the poor prognosis of TNBC tumors. We also discovered novel mutations never before associated with breast cancer that could putatively account for the poor prognosis of the TNBC tumors.
PMID: 29202330 [PubMed - as supplied by publisher]

Source: Breast - December 1, 2017 Category: Cancer & Oncology Authors: Pop LA, Cojocneanu-Petric RM, Pileczki V, Morar-Bolba G, Irimie A, Lazar V, Lombardo C, Paradiso A, Berindan-Neagoe I Tags: Breast Source Type: research