Research finds new ways to fight the opioid crisis

(American College of Neuropsychopharmacology) In the US alone, more than 2 million people struggle with opioid use disorders. Opioids, often prescribed as pain medications, have now become the country's leading cause of drug overdose. But scientists are identifying ways to help combat the epidemic, which include getting people treatment faster, developing safer opioids, and helping patients choose appropriate treatment. A number of recent breakthroughs are being presented at the upcoming conference of the American College of Neuropsychopharmacology.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Publication date: December 2018Source: Trends in Pharmacological Sciences, Volume 39, Issue 12Author(s): Michael H. Baumann, Theresa A. Kopajtic, Bertha K. MadrasThe United States is experiencing an epidemic of opioid overdose deaths. Many of the recent fatalities are associated with illicitly manufactured fentanyl, which is being added to heroin and counterfeit pain pills. The crisis is further exacerbated by the emergence of an increasing number of novel synthetic opioids (NSOs), including various fentanyl analogs and non-fentanyl compounds that display potent agonist actions at the μ-opioid receptor. Importantly, mos...
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
In 2016, more than 42,200 deaths in the United States involved opioids.41 The rate of opioid-related deaths has risen steadily and drastically since 1999. Although public policy has focused on curbing these high rates, the epidemic remains a public health crisis. An important predictor of opioid overdose is the co-use of benzodiazepines.12,22,36 Benzodiazepines are frequently prescribed among patients with chronic pain due to their broad clinical applications, including treatment of anxiety, sleep disorders, and seizures.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
ConclusionTo date, no guidelines exist on prescribing opioids postoperatively. Opioids are overprescribed post ‐operatively with over half of patients using less than half of the opioids prescribed to them.
Source: Neurourology and Urodynamics - Category: Urology & Nephrology Authors: Tags: ORIGINAL CLINICAL ARTICLE Source Type: research
Abstract Drug overdose deaths involving opioids have surged in recent years and the economic cost of the opioid epidemic is estimated to be over $500 billion annually. In the midst of calls for declaring a national emergency, health policy decision makers are considering the best ways to allocate resources to curb the epidemic. On June 9, 2017, 116 invited health researchers, clinicians, policymakers, health system leaders, and other stakeholders met at the University of Pennsylvania to discuss approaches to address the gaps in evidence-based substance use disorder policy and practice, with an emphasis on the opio...
Source: Addiction Science and Clinical Practice - Category: Addiction Authors: Tags: Addict Sci Clin Pract Source Type: research
Ethimedix, a Swiss medical device company, has developed the SmartBottle, a drug administration device for analgesics. The device is a programmable “lockbox” which allows for the controlled administration of single doses of opioid painkil...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Geriatrics Medicine Pain Management Source Type: blogs
(CNN) — Despite the ongoing opioid crisis plaguing the nation, the US Food and Drug Administration on Friday approved a new opioid medication five to 10 times more powerful than fentanyl. Dsuvia, made by AcelRx Pharmaceuticals Inc., is a tablet in a single-dose, prefilled applicator to be administered under the tongue by health care providers to patients in settings such as hospitals, surgical centers and emergency rooms, according to the company. FDA Commissioner Dr. Scott Gottlieb was quick to defended the approval in a statement Friday: “The agency is taking new steps to more actively confront this crisis, ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Local TV opioids Source Type: news
CONCLUSIONS: The findings of this review offer clinical insight and reinforce the importance of psychosocial interventions in CNCP and opioid use disorders. However, little empirical data are available to guide practitioners in treating patients with CNCP who misuse opioid medications, and thus future research on integrated approaches, is needed. PMID: 30387858 [PubMed - in process]
Source: Journal of Opioid Management - Category: Addiction Tags: J Opioid Manag Source Type: research
CONCLUSIONS: This study identified clinical and demographic characteristics of previous ED patient visits who subsequently present to the ED with an opioid overdose. These characteristics will be vital toward an increased understanding of subjects who subsequently experience an opioid overdose. PMID: 30387856 [PubMed - in process]
Source: Journal of Opioid Management - Category: Addiction Tags: J Opioid Manag Source Type: research
Overdose is a continuing public health crisis. According to the Centers for Disease Control and Prevention, nearly 64,000 Americans died from drug overdose in 2016 – nearly 175 every day. (Hedegaard et al., 2017) Drug overdose deaths – the majority of which are caused by opioids, either alone or in combination with other substances – now kill more Americans than did HIV/AIDS at the peak of that epidemic. (Dowell et al., 2017)
Source: Drug and Alcohol Dependence - Category: Addiction Authors: Source Type: research
Publication date: April 2019Source: Current Opinion in Behavioral Sciences, Volume 26Author(s): Nicolas Massaly, Jose A MorónPain has a useful protective role; through avoidance learning, it helps to decrease the probability of engaging in tissue-damaging, or otherwise dangerous experiences. In our modern society, the experience of acute post-surgical pain and the development of chronic pain states represent an unnecessary negative outcome. This has become an important health issue as more than 30% of the US population reports experiencing “unnecessary” pain at any given time. Opioid therapies are often ...
Source: Current Opinion in Behavioral Sciences - Category: Psychiatry & Psychology Source Type: research
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