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Study examines brain activity and anxiety symptoms in youth with autism spectrum disorder

(Wiley) The error-related negativity (ERN) is a brain signal response to errors that is thought to reflect threat sensitivity and has been implicated in anxiety disorders in individuals without autism spectrum disorder (ASD).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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ConclusionFindings revealed ratings of anxiety in youth with and without autism spectrum disorder facing surgery varied by reporter and setting, highlighting the importance of using multiple reporters in research of youth with autism spectrum disorder in the perioperative period. Furthermore, while results showed group differences in premedication patterns and induction compliance, groups did not differ in level of negative behavior change after surgery. Future research can examine how individual differences in youth with autism impact anxiety in the perioperative setting and degree of behavior change postprocedure.
Source: Pediatric Anesthesia - Category: Anesthesiology Authors: Tags: RESEARCH REPORT Source Type: research
ABSTRACT Neurodevelopmental disorders such as autism spectrum disorders and schizophrenia have an expansive array of reported genetic and environmental contributing factors. However, none of these factors alone can account for a substantial proportion of cases of either disorder. Instead, many gene‐by‐environment interactions are responsible for neurodevelopmental disturbances that lead to these disorders. The current experiment used heterozygous knock‐out mice to examine a potential interaction between two factors commonly linked to neurodevelopmental disorders and cognitive deficit: imbalanced excitatory/inhibitory...
Source: Genes, Brain and Behavior - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
ens I Abstract Although there is increasing research interest in the parenting of children with ASD, at present, little is known about everyday strategies used to manage problem behaviour. We conducted a meta-synthesis to explore what strategies parents use to manage irritability, non-compliance, challenging behaviour and anxiety in their children with ASD. Approaches included: (1) accommodating the child; (2) modifying the environment; (3) providing structure, routine and occupation; (4) supervision and monitoring; (5) managing non-compliance with everyday tasks; (6) responding to problem behaviour; (7) managing ...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
CONCLUSIONS: Psychiatrically referred youth with ASD suffer from multiple highly impairing psychiatric disorders that require combination pharmacotherapy. These findings highlight the need for further research to guide clinical decision-making and treatment. PMID: 29188907 [PubMed - as supplied by publisher]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
This study provides descriptive data for a cohort of 155 autistic adults (mean age = 27.1 years, SD = 11.9) of average IQ on the short-form version of the Depression Anxiety Stress Scales and the Mini Social Phobia Inventory. Also included were 79 non-ASD participants (mean age = 26.2, SD = 10.2) who completed the mini-SPIN. A substantial percentage (39-46%) of autistic adults scored within the 'Moderate' to 'Extremely Severe' range on the DASS-21. The DASS-21 would be a valuable rapid screening device for these comorbid conditions in autistic adults. PMID: 29198...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
Anxiety is one of the most common problems people face today, and yet, it is often complicated with other co-existing conditions, such as obsessive compulsive disorder, autism, and depression. Comorbidity can make treatment challenging, even for clinicians who specialize in anxiety. In her new book, Tough-To-Treat Anxiety: Hidden Problems &Effective Solutions For Your Clients, licensed clinical psychologist Margaret Wehrenberg breaks down anxiety into its most common presentations, offering a host of treatment methods that work in the moment, and resist remission for years to come. “Unremitting anxiety may be one...
Source: Psych Central - Category: Psychiatry Authors: Tags: Anxiety Book Reviews Obsessive-Compulsive Disorder Treatment anxiety treatment difficult anxiety overwhelming anxiety tough to treat anxiety Source Type: news
The objective of this study is to evaluate the effectiveness of the ETAP program on the quality of life and anxio-depressive symptoms of parents of a child with ASD. To our knowledge, the ETAP program is the first TE program in France for parents of children with an ASD that has been evaluated. Our sample is composed of 40 participants, including 30 parents who participated in the ETAP program ("ETAP Group"), compared to ten controls who did not participate, but who are on a waiting list ("Control Group"). Each participant completed a Quality of Life Questionnaire (WhoQol-Brief) and an Anxiety-Depressiv...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
Discussion Findings highlighted the role that uncertainty plays in anxiety in autism, supporting existing theoretical accounts. Implications for clinical practice were discussed. These included ensuring that communication differences are minimised, and highlighting the importance of meaningfully including autistic people throughout the development and evaluation process of interventions for mental health.
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
Abstract Neuropsychiatric disorders in which reduced social interest is a common symptom, such as autism, depression, and anxiety, are frequently associated with genetic mutations affecting GABAergic transmission. Benzodiazepine treatment, acting via GABAA receptors, improves social interaction in male mouse models with autism‐like features. The protein diazepam binding inhibitor (DBI) can act as an endogenous benzodiazepine, but a role for DBI in social behavior has not been described. Here we investigated the role of DBI in the social interest and recognition behavior of mice. The responses of DBI wild‐type and knock...
Source: Genes, Brain and Behavior - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
(University of California - Riverside) Jan Blacher, a distinguished professor in the Graduate School of Education at the University of California, Riverside, found mothers of teenagers with autism spectrum disorder (ASD) or intellectual disability (ID) reported higher levels of stress and other negative psychological symptoms -- think depression or anxiety -- than mothers of teenagers with typical development (TD). Those levels climbed even higher when teenagers with ASD or ID also showed signs of clinical-level disruptive behavior disorders.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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