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Loss of CDKL5 disrupts respiratory function in mice

Publication date: Available online 5 December 2017 Source:Respiratory Physiology & Neurobiology Author(s): Kun-Ze Lee, Wenlin Liao Cyclin-dependent kinase-like 5 (CDKL5) is an X-linked gene encoding a serine-threonine kinase that is highly expressed in the central nervous system. Mutations in CDKL5 cause neurological and psychiatric symptoms, including early-onset seizures, motor dysfunction, autistic features and sleep breathing abnormalities in patients. It remains to be addressed whether loss of CDKL5 causes respiratory dysfunction in mice. Here, we examined the respiratory pattern of male Cdkl5 −/y mice at 1-3 months of age during resting breathing and respiratory challenge (i.e., hypoxia and hypercapnia) via whole body plethysmography. The results demonstrated that the resting respiratory frequency and tidal volume of Cdkl5 −/y mice was unaltered compared to that of WT mice at 1 month of age. However, these mutant mice exhibit transient reduction in tidal volume during respiratory challenge, even if the reduction was restored since 2 months of age. Notably, the sigh-breathing pattern was changed in Cdkl5 −/y mice, showing a transient reduction in sigh volume at 1–2 month of age and long-term attenuation of peak expiratory airflow from 1 to 3 month of age. Therefore, loss of CDKL5 causes breathing deficiency, supporting a CDKL5-mediated regulation of respiratory function in mice.
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research

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Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
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Source: Susan's Blog - Category: Child Development Authors: Tags: Uncategorized Source Type: blogs
In some people with autism, there can be what appears to be an acquisition of skills and then a loss of them. People have asked me over the years if Nat lost skills. Tough question. My feeling has always been that skills showed up and then became quieter while he was working on other skills. I never believed that they disappeared entirely. He has always developed skills and returned to them. His development has not been linear, however. It is more like a series of loops but always a growing chain of them. For example, at certain “age-appropriate” stages, he has rejected typical toys or activities. Lined up by d...
Source: Susan's Blog - Category: Child Development Authors: Tags: Uncategorized Source Type: blogs
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Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
Conditions:   Physical Activity;   Sleep Apnea;   Autism Spectrum Disorder Intervention:   Behavioral: Jogging program Sponsor:   The Hong Kong Polytechnic University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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