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Loss of CDKL5 disrupts respiratory function in mice

Publication date: Available online 5 December 2017 Source:Respiratory Physiology & Neurobiology Author(s): Kun-Ze Lee, Wenlin Liao Cyclin-dependent kinase-like 5 (CDKL5) is an X-linked gene encoding a serine-threonine kinase that is highly expressed in the central nervous system. Mutations in CDKL5 cause neurological and psychiatric symptoms, including early-onset seizures, motor dysfunction, autistic features and sleep breathing abnormalities in patients. It remains to be addressed whether loss of CDKL5 causes respiratory dysfunction in mice. Here, we examined the respiratory pattern of male Cdkl5 −/y mice at 1-3 months of age during resting breathing and respiratory challenge (i.e., hypoxia and hypercapnia) via whole body plethysmography. The results demonstrated that the resting respiratory frequency and tidal volume of Cdkl5 −/y mice was unaltered compared to that of WT mice at 1 month of age. However, these mutant mice exhibit transient reduction in tidal volume during respiratory challenge, even if the reduction was restored since 2 months of age. Notably, the sigh-breathing pattern was changed in Cdkl5 −/y mice, showing a transient reduction in sigh volume at 1–2 month of age and long-term attenuation of peak expiratory airflow from 1 to 3 month of age. Therefore, loss of CDKL5 causes breathing deficiency, supporting a CDKL5-mediated regulation of respiratory function in mice.
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research

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Source: Neuron - Category: Neuroscience Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Alzheimer's Bipolar Celebrities Children and Teens College Creativity Disorders Happiness Phobia Psychology Around the Net Research Sleep Women's Issues Alzheimer's disease Bipolar Disorder brain Creative Thinking Embarra Source Type: blogs
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Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
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Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report Current Issue ASD association autism autism spectrum disorder psychosis Source Type: research
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Source: The ASHA Leader Online - Category: Speech-Language Pathology Source Type: research
Children with neurodevelopmental disorders (NDD) are at high risk for sleep problems, especially insomnia. It is currently not known whether behavioural sleep interventions developed for typically developing (TD) children are effective for children with NDD, and if interventions need to be modified for each diagnostic group. The aim of this systematic review was to identify and evaluate commonalities, trends in outcomes, and the methodological quality of parent-delivered behavioural sleep interventions for children with NDD, specifically Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Cereb...
Source: Sleep Medicine Reviews - Category: Sleep Medicine Authors: Tags: Clinical Review Source Type: research
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Source: Basic and Clinical Pharmacology and Toxicology - Category: Drugs & Pharmacology Source Type: research
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Source: Molecular Autism - Category: Molecular Biology Source Type: research
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Source: Journal of Developmental and Physical Disabilities - Category: Disability Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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