An important lesson in assessing neurovascular involvement in proximal humeral fractures: the presence of neuropathic pain in a dysvascular limb
Proximal humerus fracture is a common upper limb fracture with an incidence of around 5%.12,13,20 It is often a result of a high-energy injury in the younger population; in the elderly, it is often due to a trivial fall.6,10 The proximity of the infraclavicular plexus and the brachial artery (the brachial bundle) to the fracture site can result in a variety of possible neurovascular presentations, making the injury uniquely challenging.22 Hence, clinicians should maintain a high index of suspicion for neurovascular compromise complicating even a simple proximal humerus fracture.
RHEUMATOID arthritis is a type of joint pain condition that affects about 400,000 people in the UK. What is the condition, and what are the signs to look out for? This Morning ’s Dr Chris reveals the symptoms of the autoimmune condition.
Conclusion: Although use of RA techniques in geriatric trauma patients with multiple rib fractures was associated with higher MED, opioid use decreased after RA initiation and Acute Pain Service consultation, and the risk of delirium was lower.
Pneumonia is a common cause of respiratory infection, accounting for more than 800,000 hospitalizations in the United States annually. Presenting symptoms of pneumonia are typically cough, pleuritic chest pain, fever, fatigue, and loss of appetite. Children and the elderly have different presenting features of pneumonia, which include headache, nausea, abdominal pain, and absence of one or more of the prototypical symptoms. Knowledge of local bacterial pathogens and their antibiotic susceptibility and resistance profiles is the key for effective pharmacologic selection and treatment of pneumonia.
Angela Tuffnell, 57, from Cheshire, spent years battling varicose veins hidden inside her pelvis, leaving her in pain so excruciating she could barely stand and would even pass out.
Publication date: Available online 13 August 2018Source: The LancetAuthor(s): Peter Kranke, Stephanie Weibel
This study is registered with the ISRCTN registry, number ISRCTN29654603.FindingsBetween May 13, 2014, and Sept 2, 2016, 201 women were randomly assigned to the remifentanil PCA group and 200 to the pethidine group. One participant in the pethidine group withdrew consent, leaving 199 for analyses. The proportions of epidural conversion were 19% (39 of 201) in the remifentanil PCA group and 41% (81 of 199) in the pethidine group (risk ratio 0·48, 95% CI 0·34–0·66; p
ConclusionThese results suggest that PSE has therapeutic effects in RA mice with CIA, showing the potential as anti-arthritis reagent.Graphical abstract
When we interpret animal behaviour as humanlike, we risk simply seeing ourselves – which demeans us and themAnd so, the killer whale known as J35 is back to her old self. She is no longer carrying the dead body of a calf she heldaloft in the water for more than two weeks. Her so-calledtour of grief has ended, to the relief of a global audience who had become wrapped up in this heart-wrenching animal drama. Great news, right? Sure. Yet I have a strange feeling in my stomach. It ’s a familiar one. The pedant in me is stirring, eager to get us to consider what we know about animals and what we don’t – ...
Publication date: Available online 13 August 2018Source: Neuroscience LettersAuthor(s): Andrew H. Cooper, Jennifer J. Brightwell, Naomi S. Hedden, Bradley K. TaylorAbstractThe left and right central nucleus of the amygdala (CeA) exert asymmetric pronociceptive functions. In the setting of a transient noxious stimulus or persistent inflammatory pain, neuronal activity increases in the right but not left CeA, regardless of side of injury. Much less is known regarding this lateralization with respect to the behavioral manifestations of persistent neuropathic pain. To address this question, we conducted spared nerve injury (SN...
In this study, we evaluate the potential pharmacological effects of PSAP on acute stress restriction (ARS)-induced depressive and anxiogenic-like behavior associated with hyperalgesia and mechanical allodynia in male adult Swiss mice (25–35 g). The ARS is an unavoidable stress situation that was applied for a period of 4 h using an individual rodent restraint. Ten min after ARS, the animals were treated with the PSAP (10 mg/kg, intragastrically [IG]) or imipramine (IMI, 10 mg/kg, IG) and after thirty min they were submitted to the behavioral observations in the forced swimming test (FST), sucrose preference t...