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Ranges of phenotypic flexibility in healthy subjects

ConclusionThe results of the metabolic PhenFlex test in conjunction with the health space reliably assessed health on an individual basis. This quantification can be used in the future for personalized health quantification and advice.
Source: Genes and Nutrition - Category: Nutrition Source Type: research

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Conclusions The pancreatic exocrine SP is a potential reservoir of adult stem/progenitor cells, consistent with previous evidence that such cells are duct-derived and express CD133.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research
Authors: Huang H, Shetty S, Bauer E, Lang K Abstract OBJECTIVE: To estimate the proportion of patients with moderate to severe chronic kidney disease (CKD) whose initial DPP4-i dosage was concordant with prescribing information (label) recommendations in the United States. METHODS: Adult patients with T2DM who initiated a DPP4-i (linagliptin, sitagliptin, saxagliptin) between Jan 1, 2011 and Jun 30, 2014 were identified using electronic medical records and administrative claims, with index date being the date of first observed DPP4-i treatment. Patients were required to have CKD Stage 3b, 4 or 5 (eGFR value
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Conclusions: In diabetic patients with NAFLD, light or moderate lifetime alcohol consumption was not significantly associated with liver fibrosis. The impact of lifetime alcohol intake on fibrosis progression and diabetic comorbidities, in particular obstructive sleep apnea and hypertriglyceridemia, requires further investigation. PMID: 29226116 [PubMed - in process]
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
Conditions:   Type2 Diabetes;   Depression Interventions:   Behavioral: Program ACTIVE Exercise;   Behavioral: Program ACTIVE CBT;   Behavioral: Program ACTIVE;   Behavioral: Usual Care - No intervention Sponsors:   Indiana University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   West Virginia University;   Ohio University;   University of Michigan Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   NAFLD;   Diabetes Mellitus, Type 2;   Hypertriglyceridemia;   Fatty Liver, Nonalcoholic Interventions:   Drug: ISIS 703802;   Drug: Placebo Sponsors:   Ionis Pharmaceuticals, Inc.;   Akcea Therapeutics Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: CREDENCE will provide definitive evidence about the effects of canagliflozin on renal (and cardiovascular) outcomes in patients with type 2 diabetes and established kidney disease.Trial Registration: EudraCT number: 2013-004494-28; ClinicalTrials.gov identifier: NCT02065791.
Source: American Journal of Nephrology - Category: Neurology Source Type: research
What is it about flour, i.e., the starch, bran, and germ of seeds of grass plants, such as modern Triticum species of wheat, that makes them extravagantly fattening? The weight gain effect of modern wheat is so powerful that I call it the perfect obesogen, a food that is perfectly crafted to cause obesity. As a society, we have conducted a massive and inadvertent experiment. Based on the flawed logic that emerged from “white flour is bad, whole grains are good” epidemiological observations (or what I would label “white flour is bad, whole grains are less bad” observations), the American diet, thanks...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle blood sugar edema gluten grains Inflammation insulin opiates Weight Loss Source Type: blogs
This study enrolled 7,804 male workers free of diabetes in 1986. CRF was measured using a cycle ergometer, and maximal oxygen uptake was estimated. During 1986-2009, participants were followed for development of type 2 diabetes, which was diagnosed using fasting blood tests, self-administered questionnaires, or oral glucose tolerance tests after urinary tests from annual health checkups. Hazard ratios for the incidence of type 2 diabetes were estimated using Cox proportional hazards models. RESULTS: During the follow-up period, 1,047 men developed type 2 diabetes. In analyses by follow-up periods (1986-1993, 1994-2001,...
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
Authors: Bazargan-Hejazi S, Arroyo JS, Hsia S, Brojeni NR, Pan D Abstract Objective: To investigate: 1) the racial/ethnic disparities in meeting the recommended physical activity as measured by subjective vs objective measures in a national sample of individuals with type 2 diabetes mellitus; and 2) the racial/ethnic differences with respect to the magnitude of the discrepancy between self-reported and objectively measured moderate-to-vigorous intensity aerobic physical activity (MVPA). Methods: We used data from the National Health and Nutrition Examination Survey (NHANES) 2003-06 to calculate and compare the ...
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
(Natural News) A comprehensive study reveals evidence of the beneficial properties of substituting whole grains to refined grain diets – such as losing weight and reducing inflammation – particularly among overweight people who are most at risk of developing cardiovascular diseases and type-2 diabetes. Researchers from the National Food Institute worked together with the Department...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
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