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Androgen receptor overexpression in prostate cancer in type 2 diabetes

Conclusions We report elevated androgen receptor signaling and activity presumably due to altered insulin/IGF-1 receptors and decreased levels of protective estrogen receptor ligands in prostate cancer in men with diabetes. Our results reveal new insights why these patients have a worse prognosis. These findings provide the basis for future clinical trials to investigate treatment response in patients with prostate cancer and diabetes.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research

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Authors: Saad F Abstract Since the early 1990s, it has been recognized that testosterone (T) levels are lower in men with type 2 diabetes mellitus (T2DM) compared with nondiabetic men (controls). Hypogonadism has been reported in approximately 50% of men with T2DM with robust correlations with measures of obesity, such as waist circumference and body mass index (BMI). In longitudinal studies, hypogonadism has been identified as a predictor of incident T2DM. Experimental withdrawal of T led to acute decreased insulin sensitivity, which can be reversed by normalization of T concentrations. Androgen deprivation therap...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
ConclusionTestosterone therapy may moderately improve sexual desire and erectile function in men with Type 2 diabetes; however, available data are limited, and the long‐term risks of testosterone therapy are not known in this specific patient group. We conclude that testosterone therapy is a potential treatment for men with Type 2 diabetes non‐responsive to phosphodiesterase‐5 inhibitors. Testosterone therapy could be considered for men with Type 2 diabetes when potential risks and benefits of therapy are carefully considered and other therapeutic options are unsuitable.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - Category: Endocrinology Authors: Tags: Systematic Review or Meta ‐analysis Source Type: research
This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates breast cancer growth by inhibiting NF-κB activation. Endocrinology. 2017 Oct 13;: Authors: Iwaya C, Nomiyama T, Komatsu S, Kawanami T, Tsutsumi Y, Hamaguchi Y, Horikawa T, Yoshinaga Y, Yamashita S, Tanaka T, Terawaki Y, Tanabe M, Nabeshima K, Iwasaki A, Yanase T Abstract Incretin therapies have received significant attention because of their tissue-protective effects, which extend beyond those associated with glycemic control. Cancer is a primary cause of death in patients with diabetes mellitus. We previously reported anti-prosta...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research
Being diagnosed with breast cancer can make a person feel powerless, but there are some things women can do to potentially improve how they feel throughout the process. Here are some strategies recommended by experts—and others that are still being explored—which may help improve the effectiveness and symptoms of treatment. Physical activity “Exercise is one of the best things women can do for themselves,” says Dr. Ann Partridge, director of the Program for Young Women with Breast Cancer at Dana-Farber Cancer Institute. “It doesn’t mean marathons or hot yoga, but walking three to five ti...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized Breast Cancer breast cancer symptoms breast cancer treatment Exercise Meditation Nutrition TIME Health Breast Cancer yoga yoga cancer patients Source Type: news
A 50-year-old African American man with a history of  hypertension, type 2 diabetes, stage III chronic kidney disease, and prostate cancer was admitted for an elective robot-assisted laparoscopic prostatectomy with pelvic lymph node resection. On admission, the patient was normotensive with an unremarkable examination. His home atorvastatin, amlodip ine, and lisinopril were continued during hospitalization. Admission labs included a creatinine of 1.8 and blood urea nitrogen (BUN) 23 mg/dl, with normal electrolytes.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
Abstract BACKGROUND: Metformin (MF), a diabetic drug, has antineoplastic activity as adjuvant therapy for breast cancer and prostate cancer. MF is thought to work via inhibition of mammalian target of rapamycin and activation of p53 and liver kinase B1 via adenosine 5'-monophosphate-activated protein kinase. We investigated survival, recurrences and metastasis in patients with type 2 diabetes mellitus (DM2) along with colorectal cancer (CC) or lung cancer (LC) taking MF using the electronic medical record in Memphis Veterans Affairs Medical Center (colon, n = 202; lung, n = 180). MATERIALS AND METHODS: Patien...
Source: The American Journal of the Medical Sciences - Category: General Medicine Authors: Tags: Am J Med Sci Source Type: research
Nature Medicine 23, 1215 (2017). doi:10.1038/nm.4393 Authors: Paul J Emmerson, Feng Wang, Yong Du, Qian Liu, Richard T Pickard, Malgorzata D Gonciarz, Tamer Coskun, Matthew J Hamang, Dana K Sindelar, Kimberly K Ballman, Lisa A Foltz, Avinash Muppidi, Jorge Alsina-Fernandez, Gavin C Barnard, Jason X Tang, Xilin Liu, Xudong Mao, Robert Siegel, John H Sloan, Pamela J Mitchell, Bei B Zhang, Ruth E Gimeno, Bei Shan &Xinle Wu Growth/differentiation factor 15 (GDF15), also known as MIC-1, is a distant member of the transforming growth factor-β (TGF-β) superfamily and has been implicated in various biological fu...
Source: Nature Medicine - Category: General Medicine Authors: Tags: Letter Source Type: research
Abstract To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 meta-analyses of observational studies, coffee was associated with a probable decreased risk of breast, colorectal, colon, endometrial, and prostate cancers; cardiovascular disease and mortality; Parkinson's disease; and type-2 diabetes. Of the 14 unique outcomes examined in the 20 selected meta-analyses of observational stu...
Source: Annual Review of Nutrition - Category: Nutrition Authors: Tags: Annu Rev Nutr Source Type: research
Metformin is a biguanide oral hypoglycaemic agent commonly used for the treatment of type 2 diabetes mellitus. In addition to its anti-diabetic effect, metformin has also been associated with a reduced risk of...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Source Type: research
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