Outcomes of radiation therapy for advanced T3/T4 nonmelanoma cutaneous squamous cell and basal cell carcinoma

Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Research Letter Source Type: research

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Conclusion: This study showed that it is possible to distinguish between the different nonmelanoma skin cancers by using OCT, but further prospective studies have to be conducted to validate the sensitivity and specificity of the criteria.Skin Pharmacol Physiol 2018;31:238 –245
Source: Skin Pharmacology and Physiology - Category: Dermatology Source Type: research
Abstract Cutaneous squamous cell carcinoma (cSCC) is an increasing public health problem. It is a primary malignant skin tumor with Malpighian differentiation and together with basal cell carcinoma is classified among nonmelanoma skin cancers (NMSCs). cSCC usually occurs on photoexposed areas, such as the head, the neck, and the extremities, and its incidence increases with age. Invasive forms of this skin tumor tend to be more aggressive showing a higher metastatic potential, usually regarding regional lymph nodes. Treatment options for invasive cSCCs include both surgical and nonsurgical options. The therapeutic...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusions: With appropriate patient selection and choosing as lowest dose per fraction as possible, HDR brachytherapy with customized surface molds yields good oncological and cosmetic results for the treatment of localized skin BCC and SCC. PMID: 29789760 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
AbstractPurpose of ReviewThe aims of this report are to review literature supporting the use of Mohs micrographic surgery for treatment of non-melanoma skin cancer and to address indications and potential limitations of this form of therapy for non-melanoma skin cancer.Recent FindingsThe first randomized controlled trial comparing standard excision to Mohs micrographic surgery for treatment of facial basal cell carcinoma has recently been published, demonstrating a lower recurrence rate after Mohs surgery compared to standard excision after a 5-year and 10-year follow-up period, supporting its use in the treatment of high-...
Source: Current Otorhinolaryngology Reports - Category: ENT & OMF Source Type: research
AbstractNon-melanoma skin cancer (NMSC) is the most prevalent type of cancer among Caucasian populations worldwide. The purpose of this work was to measure quality of life (QOL) of the patients with diagnosis of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) who were referred to our cancer clinic. During 1  year, 95 patients were selected and asked to complete Dermatology Life Quality Index (DLQI) questionnaires. Ninety-five patients with NMSC (74 men and 21 women) with mean age of 64.6 ± 12.5 participated in this cross-sectional study. From 95 patients, 75 had BCC, 15 had SCC, and 5...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
Higher nevus count is associated with increased risk of melanoma in adults. However, few studies have examined the association between nevus count and non-melanoma skin cancers. We sought to examine the association between nevus count and the risk of melanoma and non-melanoma skin cancers in three large prospective cohorts: the Nurses Health study (NHS), Nurses Health Study 2 (NHS2), and the Health Professionals Follow-up Study (HPFS). We followed up 176,317 women (74,241 from the NHS, 1986-2012; 102,076 from the NHS2, 1989-2013) and 32,383 men (from the HPFS, 1986-2012), among whom there were 1,704 incident cases of melan...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Light hair color is an established risk factor for melanoma. Whether hair color is associated with risk of keratinocyte carcinoma, also known as non-melanoma skin cancer, has not been thoroughly studied. We prospectively examined the association between natural hair color at adulthood and risk of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) based on a total 205,307 participants from the Nurses Health Study (NHS, n=78,879), NHS II (n=89,516), and Health Professionals Follow-up Study (HPFS, n=36,912).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Itch and pain have previously been shown to be associated with non-melanoma skin cancers with itch linked with more superficial basal cell carcinoma (BCC) lesions and pain associated with histologic features that involve the deeper dermal processes in squamous cell carcinoma (SCC) lesions. The mediators underlying itch and pain of non-melanoma skin cancers are poorly understood. Biopsies of skin cancer lesions (n=50) underwent immunohistochemistry for PAR2, tryptase, substance P and b-tubulin for nerve fibers.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
Elevated expression of osteopontin (OPN), a matricellular, adhesive glycoprotein, is associated with numerous cancer types. We have reported that ultraviolet B (UVB)-induced OPN is a critical driver for cutaneous squamous cell carcinoma (cSCC) development in the photocarcinogenesis model. In human skin cancer, UVB exposure is the major risk factor on the development of nonmelanoma skin cancer. Immunohistochemical analyses indicated that OPN protein is markedly increased in actinic keratoses, cSCC, and differentiated basal cell carcinoma (BCC), but not in solid basal cell epitheliomas when compared with no sun-exposed skin.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Growth Factors, Cell Adhesion and Matrix Biology Source Type: research
Light hair color is an established risk factor for melanoma. Whether hair color is associated with risk of keratinocyte carcinoma, also known as non-melanoma skin cancer, has not been thoroughly studied. We prospectively examined the association between natural hair color at adulthood and risk of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) based on a total 205,307 participants from the Nurses Health Study (NHS, n=78,879), NHS II (n=89,516), and Health Professionals Follow-up Study (HPFS, n=36,912).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
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