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Comparison of the association of mammographic density and clinical factors with ductal carcinoma in situ versus invasive ductal breast cancer in Korean women

In spite of the increasing incidence of in situ breast cancer, the information about the risk factors of in situ breast cancer (DCIS) is scarce as compared to the information available for invasive ductal brea...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research

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Publication date: Available online 6 December 2017 Source:Journal of Structural Biology Author(s): Jennie A.M.R. Kunitake, Siyoung Choi, Kayla X. Nguyen, Meredith M. Lee, Frank He, Daniel Sudilovsky, Patrick G. Morris, Maxine S. Jochelson, Clifford A. Hudis, David A. Muller, Peter Fratzl, Claudia Fischbach, Admir Masic, Lara A. Estroff Microcalcifications (MCs) are routinely used to detect breast cancer in mammography. Little is known, however, about their materials properties and associated organic matrix, or their correlation to breast cancer prognosis. We combine histopathology, Raman microscopy, and electron microscop...
Source: Journal of Structural Biology - Category: Biology Source Type: research
Abstract Mammography screening has increased the detection of early pre‐invasive breast cancers, termed ductal carcinoma in situ (DCIS), increasing the urgency of identifying molecular regulators of invasion as prognostic markers to predict local relapse. Using the MMTV‐PyMT breast cancer model and pharmacological protease inhibitors, we reveal that cysteine cathepsins have important roles in early‐stage tumorigenesis. To characterize the cell‐specific roles of cathepsins in early invasion, we developed a DCIS‐like model, incorporating an immortalized myoepithelial cell line (N1ME) that restrained tumor cell inva...
Source: The Journal of Pathology - Category: Pathology Authors: Tags: Original Paper Source Type: research
ConclusionsScreening mammography detects mostly high-grade DCIS and low- or intermediate-grade invasive cancers. The grade distribution as well as the CDR in the years after the introduction of FFDM remained stable compared to the era of SFM screening. By diagnosing and treating high-grade DCIS, which otherwise may develop into high-grade invasive carcinoma, our findings provide new evidence for the beneficial value of screening mammography programmes.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Conclusions Both CEDM and MRI detected additional cancers not seen on conventional mammography, primarily invasive cancers. Our pilot data suggest that CEDM could be valuable as a supplemental imaging exam for women at increased risk for breast cancer who do not meet the criteria for MRI or for whom access to MRI is limited. Validation in larger multi institutional trials is warranted.
Source: European Journal of Radiology - Category: Radiology Source Type: research
Conclusions In three national surveys, it was found that CAD use at US digital screening mammography facilities was stable from 2008 to 2016. This persistent utilization is relevant to the debate on the value of targeting ductal carcinoma in situ in screening.
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
Margin-free excision of small solid breast carcinomas using the Intact Breast Lesion Excision System(®): is it feasible? Breast Cancer. 2017 Sep 16;: Authors: Papapanagiotou IK, Koulocheri D, Kalles V, Liakou P, Michalopoulos NV, Al-Harethee W, Georgiou G, Matiatou M, Nonni A, Pazaiti A, Theodoropoulos GE, Menenakos E, Zografos GC Abstract BACKGROUND: The Breast Lesion Excision System(®) (BLES(®)) is a stereotactic vacuum-assisted breast biopsy device that utilizes radiofrequency in order to excise non-palpable mammographic lesions for pathologic diagnosis. The purpose of this study was to...
Source: Breast Cancer - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research
This study compared the characteristics of screening-detected and symptom-detected T1a,bN0 breast cancer, and investigated the impact of accompanying DCIS on detection and prognosis.Patients and Methods: Data were collected from a single hospital between 2000 and 2009. Of 5,690 primary breast cancers patients, 438 met the criteria for T1a,bN0M0. Logistic regression models were used to identify prognostic indicators and their association with the detection method. Survival analyses were performed to estimate distant relapse-free survival (DRFS) and breast cancer-specific survival (BCSS).Results: Tumors in 79 and 359 patient...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Conclusion: For lesions initially described as BI-RADS 3 and 4a with a histological diagnosis of fibroadenoma after biopsy, short-term follow-up can be avoided.Breast Care 2017;12:238-242
Source: Breast Care - Category: Cancer & Oncology Source Type: research
Conclusions: Although further work is required to confirm our results and to clarify potential mechanisms, our findings suggest that exposure to residential outdoor light at night may contribute to invasive breast cancer risk. https://doi.org/10.1289/EHP935 Received: 08 August 2016 Revised: 17 March 2017 Accepted: 20 March 2017 Published: 17 August 2017 Address correspondence to P. James, 401 Park Dr., 3rd Floor West, Boston, MA 02215 USA. Telephone: (617) 525-2567; Email: pjames@hsph.harvard.edu Supplemental Material is available online (https://doi.org/10.1289/EHP935). The authors declare they have no actual or pot...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
A 44-year-old woman was found to have 2 groups of calcifications within the left breast on routine screening mammogram: one at 2 o'clock measuring 28  mm and a second at 3 o'clock measuring 40 mm. Follow-up diagnostic mammogram confirmed multiple groups of pleomorphic calcifications spanning>7  cm in the upper outer quadrant. Stereotactic core needle biopsy noted invasive carcinoma, predominantly lobular type, grade 2, estrogen receptor positive (Allred 8), progesterone receptor positive (Allred 8), HER2 negative (0) at the 2 o'clock site; and ductal carcinoma in situ without invasion a t 3 o'clock.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
More News: Breast Cancer | Breast Carcinoma | Cancer | Cancer & Oncology | Carcinoma | Carcinoma in Situ | DCIS (Ductal Carcinoma in Situ) | Ductal Carcinoma | Mammography | Women