Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer

Targeting the type 1 insulin-like growth factor receptor (IGF1R) in breast cancer remains an ongoing clinical challenge. Oncogenic IGF1R-signaling occurs via activation of PI3K/AKT/MAPK downstream mediators wh...

Source: BMC Cancer - December 5, 2017 Category: Cancer & Oncology Authors: Aleksandra M. Ochnik and Robert C. Baxter Tags: Research article Source Type: research