Neurologic and Functional Morbidity in Critically Ill Children With Bronchiolitis*

Objectives: Neurologic and functional morbidity occurs in ~30% of PICU survivors, and young children may be at particular risk. Bronchiolitis is a common indication for PICU admission among children less than 2 years old. Two single-center studies suggest that greater than 10–25% of critical bronchiolitis survivors have neurologic and functional morbidity but those estimates are 20 years old. We aimed to estimate the burden of neurologic and functional morbidity among more recent bronchiolitis patients using two large, multicenter databases. Design: Analysis of the Pediatric Health Information System and the Virtual Pediatric databases. Setting: Forty-eight U.S. children’s hospitals (Pediatric Health Information System) and 40 international (mostly United States) children’s hospitals (Virtual Pediatric Systems). Patients: Previously healthy PICU patients less than 2 years old admitted with bronchiolitis between 2009 and 2015 who survived and did not require extracorporeal membrane oxygenation or cardiopulmonary resuscitation. Interventions: None. Neurologic and functional morbidity was defined as a Pediatric Overall Performance Category greater than 1 at PICU discharge (Virtual Pediatric Systems subjects), or a subsequent hospital encounter involving developmental delay, feeding tubes, MRI of the brain, neurologist evaluation, or rehabilitation services (Pediatric Health Information System subjects). Measurements and Main Results: Among 3,751 Virtual Pe...
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Feature Articles Source Type: research